| # | Title | Journal | Year | Citations |
|---|
| 1 | First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial | Lancet, The | 2021 | 1,237 |
| 2 | Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study | BMJ, The | 2021 | 136 |
| 3 | Bacteria induce expression of apoptosis in human spermatozoa | Apoptosis: an International Journal on Programmed Cell Death | 2005 | 104 |
| 4 | Copanlisib plus rituximab versus placebo plus rituximab in patients with relapsed indolent non-Hodgkin lymphoma (CHRONOS-3): a double-blind, randomised, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2021 | 83 |
| 5 | Effect of Escherichia coli and its soluble factors on mitochondrial membrane potential, phosphatidylserine translocation, viability, and motility of human spermatozoa | Fertility and Sterility | 2010 | 79 |
| 6 | The effect of dulaglutide on stroke: an exploratory analysis of the REWIND trial | Lancet Diabetes and Endocrinology,the | 2020 | 77 |
| 7 | Canine sperm vitrification with sucrose: effect on sperm function | Andrologia | 2011 | 70 |
| 8 | Hantavirus Pulmonary Syndrome Due to Andes Virus in Temuco, Chile | Chest | 2001 | 63 |
| 9 | Efficacy, pharmacokinetics, and safety of the biosimilar CT-P10 in comparison with rituximab in patients with previously untreated low-tumour-burden follicular lymphoma: a randomised, double-blind, parallel-group, phase 3 trial | Lancet Haematology,the | 2018 | 53 |
| 10 | Effects of basal insulin glargine and omega-3 fatty acid on cognitive decline and probable cognitive impairment in people with dysglycaemia: a substudy of the ORIGIN trial | Lancet Diabetes and Endocrinology,the | 2014 | 52 |
| 11 | Prognostic validation of a non-laboratory and a laboratory based cardiovascular disease risk score in multiple regions of the world | Heart | 2018 | 49 |
| 12 | LBA41 LEAP-005: Phase II study of lenvatinib (len) plus pembrolizumab (pembro) in patients (pts) with previously treated advanced solid tumours | Annals of Oncology | 2020 | 44 |
| 13 | LEAP-005: A phase II multicohort study of lenvatinib plus pembrolizumab in patients with previously treated selected solid tumors—Results from the colorectal cancer cohort. | Journal of Clinical Oncology | 2021 | 43 |
| 14 | Influence of reactive oxygen species produced by activated leukocytes at the level of apoptosis in mature human spermatozoa | Fertility and Sterility | 2005 | 40 |
| 15 | Vitrified sperm banks: the new aseptic technique for human spermatozoa allows cryopreservation at −86 °C | Andrologia | 2012 | 38 |
| 16 | Lenvatinib plus pembrolizumab for patients with previously treated biliary tract cancers in the multicohort phase II LEAP-005 study. | Journal of Clinical Oncology | 2021 | 34 |
| 17 | Ability of Escherichia coli to produce hemolysis leads to a greater pathogenic effect on human sperm | Fertility and Sterility | 2015 | 29 |
| 18 | Use of the fluorescent dye tetramethylrhodamine methyl ester perchlorate for mitochondrial membrane potential assessment in human spermatozoa | Andrologia | 2017 | 29 |
| 19 | The environmental profile of a community’s health: a cross-sectional study on tobacco marketing in 16 countries | Bulletin of the World Health Organization | 2015 | 29 |
| 20 | Incidence of insulin-dependent diabetes mellitus in the IX region of Chile: ethnic differences | Diabetes Research and Clinical Practice | 1996 | 27 |
| 21 | Oral L-glutamine pretreatment attenuates skeletal muscle atrophy induced by 24-h fasting in mice | Journal of Nutritional Biochemistry | 2019 | 26 |
| 22 | Polymorphisms in Genes Involved in the Leptin-Melanocortin Pathway are Associated with Obesity-Related Cardiometabolic Alterations in a Southern Chilean Population | Molecular Diagnosis and Therapy | 2018 | 20 |
| 23 | Participation of the sperm proteasome during in vitro fertilisation and the acrosome reaction in cattle | Andrologia | 2011 | 19 |
| 24 | Nitrosative stress by peroxynitrite impairs ATP production in human spermatozoa | Andrologia | 2017 | 19 |
| 25 | Nitrosative stress in human spermatozoa causes cell death characterized by induction of mitochondrial permeability transition-driven necrosis | Asian Journal of Andrology | 2018 | 18 |
| 26 | Similar cardiovascular outcomes in patients with diabetes and established or high risk for coronary vascular disease treated with dulaglutide with and without baseline metformin | European Heart Journal | 2021 | 17 |
| 27 | Recommendations for SARS-CoV-2/COVID-19 testing: a scoping review of current guidance | BMJ Open | 2021 | 17 |
| 28 | Effective universal health coverage and improved 1-year survival after acute myocardial infarction: the Chilean experience | Health Policy and Planning | 2016 | 16 |
| 29 | Effect of mitochondrial calcium uniporter blocking on human spermatozoa | Andrologia | 2015 | 14 |
| 30 | LED‐based red light photostimulation improves short‐term response of cooled boar semen exposed to thermal stress at 37°C | Andrologia | 2019 | 14 |
| 31 | Experimental Model of HindLimb Suspension-Induced Skeletal Muscle Atrophy in Rodents | Methods in Molecular Biology | 2019 | 14 |
| 32 | Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects | International Journal of Obesity | 2020 | 14 |
| 33 | Ectopic pituitary adenoma of the TSH-secreting sphenoidal sinus with excellent response to somatostatin analogs. Theory of the embryogenesis and literature review from a clinical case | Steroids | 2020 | 14 |
| 34 | Lenvatinib plus pembrolizumab for patients with previously treated biliary tract cancers in the multicohort phase 2 LEAP-005 study. | Journal of Clinical Oncology | 2021 | 14 |
| 35 | Ten-Year Surveillance of Pneumococcal Infections in Temuco, Chile: Implications for Vaccination Strategies | Vaccine Journal | 2007 | 13 |
| 36 | Contribution of ethnic group and socioeconomic status to degree of disability in rheumatoid arthritis in Chilean patients | Rheumatology International | 2015 | 11 |
| 37 | Derivation of a measure of systolic blood pressure mutability: a novel information theory-based metric from ambulatory blood pressure tests | Journal of the American Society of Hypertension | 2016 | 11 |
| 38 | Prevalence of Infection and Antibiotic Susceptibility of Helicobacter pylori: An Evaluation in Public and Private Health Systems of Southern Chile | Pathogens | 2019 | 10 |
| 39 | Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis | Experimental Gerontology | 2020 | 10 |
| 40 | The Current State of MicroRNAs as Restenosis Biomarkers | Frontiers in Genetics | 2019 | 10 |
| 41 | Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension | Brazilian Journal of Medical and Biological Research | 2019 | 10 |
| 42 | Multiparameter Flow Cytometry Assay for Analysis of Nitrosative Stress Status in Human Spermatozoa | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2020 | 9 |
| 43 | Andes Hantavirus as possible cause of disease in travellers to South America | Travel Medicine and Infectious Disease | 2007 | 8 |
| 44 | Balanced Diet-Fed Fat-1 Transgenic Mice Exhibit Lower Hindlimb Suspension-Induced Soleus Muscle Atrophy | Nutrients | 2017 | 8 |
| 45 | Influence of adenovirus 36 seropositivity on the expression of adipogenic microRNAs in obese subjects | International Journal of Obesity | 2020 | 8 |
| 46 | Antioxidant effects of penicillamine against in vitro‐induced oxidative stress in human spermatozoa | Andrologia | 2020 | 8 |
| 47 | LEAP-005: A phase II multicohort study of lenvatinib plus pembrolizumab in patients with previously treated selected solid tumors—Results from the gastric cancer cohort. | Journal of Clinical Oncology | 2021 | 8 |
| 48 | LEAP-005: A phase 2 multicohort study of lenvatinib plus pembrolizumab in patients with previously treated selected solid tumors—Results from the colorectal cancer cohort. | Journal of Clinical Oncology | 2021 | 8 |
| 49 | Autophagy is activated in human spermatozoa subjected to oxidative stress and its inhibition impairs sperm quality and promotes cell death | Human Reproduction | 2022 | 8 |
| 50 | Impaired brown adipose tissue is differentially modulated in insulin-resistant obese wistar and type 2 diabetic Goto-Kakizaki rats | Biomedicine and Pharmacotherapy | 2021 | 7 |
