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Top Articles

#TitleJournalYearCitations
1PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTORJournal of Clinical Investigation2007321
2Regulation of Autophagy by mTOR Signaling PathwayAdvances in Experimental Medicine and Biology2019211
3Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1Nature Cell Biology2011128
4Human acupuncture points mapped in rats are associated with excitable muscle/skin–nerve complexes with enriched nerve endingsBrain Research2004115
5Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failureGut2021108
6Identification and characterization of selenoprotein K: An antioxidant in cardiomyocytesFEBS Letters2006103
7S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage responseEMBO Journal2010103
8Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathwayNature Communications202087
9NMDA receptor activation induces mitochondrial dysfunction, oxidative stress and apoptosis in cultured neonatal rat cardiomyocytesPhysiological Research200784
10Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocksNature Cell Biology201979
11PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling CascadeJournal of Biological Chemistry201473
12GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failureAmerican Journal of Physiology - Heart and Circulatory Physiology200566
13Effects of ghrelin and synthetic GH secretagogues on the cardiovascular systemTrends in Endocrinology and Metabolism200663
14Pneumoconiosis: current status and future prospectsChinese Medical Journal202155
15Phosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) ActivationJournal of Biological Chemistry201154
16Application of a 3D Bioprinted Hepatocellular Carcinoma Cell Model in Antitumor Drug ResearchFrontiers in Oncology202052
17Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the ratPeptides201051
18Phosphoglyceric acid mutase-1 contributes to oncogenic mTOR-mediated tumor growth and confers non-small cell lung cancer patients with poor prognosisCell Death and Differentiation201851
19Clock-controlled mir-142-3p can target its activator, Bmal1BMC Molecular Biology201248
20SLC7A11/xCT Prevents Cardiac Hypertrophy by Inhibiting FerroptosisCardiovascular Drugs and Therapy202247
21MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1Autophagy201341
22mTOR/miR-145-regulated exosomal GOLM1 promotes hepatocellular carcinoma through augmented GSK-3β/MMPsJournal of Genetics and Genomics201941
23A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosaceaEMBO Molecular Medicine202141
24Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasionOncotarget201540
25Multi-omics study of silicosis reveals the potential therapeutic targets PGD2 and TXA2Theranostics202140
26Antiproliferative effects of melatonin on the growth of rat pituitary prolactin-secreting tumor cells in vitroJournal of Pineal Research200739
27Memory-related changes of nitric oxide synthase activity and nitrite level in rat brainNeuroReport199738
28Brain-expressed X-linked 2 Is Pivotal for Hyperactive Mechanistic Target of Rapamycin (mTOR)-mediated TumorigenesisJournal of Biological Chemistry201537
29The acute toxic effects of silver nanoparticles on myocardial transmembrane potential, INa and IK1 channels and heart rhythm in miceNanotoxicology201737
30mTOR promotes pituitary tumor development through activation of PTTG1Oncogene201736
31Efficacy of combined inhibition of mTOR and ERK/MAPK pathways in treating a tuberous sclerosis complex cell modelJournal of Genetics and Genomics200934
32Spinal cord injury triggers sensitization of wide dynamic range dorsal horn neurons in segments rostral to the injuryBrain Research200533
33Degeneration and energy shortage in the suprachiasmatic nucleus underlies the circadian rhythm disturbance in ApoE−/− mice: implications for Alzheimer’s diseaseScientific Reports201632
34CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoterMolecular and Cellular Biochemistry200831
35A novel role of microRNA 17-5p in the modulation of circadian rhythmScientific Reports201631
36<p>The acute toxic effects of platinum nanoparticles on ion channels, transmembrane potentials of cardiomyocytes in vitro and heart rhythm in vivo in mice</p>International Journal of Nanomedicine201928
37Early demyelination of primary A-fibers induces a rapid-onset of neuropathic pain in ratNeuroscience201227
38A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastomaOncotarget201524
39ON THE INVERSE CHANGE BETWEEN THE CONCENTRATION OF GLUCOSE AND CHLORIDE IN THE BLOODAmerican Journal of Physiology192623
40Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signalingJournal of Ethnopharmacology201621
41Analysis of genetic and clinical characteristics of a Chinese Kallmann syndrome cohort with ANOS1 mutationsEuropean Journal of Endocrinology201721
42Inhibitory effects of melatonin on the growth of pituitary prolactin-secreting tumor in ratsJournal of Pineal Research200620
43Activation of AMPA receptor promotes TNF-α release via the ROS-cSrc-NFκB signaling cascade in RAW264.7 macrophagesBiochemical and Biophysical Research Communications201519
44Deficient TSC1/TSC2-complex suppression of SOX9-osteopontin-AKT signalling cascade constrains tumour growth in tuberous sclerosis complexHuman Molecular Genetics201719
45The three branches of the unfolded protein response exhibit differential significance in breast cancer growth and stemnessExperimental Cell Research201819
46p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein responseCell Death and Disease202119
47Comparative Transcriptome Analyses Reveal a Transcriptional Landscape of Human Silicosis Lungs and Provide Potential Strategies for Silicosis TreatmentFrontiers in Genetics202119
48Oxidative status in the macula densa modulates tubuloglomerular feedback responsiveness in Angiotensin II‐induced hypertensionActa Physiologica201518
49Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathwaysOncology Reports201618
50Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestineWorld Journal of Gastroenterology200118