| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 3 | Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins | Nature Medicine | 2004 | 1,200 |
| 4 | Georgenia ruanii sp. nov., a novel actinobacterium isolated from forest soil in Yunnan (China), and emended description of the genus Georgenia | International Journal of Systematic and Evolutionary Microbiology | 2007 | 770 |
| 5 | Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression | Metabolism: Clinical and Experimental | 2010 | 356 |
| 6 | Advanced glycation in d-galactose induced mouse aging model | Mechanisms of Ageing and Development | 1999 | 350 |
| 7 | Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro | Antiviral Research | 2009 | 326 |
| 8 | High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses | Journal of Virology | 2019 | 244 |
| 9 | Ciprofloxacin derivatives and their antibacterial activities | European Journal of Medicinal Chemistry | 2018 | 233 |
| 10 | Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression | Metabolism: Clinical and Experimental | 2009 | 224 |
| 11 | CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape | Cell Reports | 2016 | 215 |
| 12 | Transforming berberine into its intestine-absorbable form by the gut microbiota | Scientific Reports | 2015 | 190 |
| 13 | Antioxidant and Anti-Inflammatory Activities of Berberine in the Treatment of Diabetes Mellitus | Evidence-based Complementary and Alternative Medicine | 2014 | 182 |
| 14 | Bile acids initiate cholestatic liver injury by triggering a hepatocyte-specific inflammatory response | JCI Insight | 2017 | 181 |
| 15 | 4-Quinolone hybrids and their antibacterial activities | European Journal of Medicinal Chemistry | 2017 | 169 |
| 16 | Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications | Nature Communications | 2021 | 168 |
| 17 | In silico ADME and Toxicity Prediction of Ceftazidime and Its Impurities | Frontiers in Pharmacology | 2019 | 163 |
| 18 | A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel | Nature Communications | 2018 | 159 |
| 19 | Isolation of two highly potent and non-toxic inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase from Salvia miltiorrhiza | Antiviral Research | 2002 | 157 |
| 20 | CDKN1C (p57KIP2) Is a Direct Target of EZH2 and Suppressed by Multiple Epigenetic Mechanisms in Breast Cancer Cells | PLoS ONE | 2009 | 155 |
| 21 | Combination of simvastatin with berberine improves the lipid-lowering efficacy | Metabolism: Clinical and Experimental | 2008 | 144 |
| 22 | MicroRNAs 185, 96, and 223 Repress Selective High-Density Lipoprotein Cholesterol Uptake through Posttranscriptional Inhibition | Molecular and Cellular Biology | 2013 | 144 |
| 23 | Alkaloids from the Root of Isatis indigotica | Journal of Natural Products | 2012 | 136 |
| 24 | A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity. | Journal of Antibiotics | 1988 | 134 |
| 25 | TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription | Nature Communications | 2019 | 130 |
| 26 | A new macromolecular antitumor antibiotic, C-1027. III. Antitumor activity. | Journal of Antibiotics | 1989 | 116 |
| 27 | TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations | Nature Communications | 2015 | 116 |
| 28 | Diversity and structure of soil bacterial communities in the Fildes Region (maritime Antarctica) as revealed by 454 pyrosequencing | Frontiers in Microbiology | 2015 | 115 |
| 29 | Soil pH is a Key Determinant of Soil Fungal Community Composition in the Ny-Ålesund Region, Svalbard (High Arctic) | Frontiers in Microbiology | 2016 | 115 |
| 30 | Synthesis and in vitro antimycobacterial activity of 8-OCH3 ciprofloxacin methylene and ethylene isatin derivatives | European Journal of Medicinal Chemistry | 2011 | 109 |
| 31 | Tacrolimus-loaded ethosomes: Physicochemical characterization and in vivo evaluation | European Journal of Pharmaceutics and Biopharmaceutics | 2012 | 109 |
| 32 | SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells | Autophagy | 2017 | 109 |
| 33 | ROS-responsive nanoparticles based on amphiphilic hyperbranched polyphosphoester for drug delivery: Light-triggered size-reducing and enhanced tumor penetration | Biomaterials | 2019 | 107 |
| 34 | TRIB3 Interacts With β-Catenin and TCF4 to Increase Stem Cell Features of Colorectal Cancer Stem Cells and Tumorigenesis | Gastroenterology | 2019 | 104 |
| 35 | Advances and challenges in the treatment of esophageal cancer | Acta Pharmaceutica Sinica B | 2021 | 101 |
| 36 | SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation | PLoS Genetics | 2015 | 101 |
| 37 | Uralsaponins M–Y, Antiviral Triterpenoid Saponins from the Roots of Glycyrrhiza uralensis | Journal of Natural Products | 2014 | 98 |
| 38 | Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway | Phytotherapy Research | 2016 | 98 |
| 39 | Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats | Journal of Functional Foods | 2018 | 98 |
| 40 | Butyrate protects against high‐fat diet‐induced atherosclerosis via up‐regulating ABCA1 expression in apolipoprotein E‐deficiency mice | British Journal of Pharmacology | 2020 | 96 |
| 41 | Massilia dura sp. nov., Massilia albidiflava sp. nov., Massilia plicata sp. nov. and Massilia lutea sp. nov., isolated from soils in China | International Journal of Systematic and Evolutionary Microbiology | 2006 | 95 |
| 42 | A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties. | Journal of Antibiotics | 1988 | 94 |
| 43 | Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5 | Acta Pharmaceutica Sinica B | 2020 | 94 |
| 44 | Antiviral Matrine-Type Alkaloids from the Rhizomes of Sophora tonkinensis | Journal of Natural Products | 2015 | 93 |
| 45 | Learning from berberine: Treating chronic diseases through multiple targets | Science China Life Sciences | 2015 | 93 |
| 46 | Allosalinactinospora lopnorensis gen. nov., sp. nov., a new member of the family Nocardiopsaceae isolated from soil | International Journal of Systematic and Evolutionary Microbiology | 2015 | 93 |
| 47 | Protocatechuic aldehyde inhibits hepatitis B virus replication both in vitro and in vivo | Antiviral Research | 2007 | 92 |
| 48 | Protective Role of Salidroside against Aging in A Mouse Model Induced by D-galactose | Biomedical and Environmental Sciences | 2010 | 91 |
| 49 | Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure−Activity Relationships, and Cholesterol-Lowering Efficacy | Journal of Medicinal Chemistry | 2009 | 89 |
| 50 | Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance | Antiviral Research | 2011 | 89 |
