| # | Title | Journal | Year | Citations |
|---|
| 1 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 2 | Partitioning heritability by functional annotation using genome-wide association summary statistics | Nature Genetics | 2015 | 2,045 |
| 3 | Evidence for osteocyte regulation of bone homeostasis through RANKL expression | Nature Medicine | 2011 | 1,593 |
| 4 | Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis | Nature Medicine | 2014 | 930 |
| 5 | 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups | Annals of the Rheumatic Diseases | 2017 | 754 |
| 6 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 652 |
| 7 | Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1 | Cell Host and Microbe | 2012 | 578 |
| 8 | Osteoprotection by semaphorin 3A | Nature | 2012 | 501 |
| 9 | Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci | Nature Genetics | 2010 | 476 |
| 10 | Design and Experimental Application of a Novel Non-Degenerate Universal Primer Set that Amplifies Prokaryotic 16S rRNA Genes with a Low Possibility to Amplify Eukaryotic rRNA Genes | DNA Research | 2014 | 432 |
| 11 | Suppression of bone formation by osteoclastic expression of semaphorin 4D | Nature Medicine | 2011 | 426 |
| 12 | Microstructures and mechanical properties of Co–29Cr–6Mo alloy fabricated by selective laser melting process for dental applications | Journal of the Mechanical Behavior of Biomedical Materials | 2013 | 381 |
| 13 | Coupling of bone resorption and formation by RANKL reverse signalling | Nature | 2018 | 376 |
| 14 | IκBζ regulates TH17 development by cooperating with ROR nuclear receptors | Nature | 2010 | 361 |
| 15 | Bone Morphogenetic Proteins | Cold Spring Harbor Perspectives in Biology | 2016 | 356 |
| 16 | The Role of Autophagy in the Heart | Annual Review of Physiology | 2018 | 344 |
| 17 | Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects | Journal of Allergy and Clinical Immunology | 2018 | 344 |
| 18 | Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer | Nature Communications | 2017 | 306 |
| 19 | New insights into osteoclastogenic signaling mechanisms | Trends in Endocrinology and Metabolism | 2012 | 275 |
| 20 | IL-17-producing γδ T cells enhance bone regeneration | Nature Communications | 2016 | 271 |
| 21 | Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis | Nature Microbiology | 2019 | 270 |
| 22 | Oral hypofunction in the older population: Position paper of the Japanese Society of Gerodontology in 2016 | Gerodontology | 2018 | 264 |
| 23 | Mechanical properties of composite resin blocks for CAD/CAM | Dental Materials Journal | 2014 | 249 |
| 24 | Meta-analysis of Bonding Effectiveness to Zirconia Ceramics | Journal of Dental Research | 2014 | 244 |
| 25 | RANKL biology: bone metabolism, the immune system, and beyond | Inflammation and Regeneration | 2020 | 241 |
| 26 | Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment | Talanta | 2011 | 232 |
| 27 | Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial | Lancet Oncology, The | 2013 | 227 |
| 28 | A Role for Noncoding Variation in Schizophrenia | Cell Reports | 2014 | 225 |
| 29 | High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry | Nature Genetics | 2016 | 219 |
| 30 | Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4 | Immunity | 2013 | 215 |
| 31 | Host defense against oral microbiota by bone-damaging T cells | Nature Communications | 2018 | 215 |
| 32 | TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP | Oncogene | 2012 | 199 |
| 33 | Multiple-to-Multiple Relationships between MicroRNAs and Target Genes in Gastric Cancer | PLoS ONE | 2013 | 199 |
| 34 | Characterisation of dental pulp stem cells: A new horizon for tissue regeneration? | Archives of Oral Biology | 2012 | 197 |
| 35 | Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index | Human Molecular Genetics | 2014 | 192 |
| 36 | Rapid generation of mouse models with defined point mutations by the CRISPR/Cas9 system | Scientific Reports | 2014 | 191 |
| 37 | Ipragliflozin Improves Hepatic Steatosis in Obese Mice and Liver Dysfunction in Type 2 Diabetic Patients Irrespective of Body Weight Reduction | PLoS ONE | 2016 | 191 |
| 38 | Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension | Cell Reports | 2013 | 188 |
| 39 | Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 184 |
| 40 | Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes | American Journal of Human Genetics | 2014 | 182 |
| 41 | RANKL expressed on synovial fibroblasts is primarily responsible for bone erosions during joint inflammation | Annals of the Rheumatic Diseases | 2016 | 177 |
| 42 | Aicardi-Goutières Syndrome Is Caused by IFIH1 Mutations | American Journal of Human Genetics | 2014 | 175 |
| 43 | The 2009 prospective multi-center epidemiologic survey of uveitis in Japan | Japanese Journal of Ophthalmology | 2012 | 173 |
| 44 | Directional dominance on stature and cognition in diverse human populations | Nature | 2015 | 173 |
| 45 | Adipose tissue inflammation and ectopic lipid accumulation [Review] | Endocrine Journal | 2012 | 166 |
| 46 | Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering | Biomaterials | 2012 | 161 |
| 47 | Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study | Arthritis Research and Therapy | 2014 | 159 |
| 48 | MicroRNA-126 Inhibits SOX2 Expression and Contributes to Gastric Carcinogenesis | PLoS ONE | 2011 | 157 |
| 49 | Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis | Nature Communications | 2014 | 156 |
| 50 | Hyper‐CVAD plus ponatinib versus hyper‐CVAD plus dasatinib as frontline therapy for patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia: A propensity score analysis | Cancer | 2016 | 156 |
