| # | Title | Journal | Year | Citations |
|---|
| 1 | The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration | PLoS Medicine | 2009 | 13,772 |
| 2 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration | BMJ: British Medical Journal | 2009 | 13,452 |
| 3 | ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 8,654 |
| 4 | The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration | Journal of Clinical Epidemiology | 2009 | 8,425 |
| 5 | Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT Statement | PLoS Medicine | 2010 | 801 |
| 6 | Satellite Cells and Skeletal Muscle Regeneration | PLoS Medicine | 2015 | 489 |
| 7 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 8 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 9 | Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT Statement | Journal of Evidence-Based Medicine | 2010 | 335 |
| 10 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 11 | Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults* | Critical Care Medicine | 2015 | 268 |
| 12 | VEGF Gene Therapy Fails to Improve Perfusion of Ischemic Myocardium in Patients With Advanced Coronary Disease: Results of the NORTHERN Trial | Molecular Therapy | 2009 | 232 |
| 13 | Olanzapine in the Treatment of Low Body Weight and Obsessive Thinking in Women With Anorexia Nervosa: A Randomized, Double-Blind, Placebo-Controlled Trial | American Journal of Psychiatry | 2008 | 225 |
| 14 | Clinical review: Canadian National Advisory Committee on Blood and Blood Products - Massive Transfusion Consensus Conference 2011: report of the panel | Critical Care | 2011 | 131 |
| 15 | Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA): Extending the CONSORT Statement | Journal of Alternative and Complementary Medicine | 2010 | 111 |
| 16 | Wearable-Sensor-based Detection and Prediction of Freezing of Gait in Parkinson’s Disease: A Review | Sensors | 2019 | 110 |
| 17 | Alpha‐synuclein in the appendiceal mucosa of neurologically intact subjects | Movement Disorders | 2014 | 107 |
| 18 | Competing risk bias was common in Kaplan–Meier risk estimates published in prominent medical journals | Journal of Clinical Epidemiology | 2016 | 97 |
| 19 | Improving the reporting of randomised trials: the CONSORT Statement and beyond | Statistics in Medicine | 2012 | 96 |
| 20 | Muscle stem cells at a glance | Journal of Cell Science | 2014 | 95 |
| 21 | How to reduce unnecessary duplication: use PROSPERO | BJOG: an International Journal of Obstetrics and Gynaecology | 2014 | 93 |
| 22 | Association of caesarean delivery for first birth with placenta praevia and placental abruption in second pregnancy | BJOG: an International Journal of Obstetrics and Gynaecology | 2007 | 87 |
| 23 | PHF6 Interacts with the Nucleosome Remodeling and Deacetylation (NuRD) Complex | Journal of Proteome Research | 2012 | 87 |
| 24 | Safety, effectiveness, and cost effectiveness of long acting versus intermediate acting insulin for patients with type 1 diabetes: systematic review and network meta-analysis | BMJ, The | 2014 | 84 |
| 25 | The Immunomodulatory and Therapeutic Effects of Mesenchymal Stromal Cells for Acute Lung Injury and Sepsis | Journal of Cellular Physiology | 2015 | 81 |
| 26 | The Influence of Living Near Roadways on Spirometry and Exhaled Nitric Oxide in Elementary Schoolchildren | Environmental Health Perspectives | 2008 | 78 |
| 27 | Adequacy of prenatal care and neonatal mortality in infants born to mothers with and without antenatal high-risk conditions | Australian and New Zealand Journal of Obstetrics and Gynaecology | 2007 | 75 |
| 28 | Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A | Nature Communications | 2014 | 72 |
| 29 | Introduction to PRISMA 2020 and implications for research synthesis methodologists | Research Synthesis Methods | 2022 | 71 |
| 30 | Light Gradient Boosting Machine for General Sentiment Classification on Short Texts: A Comparative Evaluation | IEEE Access | 2020 | 69 |
| 31 | Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders | Science | 2022 | 67 |
| 32 | Core Domain Set Selection According to OMERACT Filter 2.1: The OMERACT Methodology | Journal of Rheumatology | 2019 | 65 |
| 33 | Four Proposals to Help Improve the Medical Research Literature | PLoS Medicine | 2015 | 60 |
| 34 | Systematic review of microRNA biomarkers in acute coronary syndrome and stable coronary artery disease | Cardiovascular Research | 2020 | 60 |
| 35 | Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 54 |
| 36 | Mass Production of Systematic Reviews and Meta‐analyses: An Exercise in Mega‐silliness? | Milbank Quarterly | 2016 | 54 |
| 37 | Rates of emergency department visits attributable to alcohol use in Ontario from 2003 to 2016: a retrospective population-level study | Cmaj | 2019 | 54 |
| 38 | Factor V Leiden mutation in women with early recurrent pregnancy loss: a meta-analysis and systematic review of the causal association | Archives of Gynecology and Obstetrics | 2015 | 50 |
| 39 | Quality of Reports on Randomized Controlled Trials Conducted in Japan: Evaluation of Adherence to the CONSORT Statement | Internal Medicine | 2009 | 49 |
| 40 | Exploring the frontiers of research co-production: the Integrated Knowledge Translation Research Network concept papers | Health Research Policy and Systems | 2019 | 49 |
| 41 | Neonatal mortality and morbidity in vertex–vertex second twins according to mode of delivery and birth weight | Journal of Perinatology | 2006 | 47 |
| 42 | Increasing public awareness about hepatitis C: development and validation of the brief hepatitis C knowledge scale | Scandinavian Journal of Caring Sciences | 2009 | 44 |
| 43 | Considerations and guidance in designing equity-relevant clinical trials | International Journal for Equity in Health | 2017 | 44 |
| 44 | The yield of CT pulmonary angiograms to exclude acute pulmonary embolism | Emergency Radiology | 2014 | 42 |
| 45 | Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice | International Journal of Obesity | 2015 | 42 |
| 46 | A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection | Pharmacoepidemiology and Drug Safety | 2018 | 37 |
| 47 | Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption | Critical Care Medicine | 2015 | 36 |
| 48 | Patients’ experience of shoulder disorders: a systematic review of qualitative studies for the OMERACT Shoulder Core Domain Set | Rheumatology | 2019 | 36 |
| 49 | Exclusion criteria and adverse events in perioperative trials of tranexamic acid: a systematic review and meta‐analysis | Transfusion | 2019 | 36 |
| 50 | The aging anesthesiologist: a narrative review and suggested strategies | Canadian Journal of Anaesthesia | 2014 | 35 |
