| # | Title | Journal | Year | Citations |
|---|
| 1 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 2 | Knowledge translation of research findings | Implementation Science | 2012 | 1,586 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 4 | AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews | Journal of Clinical Epidemiology | 2009 | 1,427 |
| 5 | Effects of Quality Improvement Strategies for Type 2 Diabetes on Glycemic Control | JAMA - Journal of the American Medical Association | 2006 | 583 |
| 6 | Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019 | Chest | 2020 | 531 |
| 7 | Oral rivaroxaban versus standard therapy for the treatment of symptomatic venous thromboembolism: a pooled analysis of the EINSTEIN-DVT and PE randomized studies | Thrombosis Journal | 2013 | 471 |
| 8 | The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2015 | 431 |
| 9 | The association between continuity of care and outcomes: a systematic and critical review | Journal of Evaluation in Clinical Practice | 2010 | 427 |
| 10 | STrengthening the REporting of Genetic Association Studies (STREGA)— An Extension of the STROBE Statement | PLoS Medicine | 2009 | 411 |
| 11 | Granulocyte Inflammatory Markers and Airway Infection during Acute Exacerbation of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2001 | 401 |
| 12 | Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2016 | 400 |
| 13 | SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice | PLoS ONE | 2008 | 397 |
| 14 | A systematic review of the use of theory in the design of guideline dissemination and implementation strategies and interpretation of the results of rigorous evaluations | Implementation Science | 2010 | 392 |
| 15 | Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy | Cancer Research | 2015 | 375 |
| 16 | Antithrombotic Therapy for VTE Disease | Chest | 2021 | 357 |
| 17 | Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC): a cluster randomised controlled trial | Lancet, The | 2011 | 323 |
| 18 | American Society of Hematology 2021 guidelines on the use of anticoagulation for thromboprophylaxis in patients with COVID-19 | Blood Advances | 2021 | 310 |
| 19 | SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons | Cell Metabolism | 2008 | 304 |
| 20 | Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant | JAMA Internal Medicine | 2019 | 283 |
| 21 | Growing Literature, Stagnant Science? Systematic Review, Meta-Regression and Cumulative Analysis of Audit and Feedback Interventions in Health Care | Journal of General Internal Medicine | 2014 | 272 |
| 22 | Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults | Canadian Journal of Cardiology | 2017 | 269 |
| 23 | Mycophenolate Mofetil Dose Reduction and the Risk of Acute Rejection after Renal Transplantation | Journal of the American Society of Nephrology: JASN | 2003 | 264 |
| 24 | Effect of discharge summary availability during post-discharge visits on hospital readmission | Journal of General Internal Medicine | 2002 | 262 |
| 25 | Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada: Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases | American Journal of Gastroenterology | 2017 | 241 |
| 26 | The 2014 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2014 | 221 |
| 27 | STrengthening the REporting of Genetic Association Studies (STREGA)—an extension of the STROBE statement | Genetic Epidemiology | 2009 | 211 |
| 28 | Pulmonary embolism | Nature Reviews Disease Primers | 2018 | 208 |
| 29 | Permeability barrier dysfunction in transgenic mice overexpressing claudin 6 | Development (Cambridge) | 2002 | 203 |
| 30 | Computerised clinical decision support systems and absolute improvements in care: meta-analysis of controlled clinical trials | BMJ, The | 2020 | 188 |
| 31 | Poor Prognosis in Warfarin-Associated Intracranial Hemorrhage Despite Anticoagulation Reversal | Stroke | 2012 | 186 |
| 32 | Human Endothelial Colony-Forming Cells Protect against Acute Kidney Injury | American Journal of Pathology | 2015 | 186 |
| 33 | Cardiac Complications in Patients with Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis of Observational Studies | PLoS Medicine | 2011 | 184 |
| 34 | Administrative database research has unique characteristics that can risk biased results | Journal of Clinical Epidemiology | 2012 | 178 |
| 35 | Transfer of microRNA-486-5p from human endothelial colony forming cell–derived exosomes reduces ischemic kidney injury | Kidney International | 2016 | 177 |
| 36 | Angiotensin-(1–7) inhibits angiotensin II-stimulated phosphorylation of MAP kinases in proximal tubular cells | Kidney International | 2006 | 171 |
| 37 | Roland-Morris Disability Questionnaire and Oswestry Disability Index: Which Has Better Measurement Properties for Measuring Physical Functioning in Nonspecific Low Back Pain? Systematic Review and Meta-Analysis | Physical Therapy | 2016 | 170 |
| 38 | A pilot study of central venous catheter survival in cancer patients using low‐molecular‐weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study) | Journal of Thrombosis and Haemostasis | 2007 | 169 |
| 39 | Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement | Human Genetics | 2009 | 167 |
| 40 | The 2013 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension | Canadian Journal of Cardiology | 2013 | 163 |
| 41 | Integrated strategies for the diagnosis of venous thromboembolism | Journal of Thrombosis and Haemostasis | 2007 | 162 |
| 42 | Cardiovascular Complications and Short-term Mortality Risk in Community-Acquired Pneumonia | Clinical Infectious Diseases | 2017 | 162 |
| 43 | Mapping 123 million neonatal, infant and child deaths between 2000 and 2017 | Nature | 2019 | 161 |
| 44 | The Canadian Celiac Health Survey | Digestive Diseases and Sciences | 2007 | 159 |
| 45 | Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use | Blood | 2016 | 156 |
| 46 | Diagnosis and treatment of deep-vein thrombosis | Cmaj | 2006 | 155 |
| 47 | Clinical Impact of Bleeding in Cancer-Associated Venous Thromboembolism: Results from the Hokusai VTE Cancer Study | Thrombosis and Haemostasis | 2018 | 154 |
| 48 | Acute myeloid leukaemia disrupts endogenous myelo-erythropoiesis by compromising the adipocyte bone marrow niche | Nature Cell Biology | 2017 | 150 |
| 49 | Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis | Cmaj | 2008 | 145 |
| 50 | The Efficacy and Safety of Heparin in Patients With Sepsis | Critical Care Medicine | 2015 | 144 |
