| # | Title | Journal | Year | Citations |
|---|
| 1 | An atlas of genetic influences on human blood metabolites | Nature Genetics | 2014 | 1,084 |
| 2 | Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture | Nature | 2015 | 483 |
| 3 | Mechanisms of Mammalian Iron Homeostasis | Biochemistry | 2012 | 465 |
| 4 | Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis | Gastroenterology | 2001 | 429 |
| 5 | Regulation of iron transport and the role of transferrin | Biochimica Et Biophysica Acta - General Subjects | 2012 | 383 |
| 6 | Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children | Canadian Journal of Cardiology | 2020 | 324 |
| 7 | Standardization of the Modified Rodnan Skin Score for Use in Clinical Trials of Systemic Sclerosis | Journal of Scleroderma and Related Disorders | 2017 | 321 |
| 8 | Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study | BMJ, The | 2013 | 307 |
| 9 | Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant | JAMA Internal Medicine | 2019 | 283 |
| 10 | Genetics of osteoporosis from genome-wide association studies: advances and challenges | Nature Reviews Genetics | 2012 | 269 |
| 11 | The IRP/IRE system in vivo: insights from mouse models | Frontiers in Pharmacology | 2014 | 254 |
| 12 | Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis | Autoimmunity Reviews | 2020 | 231 |
| 13 | The Interaction between HIV-1 Gag and APOBEC3G | Journal of Biological Chemistry | 2004 | 224 |
| 14 | Resting Energy Expenditure is Sensitive to Small Dose Changes in Patients on Chronic Thyroid Hormone Replacement1 | Journal of Clinical Endocrinology and Metabolism | 1997 | 203 |
| 15 | Regulation of the uncoupling protein gene expression | European Journal of Endocrinology | 1997 | 198 |
| 16 | Functional and Exercise Limitations After a First Episode of Pulmonary Embolism | Chest | 2017 | 192 |
| 17 | Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas | Clinical Cancer Research | 2016 | 186 |
| 18 | Comparison of the mineral content of tap water and bottled waters | Journal of General Internal Medicine | 2001 | 177 |
| 19 | Canadian clinical practice guidelines for acute and chronic rhinosinusitis | Allergy, Asthma and Clinical Immunology | 2011 | 153 |
| 20 | Inhaled Corticosteroids and the Prevention of Readmission to Hospital for Asthma | American Journal of Respiratory and Critical Care Medicine | 1998 | 145 |
| 21 | How I treat postthrombotic syndrome | Blood | 2009 | 138 |
| 22 | 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates | Osteoporosis International | 2011 | 138 |
| 23 | Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study | BMJ: British Medical Journal | 2018 | 138 |
| 24 | Coordinate regulation of triacylglycerol synthesis and glucose transport by acylation-stimulating protein | Metabolism: Clinical and Experimental | 1993 | 136 |
| 25 | N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department | Journal of the American College of Cardiology | 2018 | 136 |
| 26 | APOBEC3G Inhibits DNA Strand Transfer during HIV-1 Reverse Transcription | Journal of Biological Chemistry | 2007 | 135 |
| 27 | Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication | Journal of Virology | 1994 | 134 |
| 28 | The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases | Genes and Immunity | 2007 | 129 |
| 29 | Prediction of Poor Outcome After Transcatheter Aortic Valve Replacement | Journal of the American College of Cardiology | 2016 | 128 |
| 30 | Effect of Atherosclerosis on Endothelium-Dependent Inhibition of Platelet Activation in Humans | Circulation | 1998 | 122 |
| 31 | Lactose Intolerance, Dairy Avoidance, and Treatment Options | Nutrients | 2018 | 119 |
| 32 | IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation | Blood | 2013 | 114 |
| 33 | Phase Ib study of atezolizumab combined with cobimetinib in patients with solid tumors | Annals of Oncology | 2019 | 113 |
| 34 | Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. | Endocrinology | 1995 | 110 |
| 35 | Inhaled Corticosteroids and Risk of Tuberculosis in Patients with Respiratory Diseases | American Journal of Respiratory and Critical Care Medicine | 2011 | 110 |
| 36 | Basics and principles of cellular and systemic iron homeostasis | Molecular Aspects of Medicine | 2020 | 110 |
| 37 | Quality of Life, Dyspnea, and Functional Exercise Capacity Following a First Episode of Pulmonary Embolism: Results of the ELOPE Cohort Study | American Journal of Medicine | 2017 | 107 |
| 38 | Incidence and predictors of venous thromboembolism recurrence after a first isolated distal deep vein thrombosis | Journal of Thrombosis and Haemostasis | 2014 | 106 |
| 39 | Health-Related Quality of Life and Utility in Patients with Advanced Non–Small-Cell Lung Cancer: A Prospective Cross-Sectional Patient Survey in a Real-World Setting | Journal of Thoracic Oncology | 2013 | 100 |
| 40 | Structural and Functional Alterations of Subcutaneous Small Resistance Arteries in Severe Human Obesity | Obesity | 2010 | 98 |
| 41 | HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells | Free Radical Biology and Medicine | 2005 | 97 |
| 42 | The Post-Thrombotic Syndrome | Hematology American Society of Hematology Education Program | 2010 | 94 |
| 43 | The Herpes Simplex Virus 1-Encoded Envelope Glycoprotein B Activates NF-κB through the Toll-Like Receptor 2 and MyD88/TRAF6-Dependent Signaling Pathway | PLoS ONE | 2013 | 92 |
| 44 | The Interaction between HIV-1 Gag and Human Lysyl-tRNA Synthetase during Viral Assembly | Journal of Biological Chemistry | 2003 | 90 |
| 45 | Epidemiology of the post-thrombotic syndrome | Thrombosis Research | 2018 | 88 |
| 46 | Protocol for the PREHAB study--Pre-operative Rehabilitation for reduction of Hospitalization After coronary Bypass and valvular surgery: a randomised controlled trial | BMJ Open | 2015 | 87 |
| 47 | Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. | Endocrinology | 1995 | 85 |
| 48 | Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes | Blood | 2014 | 83 |
| 49 | High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial | PLoS ONE | 2015 | 83 |
| 50 | A complex retinoic acid response element in the uncoupling protein gene defines a novel role for retinoids in thermogenesis. | Endocrinology | 1996 | 80 |
