# | Title | Journal | Year | Citations |
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1 | CHARMM: The biomolecular simulation program | Journal of Computational Chemistry | 2009 | 7,077 |
2 | N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO | Nature Chemical Biology | 2011 | 2,936 |
3 | The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen | Cell | 1998 | 2,441 |
4 | Structure of Staphylococcal alpha -Hemolysin, a Heptameric Transmembrane Pore | Science | 1996 | 2,237 |
5 | UBIQUITIN-DEPENDENT PROTEIN DEGRADATION | Annual Review of Genetics | 1996 | 1,566 |
6 | Molecular mechanism of Thioflavin-T binding to amyloid fibrils | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2010 | 1,553 |
7 | N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions | Nature | 2015 | 1,482 |
8 | Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | Nature Genetics | 2000 | 1,403 |
9 | The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 | Nature | 1994 | 1,256 |
10 | BACTERIAL HEAVY METAL RESISTANCE: New Surprises | Annual Review of Microbiology | 1996 | 1,129 |
11 | Crystal structure of trp represser/operator complex at atomic resolution | Nature | 1988 | 996 |
12 | Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine | Nature Biotechnology | 2011 | 955 |
13 | Ubiquitin, proteasomes, and the regulation of intracellular protein degradation | Current Opinion in Cell Biology | 1995 | 859 |
14 | R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling | Cell | 2018 | 794 |
15 | THINKING ABOUT BACTERIAL POPULATIONS AS MULTICELLULAR ORGANISMS | Annual Review of Microbiology | 1998 | 775 |
16 | The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA | Nature | 2016 | 765 |
17 | An Evolutionarily Conserved Mechanism for Controlling the Efficiency of Protein Translation | Cell | 2010 | 759 |
18 | METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification | Cell Stem Cell | 2018 | 749 |
19 | Stem Cells | Cell | 2000 | 738 |
20 | Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 712 |
21 | Mechanisms of Site-Specific Recombination | Annual Review of Biochemistry | 2006 | 708 |
22 | The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae | Cell | 1990 | 684 |
23 | A new protease required for cell-cycle progression in yeast | Nature | 1999 | 672 |
24 | VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation | Cell Discovery | 2018 | 643 |
25 | N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein | Nucleic Acids Research | 2017 | 586 |
26 | The new enzymology of precursor processing endoproteases. | Journal of Biological Chemistry | 1992 | 574 |
27 | Insights into the Mechanism and Catalysis of the Native Chemical Ligation Reaction | Journal of the American Chemical Society | 2006 | 553 |
28 | Structural basis for the function and inhibition of an influenza virus proton channel | Nature | 2008 | 549 |
29 | Passage of Heme-Iron Across the Envelope of Staphylococcus aureus | Science | 2003 | 544 |
30 | Extraribosomal functions of ribosomal proteins | Trends in Biochemical Sciences | 1996 | 534 |
31 | Tissue-Specific Differences in Human Transfer RNA Expression | PLoS Genetics | 2006 | 508 |
32 | Infrared light excites cells by changing their electrical capacitance | Nature Communications | 2012 | 501 |
33 | The new enzymology of precursor processing endoproteases | Journal of Biological Chemistry | 1992 | 479 |
34 | Structure of a flavin-binding plant photoreceptor domain: Insights into light-mediated signal transduction | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 471 |
35 | How membrane proteins sense voltage | Nature Reviews Molecular Cell Biology | 2008 | 468 |
36 | m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade | Nature Communications | 2019 | 468 |
37 | The role of assembly in insulin's biosynthesis | Current Opinion in Structural Biology | 1998 | 467 |
38 | Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation | Science | 1992 | 464 |
39 | Structure and Signaling Mechanism of Per-ARNT-Sim Domains | Structure | 2009 | 457 |
40 | Plasma Membranes Contain Half the Phospholipid and 90% of the Cholesterol and Sphingomyelin in Cultured Human Fibroblasts | Journal of Biological Chemistry | 1989 | 451 |
41 | Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography | Science | 1997 | 445 |
42 | Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset | Blood | 2012 | 443 |
43 | The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase | Nature Structural Biology | 1995 | 442 |
44 | Gene targeting of BPAG1: Abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration | Cell | 1995 | 437 |
45 | Structure and Function of Plant Photoreceptors | Annual Review of Plant Biology | 2010 | 436 |
46 | An Empirical Polarizable Force Field Based on the Classical Drude Oscillator Model: Development History and Recent Applications | Chemical Reviews | 2016 | 434 |
47 | TULIPs: tunable, light-controlled interacting protein tags for cell biology | Nature Methods | 2012 | 433 |
48 | Visualization of arrestin recruitment by a G-protein-coupled receptor | Nature | 2014 | 433 |
49 | Acid blobs and negative noodles | Nature | 1988 | 428 |
50 | Efficient and quantitative high-throughput tRNA sequencing | Nature Methods | 2015 | 426 |