| # | Title | Journal | Year | Citations |
|---|
| 1 | Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE) | BMJ: British Medical Journal | 2006 | 1,236 |
| 2 | Titration and Implementation of Neurally Adjusted Ventilatory Assist in Critically Ill Patients | Chest | 2009 | 736 |
| 3 | Prevention of LPS-Induced Acute Lung Injury in Mice by Mesenchymal Stem Cells Overexpressing Angiopoietin 1 | PLoS Medicine | 2007 | 545 |
| 4 | How Does Empagliflozin Reduce Cardiovascular Mortality? Insights From a Mediation Analysis of the EMPA-REG OUTCOME Trial | Diabetes Care | 2018 | 534 |
| 5 | Predictive Factors, Management, and Clinical Outcomes of Coronary Obstruction Following Transcatheter Aortic Valve Implantation | Journal of the American College of Cardiology | 2013 | 502 |
| 6 | Practice variation and missed opportunities for reperfusion in ST-segment-elevation myocardial infarction: findings from the Global Registry of Acute Coronary Events (GRACE) | Lancet, The | 2002 | 496 |
| 7 | Acute Coronary Syndromes Without Chest Pain, An Underdiagnosed and Undertreated High-Risk Group | Chest | 2004 | 439 |
| 8 | Coronary angiographic morphology in myocardial infarction: A link between the pathogenesis of unstable angina and myocardial infarction | Journal of the American College of Cardiology | 1985 | 395 |
| 9 | Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis | Lancet, The | 2013 | 388 |
| 10 | Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial | Lancet, The | 2000 | 368 |
| 11 | Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease | Circulation | 2018 | 347 |
| 12 | Abnormal Aortic Valve Development in Mice Lacking Endothelial Nitric Oxide Synthase | Circulation | 2000 | 302 |
| 13 | Bone Morphogenetic Protein Receptor-2 Signaling Promotes Pulmonary Arterial Endothelial Cell Survival | Circulation Research | 2006 | 287 |
| 14 | Intracoronary thrombus and complex morphology in unstable angina. Relation to timing of angiography and in-hospital cardiac events. | Circulation | 1989 | 265 |
| 15 | Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. | Circulation Research | 1994 | 265 |
| 16 | Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification | JACC: Cardiovascular Interventions | 2016 | 257 |
| 17 | Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2 | Cardiovascular Research | 2001 | 255 |
| 18 | Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF121 (AdVEGF121) versus maximum medical treatment | Gene Therapy | 2006 | 244 |
| 19 | Factors Associated With Major Bleeding Events | Journal of the American College of Cardiology | 2014 | 212 |
| 20 | Empagliflozin Reduced Mortality and Hospitalization for Heart Failure Across the Spectrum of Cardiovascular Risk in the EMPA-REG OUTCOME Trial | Circulation | 2019 | 205 |
| 21 | ST segment shift in unstable angina: pathophysiology and association with coronary anatomy and hospital outcome | Journal of the American College of Cardiology | 1989 | 203 |
| 22 | Bone Marrow-Derived Mesenchymal Stromal Cells Express Cardiac-Specific Markers, Retain the Stromal Phenotype, and Do Not Become Functional Cardiomyocytes In Vitro | Stem Cells | 2008 | 202 |
| 23 | Randomized Evaluation of the Safety and Efficacy of Enoxaparin Versus Unfractionated Heparin in High-Risk Patients With Non-ST-Segment Elevation Acute Coronary Syndromes Receiving the Glycoprotein IIb/IIIa Inhibitor Eptifibatide | Circulation | 2003 | 200 |
| 24 | Adherence to evidence-based therapies after discharge for acute coronary syndromes: an ongoing prospective, observational study | American Journal of Medicine | 2004 | 198 |
| 25 | Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study | Lancet, The | 2017 | 187 |
| 26 | Detection of silent myocardial ischemia in diabetes mellitus | American Journal of Cardiology | 1991 | 178 |
| 27 | Association of Proton Pump Inhibitor Use on Cardiovascular Outcomes With Clopidogrel and Ticagrelor | Circulation | 2012 | 176 |
| 28 | Prognostic significance of elevated troponin i after percutaneous coronary intervention | Journal of the American College of Cardiology | 2002 | 170 |
| 29 | Bridging the gender gap: Insights from a contemporary analysis of sex-related differences in the treatment and outcomes of patients with acute coronary syndromes | American Heart Journal | 2012 | 168 |
| 30 | Factors influencing underutilization of evidence-based therapies in women | European Heart Journal | 2011 | 166 |
| 31 | Six-month outcomes in a multinational registry of patients hospitalized with an acute coronary syndrome (The Global Registry of Acute Coronary Events [GRACE]) | American Journal of Cardiology | 2004 | 165 |
| 32 | The expanded Global Registry of Acute Coronary Events: Baseline characteristics, management practices, and hospital outcomes of patients with acute coronary syndromes | American Heart Journal | 2009 | 165 |
| 33 | Angiogenic Actions of Angiopoietin-1 Require Endothelium-Derived Nitric Oxide | American Journal of Pathology | 2003 | 161 |
| 34 | Validation of the Global Registry of Acute Coronary Event (GRACE) risk score for in-hospital mortality in patients with acute coronary syndrome in Canada | American Heart Journal | 2009 | 160 |
| 35 | The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy | European Heart Journal | 2013 | 160 |
| 36 | 1-Year Outcomes After Edge-to-Edge Valve Repair for Symptomatic Tricuspid Regurgitation | JACC: Cardiovascular Interventions | 2019 | 160 |
| 37 | Protective Role of Angiopoietin-1 in Experimental Pulmonary Hypertension | Circulation Research | 2003 | 159 |
| 38 | Therapeutic Arteriogenesis by Ultrasound-Mediated VEGF 165 Plasmid Gene Delivery to Chronically Ischemic Skeletal Muscle | Circulation Research | 2007 | 158 |
| 39 | The Obesity Epidemic and Its Impact on Hypertension | Canadian Journal of Cardiology | 2012 | 158 |
| 40 | Placebo-Controlled, Randomized Clinical Trial of Azimilide for Prevention of Ventricular Tachyarrhythmias in Patients With an Implantable Cardioverter Defibrillator | Circulation | 2004 | 155 |
| 41 | Randomized trial of low molecular weight heparin (enoxaparin) versus unfractionated heparin for unstable coronary artery disease∗∗∗∗A list of participating ESSENCE Study Group investigators may be found in N Engl J Med 1997;337:447–52. | Journal of the American College of Cardiology | 2000 | 154 |
| 42 | Management Patterns in Relation to Risk Stratification Among Patients With Non–ST Elevation Acute Coronary Syndromes | Archives of Internal Medicine | 2007 | 147 |
| 43 | Contrast echocardiography for detection of pulmonary arteriovenous malformations | American Heart Journal | 2001 | 146 |
| 44 | Validation of a New Simple Scale to Measure Symptoms in Atrial Fibrillation | Circulation: Arrhythmia and Electrophysiology | 2009 | 145 |
| 45 | Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial | European Heart Journal | 2014 | 145 |
| 46 | Optimal medical therapy at discharge in patients with acute coronary syndromes: Temporal changes, characteristics, and 1-year outcome | American Heart Journal | 2007 | 141 |
| 47 | Defective Lung Vascular Development and Fatal Respiratory Distress in Endothelial NO Synthase-Deficient Mice | Circulation Research | 2004 | 134 |
| 48 | Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial | Diabetologia | 2018 | 133 |
| 49 | Association between QT dispersion and autonomic dysfunction in patients with diabetes mellitus | Journal of the American College of Cardiology | 1995 | 131 |
| 50 | In Vivo Collagen Turnover Following Experimental Balloon Angioplasty Injury and the Role of Matrix Metalloproteinases | Circulation Research | 1996 | 131 |
