| # | Title | Journal | Year | Citations |
|---|
| 1 | Carotenoids and human health | Pharmacological Research | 2007 | 1,530 |
| 2 | Not all patients want to participate in decision making | Journal of General Internal Medicine | 2005 | 927 |
| 3 | International guidelines for the diagnosis and management of hereditary haemorrhagic telangiectasia | Journal of Medical Genetics | 2011 | 887 |
| 4 | Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study | Lancet, The | 2005 | 873 |
| 5 | Inspiratory Muscle Unloading by Neurally Adjusted Ventilatory Assist During Maximal Inspiratory Efforts in Healthy Subjects | Chest | 2007 | 729 |
| 6 | Improvement of Sleep Apnea in Patients with Chronic Renal Failure Who Undergo Nocturnal Hemodialysis | New England Journal of Medicine | 2001 | 517 |
| 7 | Folate and carcinogenesis: evidence, mechanisms, and implications | Journal of Nutritional Biochemistry | 1999 | 496 |
| 8 | Contribution of the Intensive Care Unit Environment to Sleep Disruption in Mechanically Ventilated Patients and Healthy Subjects | American Journal of Respiratory and Critical Care Medicine | 2003 | 482 |
| 9 | Platelet-Activating Factor, PAF Acetylhydrolase, and Severe Anaphylaxis | New England Journal of Medicine | 2008 | 476 |
| 10 | Invited Review: Mechanisms of ventilator-induced lung injury: a perspective | Journal of Applied Physiology | 2000 | 469 |
| 11 | American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer | Blood Advances | 2021 | 431 |
| 12 | Two-Year Outcomes, Health Care Use, and Costs of Survivors of Acute Respiratory Distress Syndrome | American Journal of Respiratory and Critical Care Medicine | 2006 | 405 |
| 13 | Radial Versus Femoral Access for Coronary Interventions Across the Entire Spectrum of Patients With Coronary Artery Disease | JACC: Cardiovascular Interventions | 2016 | 385 |
| 14 | 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults | Canadian Journal of Cardiology | 2021 | 367 |
| 15 | A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis | Critical Care | 2011 | 364 |
| 16 | Contemporary outcome trends in the elderly undergoing percutaneous coronary interventions: Results in 7,472 octogenarians | Journal of the American College of Cardiology | 2000 | 359 |
| 17 | Oral antihyperglycemic therapy for type 2 diabetes mellitus | Cmaj | 2005 | 354 |
| 18 | Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone | Cmaj | 2009 | 345 |
| 19 | Cryoballoon or Radiofrequency Ablation for Atrial Fibrillation Assessed by Continuous Monitoring | Circulation | 2019 | 345 |
| 20 | Multiple sclerosis: clinical aspects | Current Opinion in Neurology | 2018 | 324 |
| 21 | Treatment of Obstructive Sleep Apnea with Nasal Continuous Positive Airway Pressure: Patient Compliance, Perception of Benefits, and Side Effects | The American Review of Respiratory Disease | 1992 | 315 |
| 22 | The Canadian Trial of Carbohydrates in Diabetes (CCD), a 1-y controlled trial of low-glycemic-index dietary carbohydrate in type 2 diabetes: no effect on glycated hemoglobin but reduction in C-reactive protein | American Journal of Clinical Nutrition | 2008 | 300 |
| 23 | Adjuvant Treatment and Onset of Menopause Predict Weight Gain After Breast Cancer Diagnosis | Journal of Clinical Oncology | 1999 | 278 |
| 24 | Parathyroid Hormone Secretion and Action: Evidence for Discrete Receptors for the Carboxyl-Terminal Region and Related Biological Actions of Carboxyl-Terminal Ligands | Endocrine Reviews | 2005 | 276 |
| 25 | Review of oral appliances for treatment of sleep-disordered breathing | Sleep and Breathing | 2007 | 271 |
| 26 | Transcriptional regulation of the endothelin-1 gene by TNF-alpha | American Journal of Physiology - Cell Physiology | 1992 | 264 |
| 27 | Knowledge translation is the use of knowledge in health care decision making | Journal of Clinical Epidemiology | 2011 | 262 |
| 28 | IScore | Circulation | 2011 | 261 |
| 29 | Human Pulmonary Circulation Is an Important Site for Both Clearance and Production of Endothelin-1 | Circulation | 1996 | 258 |
| 30 | Intra-islet insulin suppresses glucagon release via GABA-GABAA receptor system | Cell Metabolism | 2006 | 257 |
| 31 | Transcatheter Mitral Valve Replacement in Native Mitral Valve Disease With Severe Mitral Annular Calcification | JACC: Cardiovascular Interventions | 2016 | 257 |
| 32 | Effectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial | BMJ, The | 2021 | 250 |
| 33 | Stroke Prognostication using Age and NIH Stroke Scale | Neurology | 2013 | 246 |
| 34 | Management of cardiac arrest in pregnancy: A systematic review | Resuscitation | 2011 | 240 |
| 35 | THE GLYCAEMIC RESPONSE TO CARBOHYDRATE FOODS | Lancet, The | 1984 | 238 |
| 36 | Rabbit model for Chlamydia pneumoniae infection | Journal of Clinical Microbiology | 1997 | 234 |
| 37 | Homocysteine-Lowering Therapy and Stroke Risk, Severity, and Disability | Stroke | 2009 | 233 |
| 38 | VEGF Gene Therapy Fails to Improve Perfusion of Ischemic Myocardium in Patients With Advanced Coronary Disease: Results of the NORTHERN Trial | Molecular Therapy | 2009 | 232 |
| 39 | Intensive Hemodialysis Associates with Improved Pregnancy Outcomes | Journal of the American Society of Nephrology: JASN | 2014 | 223 |
| 40 | Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics. | Arteriosclerosis and Thrombosis: A Journal of Vascular Biology | 1993 | 218 |
| 41 | Quality of life improves with treatment in the Canadian Trial of Atrial Fibrillation | American Heart Journal | 2002 | 211 |
| 42 | Incidence of complications other than urinary incontinence or erectile dysfunction after radical prostatectomy or radiotherapy for prostate cancer: a population-based cohort study | Lancet Oncology, The | 2014 | 203 |
| 43 | Impact of Menopause on the Prevalence and Severity of Sleep Apnea | Chest | 2001 | 197 |
| 44 | The Expression of Endothelial Nitric-oxide Synthase Is Controlled by a Cell-specific Histone Code | Journal of Biological Chemistry | 2005 | 195 |
| 45 | Role of Nitric Oxide in the Angiogenic Response In Vitro to Basic Fibroblast Growth Factor | Circulation Research | 1998 | 192 |
| 46 | Development of trauma systems and effect on outcomes after injury | Lancet, The | 2004 | 187 |
| 47 | Malnutrition at Hospital Admission—Contributors and Effect on Length of Stay | Journal of Parenteral and Enteral Nutrition | 2016 | 187 |
| 48 | The impact of a gluten-free diet on adults with coeliac disease: results of a national survey | Journal of Human Nutrition and Dietetics | 2006 | 185 |
| 49 | Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis | Journal of Allergy and Clinical Immunology | 2013 | 185 |
| 50 | Does This Patient With Diabetes Have Osteomyelitis of the Lower Extremity? | JAMA - Journal of the American Medical Association | 2008 | 183 |
