| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel | Blood | 2017 | 4,375 |
| 3 | A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis | Cell | 1998 | 3,376 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 5 | Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial | Lancet, The | 2016 | 3,077 |
| 6 | Daily Interruption of Sedative Infusions in Critically Ill Patients Undergoing Mechanical Ventilation | New England Journal of Medicine | 2000 | 3,072 |
| 7 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit | Critical Care Medicine | 2013 | 3,066 |
| 8 | Impact of sleep debt on metabolic and endocrine function | Lancet, The | 1999 | 3,043 |
| 9 | bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death | Cell | 1993 | 2,976 |
| 10 | Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy | Science | 2015 | 2,782 |
| 11 | A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene | Science | 2006 | 2,739 |
| 12 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 13 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation | Cancer Cell | 2010 | 2,328 |
| 14 | Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity | Nature | 2015 | 2,130 |
| 15 | The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients | Science | 2018 | 2,027 |
| 16 | CTLA-4 can function as a negative regulator of T cell activation | Immunity | 1994 | 1,949 |
| 17 | Mitochondrial reactive oxygen species trigger hypoxia-induced transcription | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 1,724 |
| 18 | Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia | Journal of Biological Chemistry | 2000 | 1,697 |
| 19 | Head and Neck Cancer | New England Journal of Medicine | 1993 | 1,690 |
| 20 | Polycystic Ovary Syndrome | New England Journal of Medicine | 2005 | 1,689 |
| 21 | Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis | Nature Genetics | 2007 | 1,633 |
| 22 | Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab | Cell | 2017 | 1,515 |
| 23 | Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea | Nature Biotechnology | 2017 | 1,512 |
| 24 | Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10−/− mice | Nature | 2012 | 1,506 |
| 25 | A gene-based association method for mapping traits using reference transcriptome data | Nature Genetics | 2015 | 1,473 |
| 26 | Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease | Cell | 1996 | 1,450 |
| 27 | Up-Regulation of PD-L1, IDO, and T regs in the Melanoma Tumor Microenvironment Is Driven by CD8 + T Cells | Science Translational Medicine | 2013 | 1,447 |
| 28 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 29 | The Antiphospholipid Syndrome | New England Journal of Medicine | 2002 | 1,411 |
| 30 | Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | Nature Genetics | 2000 | 1,403 |
| 31 | Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages | Science | 1994 | 1,400 |
| 32 | Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial | Lancet Oncology, The | 2016 | 1,369 |
| 33 | pRRophetic: An R Package for Prediction of Clinical Chemotherapeutic Response from Tumor Gene Expression Levels | PLoS ONE | 2014 | 1,363 |
| 34 | The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota | Science | 2011 | 1,354 |
| 35 | Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria | Cell | 1997 | 1,345 |
| 36 | Failure to Regulate TNF-Induced NF-kappa B and Cell Death Responses in A20-Deficient Mice | Science | 2000 | 1,325 |
| 37 | STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors | Immunity | 2014 | 1,325 |
| 38 | Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing | Cell Metabolism | 2005 | 1,321 |
| 39 | A Meta-Analysis of Interventions to Reduce Loneliness | Personality and Social Psychology Review | 2011 | 1,289 |
| 40 | Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance | Diabetes | 1992 | 1,263 |
| 41 | Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes | Nature | 2010 | 1,261 |
| 42 | A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization | Cell | 1988 | 1,246 |
| 43 | Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) | Nature | 1996 | 1,240 |
| 44 | Two-stage residual inclusion estimation: Addressing endogeneity in health econometric modeling | Journal of Health Economics | 2008 | 1,212 |
| 45 | IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation | Immunity | 1998 | 1,191 |
| 46 | Modulation of tryptophan catabolism by regulatory T cells | Nature Immunology | 2003 | 1,172 |
| 47 | The molecular portraits of breast tumors are conserved across microarray platforms | BMC Genomics | 2006 | 1,169 |
| 48 | Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS | PLoS Genetics | 2010 | 1,161 |
| 49 | FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase | Cancer Cell | 2017 | 1,139 |
| 50 | The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response | Cell | 1998 | 1,138 |
