# | Title | Journal | Year | Citations |
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1 | Vitamin B12 deficiency after esophagectomy with gastric tube reconstruction for esophageal cancer | Ecological Management and Restoration | 2017 | 1,450 |
2 | Screening and prostate cancer mortality: results of the European Randomised Study of Screening for Prostate Cancer (ERSPC) at 13 years of follow-up | Lancet, The | 2014 | 1,261 |
3 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
4 | Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus | Clinical Pharmacology and Therapeutics | 2003 | 580 |
5 | Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis | Science Translational Medicine | 2016 | 428 |
6 | A Multicenter Study of [-2]Pro-Prostate Specific Antigen Combined With Prostate Specific Antigen and Free Prostate Specific Antigen for Prostate Cancer Detection in the 2.0 to 10.0 ng/ml Prostate Specific Antigen Range | Journal of Urology | 2011 | 408 |
7 | Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report | Therapeutic Drug Monitoring | 2019 | 374 |
8 | Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction | Nature Genetics | 2021 | 264 |
9 | Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics | Clinical Pharmacokinetics | 2018 | 263 |
10 | DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis | Lancet Oncology, The | 2018 | 238 |
11 | The Prostate Health Index Selectively Identifies Clinically Significant Prostate Cancer | Journal of Urology | 2015 | 228 |
12 | Prostate-Specific Antigen (PSA) Isoform p2PSA in Combination with Total PSA and Free PSA Improves Diagnostic Accuracy in Prostate Cancer Detection | European Urology | 2010 | 223 |
13 | The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients | European Urology | 2017 | 213 |
14 | The Generation R Study Biobank: a resource for epidemiological studies in children and their parents | European Journal of Epidemiology | 2007 | 212 |
15 | A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients | Clinical Chemistry | 2011 | 211 |
16 | Genetic variation in the organic cation transporter 1 is associated with metformin response in patients with diabetes mellitus | Pharmacogenomics Journal | 2009 | 198 |
17 | The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation | Clinical Pharmacokinetics | 2014 | 186 |
18 | Pharmacokinetics of intravenous immunoglobulin and outcome in Guillain‐Barré syndrome | Annals of Neurology | 2009 | 183 |
19 | Significance of elevated cobalamin (vitamin B12) levels in blood | Clinical Biochemistry | 2003 | 182 |
20 | CYP3A4*22: promising newly identifiedCYP3A4variant allele for personalizing pharmacotherapy | Pharmacogenomics | 2013 | 178 |
21 | The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increases the chance of pregnancy | Fertility and Sterility | 2010 | 174 |
22 | Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin | Nature Genetics | 2016 | 165 |
23 | Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk? | Fertility and Sterility | 2014 | 154 |
24 | Pharmacogenetic Pathway Analysis of Docetaxel Elimination | Clinical Pharmacology and Therapeutics | 2009 | 148 |
25 | Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors’ dose requirements and trough blood levels in stable renal transplant patients | Pharmacogenomics | 2011 | 139 |
26 | Genetic Variation in the CYP2D6 Gene Is Associated With a Lower Heart Rate and Blood Pressure in β-Blocker Users | Clinical Pharmacology and Therapeutics | 2009 | 130 |
27 | A Randomized Controlled Trial Comparing the Efficacy of Cyp3a5 Genotype‐Based With Body‐Weight‐Based Tacrolimus Dosing After Living Donor Kidney Transplantation | American Journal of Transplantation | 2016 | 129 |
28 | Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines | European Journal of Human Genetics | 2020 | 127 |
29 | Homocysteine and DNA methylation: A review of animal and human literature | Molecular Genetics and Metabolism | 2014 | 121 |
30 | The Mediterranean diet and fetal size parameters: the Generation R Study | British Journal of Nutrition | 2012 | 120 |
31 | Determinants of hair cortisol and hair cortisone concentrations in adults | Psychoneuroendocrinology | 2015 | 118 |
32 | Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads | European Journal of Clinical Nutrition | 2007 | 113 |
33 | Cytochrome P450 2C9 *2 and *3 Polymorphisms and the Dose and Effect of Sulfonylurea in Type II Diabetes Mellitus | Clinical Pharmacology and Therapeutics | 2008 | 113 |
34 | The CYP2D6*4 polymorphism affects breast cancer survival in tamoxifen users | Breast Cancer Research and Treatment | 2009 | 108 |
35 | Flow cytometric characterization of cerebrospinal fluid cells | Cytometry Part B - Clinical Cytometry | 2011 | 108 |
36 | Mast cells are involved in inflammatory reactions during Complex Regional Pain Syndrome type 1 | Immunology Letters | 2004 | 107 |
37 | The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects | Clinical Epigenetics | 2015 | 106 |
38 | Pharmacogenetic aspects of the use of tacrolimus in renal transplantation: recent developments and ethnic considerations | Expert Opinion on Drug Metabolism and Toxicology | 2016 | 106 |
39 | Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants | British Journal of Clinical Pharmacology | 2008 | 102 |
40 | C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study | American Journal of Obstetrics and Gynecology | 2011 | 100 |
41 | Folic acid and homocysteine affect neural crest and neuroepithelial cell outgrowth and differentiation in vitro | Developmental Dynamics | 2003 | 96 |
42 | A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics | PLoS ONE | 2016 | 96 |
43 | CYP450 pharmacogenetics for personalizing cancer therapy | Drug Resistance Updates | 2008 | 94 |
44 | Prognostic Value of N-Terminal Pro-B-Type Natriuretic Peptide, Troponin-T, and Growth-Differentiation Factor 15 in Adult Congenital Heart Disease | Circulation | 2017 | 93 |
45 | The risk of overanticoagulation in patients with cytochrome P450 CYP2C9*2 or CYP2C9*3 alleles on acenocoumarol or phenprocoumon | Pharmacogenetics and Genomics | 2004 | 91 |
46 | CYP3A5 variant allele frequencies in Dutch Caucasians | Clinical Chemistry | 2002 | 91 |
47 | Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology | Therapeutic Drug Monitoring | 2021 | 89 |
48 | Reference ranges and determinants of total hCG levels during pregnancy: the Generation R Study | European Journal of Epidemiology | 2015 | 88 |
49 | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants | Nature Communications | 2018 | 88 |
50 | Maternal hyperhomocysteinaemia is a risk factor for congenital heart disease | BJOG: an International Journal of Obstetrics and Gynaecology | 2006 | 87 |