| # | Title | Journal | Year | Citations |
|---|
| 1 | Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel | Blood | 2017 | 4,375 |
| 2 | Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet | Blood | 2010 | 2,963 |
| 3 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation | Cancer Cell | 2010 | 2,328 |
| 4 | Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters | Cell | 2008 | 1,504 |
| 5 | Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis | Thrombosis Research | 2020 | 1,357 |
| 6 | Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia | Nature | 2011 | 1,354 |
| 7 | Prognostically Useful Gene-Expression Profiles in Acute Myeloid Leukemia | New England Journal of Medicine | 2004 | 1,232 |
| 8 | Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161 | Nature Immunology | 2011 | 1,024 |
| 9 | Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration | Nature | 2015 | 818 |
| 10 | International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data | Blood | 2022 | 814 |
| 11 | Suppression of non-small cell lung tumor development by the let-7 microRNA family | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 808 |
| 12 | DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia | Cancer Cell | 2010 | 737 |
| 13 | Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism | JAMA - Journal of the American Medical Association | 2014 | 680 |
| 14 | Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management | Leukemia | 2010 | 677 |
| 15 | Risk of progression and survival in multiple myeloma relapsing after therapy with IMiDs and bortezomib: A multicenter international myeloma working group study | Leukemia | 2012 | 664 |
| 16 | Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function | Annual Review of Immunology | 2012 | 619 |
| 17 | Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19) | Nature Communications | 2021 | 601 |
| 18 | Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells | Nature Immunology | 2009 | 595 |
| 19 | A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia | Cell | 2014 | 571 |
| 20 | Fibrin structure and wound healing | Journal of Thrombosis and Haemostasis | 2006 | 546 |
| 21 | Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome | Blood | 2009 | 516 |
| 22 | IMWG consensus on risk stratification in multiple myeloma | Leukemia | 2014 | 500 |
| 23 | Prognostic Index for Adult Patients With Acute Myeloid Leukemia in First Relapse | Journal of Clinical Oncology | 2005 | 463 |
| 24 | Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom? | Blood | 2007 | 438 |
| 25 | Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33‐positive acute myeloid leukemia in first recurrence | Cancer | 2005 | 429 |
| 26 | Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet | Blood | 2019 | 393 |
| 27 | Von Willebrand’s Disease | New England Journal of Medicine | 2016 | 389 |
| 28 | Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib | Blood | 2007 | 379 |
| 29 | MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia | Blood | 2008 | 376 |
| 30 | The novel AML stem cell–associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells | Blood | 2007 | 361 |
| 31 | Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study | Lancet, The | 2017 | 357 |
| 32 | Effect of Priming with Granulocyte Colony-Stimulating Factor on the Outcome of Chemotherapy for Acute Myeloid Leukemia | New England Journal of Medicine | 2003 | 356 |
| 33 | The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach | Nature Reviews Clinical Oncology | 2012 | 352 |
| 34 | Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value | Blood | 2010 | 345 |
| 35 | Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity | Blood | 2011 | 341 |
| 36 | Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7 | EMBO Journal | 2009 | 340 |
| 37 | Coagulation disorders after traumatic brain injury | Acta Neurochirurgica | 2008 | 331 |
| 38 | Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin | Nature Genetics | 2010 | 323 |
| 39 | Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia | Nature Medicine | 2016 | 322 |
| 40 | The impact of JAK2 and MPL mutations on diagnosis and prognosis of splanchnic vein thrombosis: a report on 241 cases | Blood | 2008 | 319 |
| 41 | New insights into the molecular mechanisms of the fibrinolytic system | Journal of Thrombosis and Haemostasis | 2009 | 315 |
| 42 | 2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party | Blood | 2021 | 305 |
| 43 | Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis | Blood | 2012 | 303 |
| 44 | Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms | Science Translational Medicine | 2018 | 299 |
| 45 | Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group | Leukemia | 2013 | 294 |
| 46 | Outpatient treatment in patients with acute pulmonary embolism: the Hestia Study | Journal of Thrombosis and Haemostasis | 2011 | 291 |
| 47 | European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications | Haematologica | 2015 | 289 |
| 48 | International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation | Blood | 2011 | 282 |
| 49 | The miR-144/451 locus is required for erythroid homeostasis | Journal of Experimental Medicine | 2010 | 277 |
| 50 | GATA-2 Plays Two Functionally Distinct Roles during the Ontogeny of Hematopoietic Stem Cells | Journal of Experimental Medicine | 2004 | 268 |
