| # | Title | Journal | Year | Citations |
|---|
| 1 | Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA | Science Translational Medicine | 2012 | 1,086 |
| 2 | CD133, a novel marker for human prostatic epithelial stem cells | Journal of Cell Science | 2004 | 714 |
| 3 | Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci | Nature Genetics | 2018 | 652 |
| 4 | Cancer therapy shapes the fitness landscape of clonal hematopoiesis | Nature Genetics | 2020 | 367 |
| 5 | Familial gastric cancer: overview and guidelines for management | Journal of Medical Genetics | 1999 | 344 |
| 6 | Psychological consequences of predictive genetic testing: a systematic review | European Journal of Human Genetics | 2000 | 337 |
| 7 | Years of life lost (YLL) from cancer is an important measure of population burden — and should be considered when allocating research funds | British Journal of Cancer | 2005 | 312 |
| 8 | Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin | Gastroenterology | 2004 | 308 |
| 9 | Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality | JAMA - Journal of the American Medical Association | 2018 | 296 |
| 10 | MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study | Lancet Oncology, The | 2021 | 268 |
| 11 | Dynamic contrast-enhanced MRI as a predictor of tumour response to radiotherapy | Lancet Oncology, The | 2007 | 249 |
| 12 | Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening | Journal of Pathology | 2004 | 242 |
| 13 | Identification of germ-line E-cadherin mutations in gastric cancer families of European origin | Cancer Research | 1998 | 241 |
| 14 | Mechanisms of metabolic dysfunction in cancer-associated cachexia | Genes and Development | 2016 | 239 |
| 15 | PD-L1 protein expression in breast cancer is rare, enriched in basal-like tumours and associated with infiltrating lymphocytes | Annals of Oncology | 2015 | 234 |
| 16 | Prostate-cancer mortality in the USA and UK in 1975–2004: an ecological study | Lancet Oncology, The | 2008 | 231 |
| 17 | Diffusion Tensor Imaging of Brain Tumours at 3T: A Potential Tool for Assessing White Matter Tract Invasion? | Clinical Radiology | 2003 | 224 |
| 18 | Short term outcomes of prostate biopsy in men tested for cancer by prostate specific antigen: prospective evaluation within ProtecT study | BMJ: British Medical Journal | 2012 | 211 |
| 19 | Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index | Clinical Cancer Research | 2006 | 188 |
| 20 | Performance status score: do patients and their oncologists agree? | British Journal of Cancer | 2003 | 179 |
| 21 | Genome-driven integrated classification of breast cancer validated in over 7,500 samples | Genome Biology | 2014 | 178 |
| 22 | Recommendations for standardized pathological characterization of residual disease for neoadjuvant clinical trials of breast cancer by the BIG-NABCG collaboration | Annals of Oncology | 2015 | 177 |
| 23 | Alterations in VHL as potential biomarkers in renal-cell carcinoma | Nature Reviews Clinical Oncology | 2010 | 149 |
| 24 | Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in theXenopusretina | Development (Cambridge) | 2002 | 144 |
| 25 | Semiquantitative and Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging Measurements Predict Radiation Response in Cervix Cancer | International Journal of Radiation Oncology Biology Physics | 2009 | 140 |
| 26 | Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity | Aging Cell | 2020 | 131 |
| 27 | ICUD-EAU International Consultation on Kidney Cancer 2010: Treatment of Metastatic Disease | European Urology | 2011 | 125 |
| 28 | The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus | Development (Cambridge) | 2003 | 122 |
| 29 | The IGF Pathway Regulates Head Formation by Inhibiting Wnt Signaling in Xenopus | Developmental Biology | 2002 | 111 |
| 30 | Colorectal liver metastases: Current management and future perspectives | World Journal of Clinical Oncology | 2020 | 98 |
| 31 | Nuclear chaperones | Seminars in Cell and Developmental Biology | 2000 | 94 |
| 32 | Adjuvant Therapy in Renal Cell Carcinoma—Past, Present, and Future | Seminars in Oncology | 2013 | 94 |
| 33 | Exploring treatment preferences facilitated recruitment to randomized controlled trials | Journal of Clinical Epidemiology | 2011 | 93 |
| 34 | Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas | European Radiology | 2004 | 92 |
| 35 | β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation | Oncogene | 2011 | 92 |
| 36 | Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants | Nature Communications | 2018 | 88 |
| 37 | Medical treatment of renal cancer: new horizons | British Journal of Cancer | 2016 | 83 |
| 38 | Effects of Collection and Processing Procedures on Plasma Circulating Cell-Free DNA from Cancer Patients | Journal of Molecular Diagnostics | 2018 | 81 |
| 39 | The EPTN consensus-based atlas for CT- and MR-based contouring in neuro-oncology | Radiotherapy and Oncology | 2018 | 80 |
| 40 | Adjuvant Vascular Endothelial Growth Factor–targeted Therapy in Renal Cell Carcinoma: A Systematic Review and Pooled Analysis | European Urology | 2018 | 77 |
| 41 | Ubiquitylation on Canonical and Non-canonical Sites Targets the Transcription Factor Neurogenin for Ubiquitin-mediated Proteolysis | Journal of Biological Chemistry | 2009 | 72 |
| 42 | A randomised, placebo-controlled trial of weekly paclitaxel and saracatinib (AZD0530) in platinum-resistant ovarian, fallopian tube or primary peritoneal cancer | Annals of Oncology | 2014 | 71 |
| 43 | Guidelines for the first line management of classical Hodgkin lymphoma | British Journal of Haematology | 2014 | 70 |
| 44 | Intra-tumour genetic heterogeneity and poor chemoradiotherapy response in cervical cancer | British Journal of Cancer | 2011 | 69 |
| 45 | Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans | Human Molecular Genetics | 2015 | 67 |
| 46 | Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer | Breast Cancer Research | 2016 | 66 |
| 47 | Accelerated hypo-fractionated radiotherapy for non small cell lung cancer: Results from 4 UK centres | Radiotherapy and Oncology | 2013 | 63 |
| 48 | Radiogenomics: the search for genetic predictors of radiotherapy response | Future Oncology | 2014 | 63 |
| 49 | Change in Patterns of Failure After Image-Guided Brachytherapy for Cervical Cancer: Analysis From the RetroEMBRACE Study | International Journal of Radiation Oncology Biology Physics | 2019 | 62 |
| 50 | Associations between an Obesity Related Genetic Variant (FTO rs9939609) and Prostate Cancer Risk | PLoS ONE | 2010 | 61 |
