| # | Title | Journal | Year | Citations |
|---|
| 1 | ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment | Journal of Crohn's and Colitis | 2020 | 741 |
| 2 | The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease | Journal of Crohn's and Colitis | 2016 | 577 |
| 3 | ECCO Guidelines on Therapeutics in Crohn’s Disease: Surgical Treatment | Journal of Crohn's and Colitis | 2020 | 478 |
| 4 | Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study | The Lancet Gastroenterology and Hepatology | 2019 | 431 |
| 5 | Abnormal colonic fermentation in irritable bowel syndrome | Lancet, The | 1998 | 430 |
| 6 | Increased nitric oxide synthesis in ulcerative colitis | Lancet, The | 1993 | 347 |
| 7 | IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting | Nature Reviews Gastroenterology and Hepatology | 2019 | 312 |
| 8 | Prebiotic carbohydrates modify the mucosa associated microflora of the human large bowel | Gut | 2004 | 296 |
| 9 | ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment | Journal of Crohn's and Colitis | 2022 | 288 |
| 10 | HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn’s Disease | Gastroenterology | 2020 | 249 |
| 11 | Isolation of Helicobacter pylori from feces of patients with dyspepsia in the United Kingdom | Gastroenterology | 1994 | 232 |
| 12 | Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable bowel syndrome | Digestive Diseases and Sciences | 2002 | 196 |
| 13 | Treatment of active Crohn's disease by exclusion diet: East Anglian Multicentre Controlled Trial | Lancet, The | 1993 | 192 |
| 14 | Review article: the dietary management of Crohn's disease | Alimentary Pharmacology and Therapeutics | 1997 | 132 |
| 15 | Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease | JAMA - Journal of the American Medical Association | 2019 | 129 |
| 16 | Somatic Evolution in Non-neoplastic IBD-Affected Colon | Cell | 2020 | 122 |
| 17 | ECCO Guidelines on Therapeutics in Ulcerative Colitis: Surgical Treatment | Journal of Crohn's and Colitis | 2022 | 120 |
| 18 | Use of sirolimus (rapamycin) to treat refractory Crohn's disease | Gut | 2008 | 118 |
| 19 | The Pathogenesis of Extraintestinal Manifestations: Implications for IBD Research, Diagnosis, and Therapy | Journal of Crohn's and Colitis | 2019 | 112 |
| 20 | Long-chain triglycerides reduce the efficacy ofenteral feeds in patients with active Crohn's disease | Clinical Nutrition | 1995 | 109 |
| 21 | Systematic review: the use of mesalazine in inflammatory bowel disease | Alimentary Pharmacology and Therapeutics | 2006 | 106 |
| 22 | Irritable bowel syndrome: is the search for lactose intolerance justified? | European Journal of Gastroenterology and Hepatology | 2001 | 105 |
| 23 | Colonoscopic Hydrostatic Balloon Dilatation of Crohn's Strictures | Journal of Clinical Gastroenterology | 2001 | 86 |
| 24 | The skinny on cocaine: Insights into eating behavior and body weight in cocaine-dependent men | Appetite | 2013 | 75 |
| 25 | Neuronal COX-2 expression in human myenteric plexus in active inflammatory bowel disease | Gut | 2001 | 73 |
| 26 | Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study | International Immunopharmacology | 2005 | 68 |
| 27 | Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet | Gut | 2022 | 63 |
| 28 | Instability in the faecal flora of a patient suffering from food-related irritable bowel syndrome | Journal of Medical Microbiology | 1987 | 62 |
| 29 | The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon | Journal of Clinical Pathology | 2001 | 58 |
| 30 | Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives | The Lancet Gastroenterology and Hepatology | 2022 | 57 |
| 31 | Nutritional Aspects of Dissimilatory Sulfate Reduction in the Human Large Intestine | Current Microbiology | 1997 | 56 |
| 32 | Genetic association between NLRP3 variants and Crohnʼs disease does not replicate in a large UK panel | Inflammatory Bowel Diseases | 2011 | 56 |
| 33 | The Relative Merits of Acute Phase Proteins in the Recognition of Inflammatory Conditions | Annals of Clinical Biochemistry | 1988 | 54 |
| 34 | Epidermal Growth Factor Stimulates Synthesis and Secretion of Mucus Glycoproteins in Human Gastric Mucosa | Clinical Science | 1990 | 52 |
| 35 | The current status of small bowel transplantation in the UK and internationally | Gut | 2005 | 51 |
| 36 | Distribution of Glutaminase and Glutamine Synthetase Activities in the Human Gastrointestinal Tract | Clinical Science | 1998 | 49 |
| 37 | Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts | Journal of Medical Genetics | 2007 | 47 |
| 38 | Perioperative Dietary Therapy in Inflammatory Bowel Disease | Journal of Crohn's and Colitis | 2020 | 46 |
| 39 | In VitroEffects of Mucin Fermentation on the Growth of Human Colonic Sulphate-Reducing Bacteria | Anaerobe | 1996 | 45 |
| 40 | Three-year prospective validation of a pre-endoscopic risk stratification in patients with acute upper-gastrointestinal haemorrhage | European Journal of Gastroenterology and Hepatology | 2002 | 45 |
| 41 | The Association of Geriatric Syndromes with Hospital Outcomes | Journal of Hospital Medicine | 2017 | 43 |
| 42 | Nitric oxide affects mammalian distal colonic smooth muscle by tonic neural inhibition | British Journal of Pharmacology | 1993 | 41 |
| 43 | Faecal Biomarkers in Inflammatory Bowel Diseases: Calprotectin Versus Lipocalin-2—a Comparative Study | Journal of Crohn's and Colitis | 2021 | 40 |
| 44 | Genetic variants in TNF-α but not DLG5 are associated with inflammatory bowel disease in a large United Kingdom cohort | Inflammatory Bowel Diseases | 2006 | 39 |
| 45 | Results of the Seventh Scientific Workshop of ECCO: Precision Medicine in IBD—Disease Outcome and Response to Therapy | Journal of Crohn's and Colitis | 2021 | 39 |
| 46 | Endoscopic balloon dilatation of duodenal strictures in Crohn’s disease | Postgraduate Medical Journal | 1995 | 37 |
| 47 | Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease | Nature Communications | 2020 | 37 |
| 48 | A 3-month, double-blind, controlled trial of feeding with sucrose polyester in human volunteers | British Journal of Nutrition | 1998 | 35 |
| 49 | Comparing outcome of radiofrequency ablation in Barrett’s with high grade dysplasia and intramucosal carcinoma: a prospective multicenter UK registry | Endoscopy | 2015 | 32 |
| 50 | Helicobacter pylori increases gastric antral juxtamucosal pH | Digestive Diseases and Sciences | 1993 | 29 |
