| # | Title | Journal | Year | Citations |
|---|
| 1 | Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 1,471 |
| 2 | Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. | Journal of Experimental Medicine | 1987 | 604 |
| 3 | The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis | EMBO Journal | 2011 | 530 |
| 4 | Viral mimicry of cytokines, chemokines and their receptors | Nature Reviews Immunology | 2003 | 510 |
| 5 | MALT lymphoma: from morphology to molecules | Nature Reviews Cancer | 2004 | 461 |
| 6 | Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice | Nature | 2011 | 443 |
| 7 | The Androgen Receptor Induces a Distinct Transcriptional Program in Castration-Resistant Prostate Cancer in Man | Cancer Cell | 2013 | 354 |
| 8 | Promiscuity and the single receptor: NKG2D | Nature Reviews Immunology | 2007 | 352 |
| 9 | Virus genomes reveal factors that spread and sustained the Ebola epidemic | Nature | 2017 | 346 |
| 10 | Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis | Nature Cancer | 2020 | 339 |
| 11 | Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function | Nature | 2012 | 331 |
| 12 | Pilocytic astrocytoma: pathology, molecular mechanisms and markers | Acta Neuropathologica | 2015 | 328 |
| 13 | Clinical features and natural history of Beckwith‐Wiedemann syndrome: presentation of 74 new cases | Clinical Genetics | 1994 | 303 |
| 14 | Tumour genomic and microenvironmental heterogeneity for integrated prediction of 5-year biochemical recurrence of prostate cancer: a retrospective cohort study | Lancet Oncology, The | 2014 | 291 |
| 15 | Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus | Nature Medicine | 2012 | 285 |
| 16 | Molecular pathological classification of colorectal cancer | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2016 | 276 |
| 17 | Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion | PLoS Pathogens | 2021 | 268 |
| 18 | Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study | EBioMedicine | 2015 | 260 |
| 19 | CD40 Is a Cellular Receptor Mediating Mycobacterial Heat Shock Protein 70 Stimulation of CC-Chemokines | Immunity | 2001 | 253 |
| 20 | Somatic mutations and clonal dynamics in healthy and cirrhotic human liver | Nature | 2019 | 251 |
| 21 | Frequent promoter hypermethylation and low expression of theMGMTgene in oligodendroglial tumors | International Journal of Cancer | 2005 | 246 |
| 22 | Alterations of the Tumor Suppressor Genes CDKN2A (p16), p14, CDKN2B (p15), and CDKN2C (p18) in Atypical and Anaplastic Meningiomas | American Journal of Pathology | 2001 | 243 |
| 23 | The mechanism of resistance to favipiravir in influenza | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 243 |
| 24 | Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen | Cell Host and Microbe | 2014 | 237 |
| 25 | Evolution of enhanced innate immune evasion by SARS-CoV-2 | Nature | 2022 | 237 |
| 26 | Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease | Immunity | 2021 | 230 |
| 27 | Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses | Blood | 2007 | 227 |
| 28 | Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS | Neuroscience | 2002 | 226 |
| 29 | Norovirus gene expression and replication | Journal of General Virology | 2014 | 225 |
| 30 | The ageing of bruises: A review and study of the colour changes with time | Forensic Science International | 1991 | 223 |
| 31 | Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection | Gastroenterology | 2005 | 212 |
| 32 | Polypeptides specified by the influenza virus genome | Virology | 1976 | 211 |
| 33 | Deregulation of the p14ARF/MDM2/p53 pathway is a prerequisite for human astrocytic gliomas with G1-S transition control gene abnormalities | Cancer Research | 2000 | 208 |
| 34 | Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days | Clinical Infectious Diseases | 2016 | 201 |
| 35 | SV40-53K antigen: A possible role for 53K in normal cells | Virology | 1981 | 196 |
| 36 | Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice | Nature Genetics | 2011 | 194 |
| 37 | Transcriptional slippage in the positive‐sense RNA virus family Potyviridae | EMBO Reports | 2015 | 192 |
| 38 | Identification of MicroRNAs From the miR-371∼373 and miR-302 Clusters as Potential Serum Biomarkers of Malignant Germ Cell Tumors | American Journal of Clinical Pathology | 2011 | 186 |
| 39 | The Mutation Rate and Variability of Eukaryotic Viruses: An Analytical Review | Journal of General Virology | 1987 | 182 |
| 40 | Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia | Nature Genetics | 2011 | 182 |
| 41 | Advances in Norovirus Biology | Cell Host and Microbe | 2014 | 182 |
| 42 | Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation | EMBO Journal | 2002 | 177 |
| 43 | Rotaviruses Associate with Cellular Lipid Droplet Components To Replicate in Viroplasms, and Compounds Disrupting or Blocking Lipid Droplets Inhibit Viroplasm Formation and Viral Replication | Journal of Virology | 2010 | 174 |
| 44 | A single gene determines the host range of influenza virus | Nature | 1977 | 172 |
| 45 | Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis | Nature Genetics | 2011 | 172 |
| 46 | Normothermic Perfusion in the Assessment and Preservation of Declined Livers Before Transplantation | Transplantation | 2017 | 171 |
| 47 | The immunogenicity of chimeric antibodies. | Journal of Experimental Medicine | 1989 | 170 |
| 48 | p53 immunohistochemistry is an accurate surrogate for TP53 mutational analysis in endometrial carcinoma biopsies | Journal of Pathology | 2020 | 164 |
| 49 | The human cytomegalovirus gene product US6 inhibits ATP binding by TAP | EMBO Journal | 2001 | 155 |
| 50 | Brief report: Primary human herpesvirus 6 infection in a patient following liver transplantation from a seropositive donor | Journal of Medical Virology | 1989 | 154 |
