| # | Title | Journal | Year | Citations |
|---|
| 1 | Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses | Journal of Experimental Medicine | 2008 | 531 |
| 2 | In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression | Journal of Experimental Medicine | 2009 | 461 |
| 3 | The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo | PLoS Pathogens | 2015 | 445 |
| 4 | Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses | Journal of Experimental Medicine | 2007 | 428 |
| 5 | Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know | Nature Medicine | 2004 | 426 |
| 6 | Dominant TNF-α+ Mycobacterium tuberculosis–specific CD4+ T cell responses discriminate between latent infection and active disease | Nature Medicine | 2011 | 380 |
| 7 | Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1–infected subjects with progressive disease: changes after antiretroviral therapy | Blood | 2004 | 345 |
| 8 | Inadequate T follicular cell help impairs B cell immunity during HIV infection | Nature Medicine | 2013 | 342 |
| 9 | Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 287 |
| 10 | HIV-1-specific IFN-γ/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 277 |
| 11 | An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses | Journal of Experimental Medicine | 2008 | 273 |
| 12 | Functional Heterogeneity of Memory CD4 T Cell Responses in Different Conditions of Antigen Exposure and Persistence | Journal of Immunology | 2005 | 271 |
| 13 | Functional signatures of protective antiviral T‐cell immunity in human virus infections | Immunological Reviews | 2006 | 256 |
| 14 | Tuberculosis comorbidity with communicable and non-communicable diseases: integrating health services and control efforts | Lancet Infectious Diseases, The | 2013 | 246 |
| 15 | Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection? | Journal of Viral Hepatitis | 1999 | 229 |
| 16 | IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets | Journal of Allergy and Clinical Immunology | 2009 | 211 |
| 17 | Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases | Nature Reviews Immunology | 2006 | 190 |
| 18 | MEDICINE: Enhanced: The Need for a Global HIV Vaccine Enterprise | Science | 2003 | 186 |
| 19 | Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still’s disease | Annals of the Rheumatic Diseases | 2018 | 181 |
| 20 | Mycobacterium tuberculosis‐specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease | European Journal of Immunology | 2013 | 172 |
| 21 | IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor α subunit CD25 | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 171 |
| 22 | Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load | European Journal of Immunology | 2004 | 169 |
| 23 | IgE to food allergens are highly prevalent in patients allergic to pollens, with and without symptoms of food allergy | Clinical and Experimental Allergy | 1994 | 157 |
| 24 | Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome | Journal of Clinical Immunology | 2018 | 156 |
| 25 | Strong EBV-specific CD8+ T-cell response in patients with early multiple sclerosis | Brain | 2008 | 150 |
| 26 | Phase I Malaria Vaccine Trial with a Long Synthetic Peptide Derived from the Merozoite Surface Protein 3 Antigen | Infection and Immunity | 2005 | 141 |
| 27 | Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: Results of a phase I trial | Journal of Allergy and Clinical Immunology | 2003 | 139 |
| 28 | Polyfunctional HCV‐specific T‐cell responses are associated with effective control of HCV replication | European Journal of Immunology | 2008 | 138 |
| 29 | Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study | Lancet Infectious Diseases, The | 2016 | 133 |
| 30 | A Malaria Vaccine That Elicits in Humans Antibodies Able to Kill Plasmodium falciparum | PLoS Medicine | 2005 | 124 |
| 31 | Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer | Nature Communications | 2018 | 122 |
| 32 | A synthetic malaria vaccine elicits a potent CD8+ and CD4+ T lymphocyte immune response in humans. Implications for vaccination strategies | European Journal of Immunology | 2001 | 121 |
| 33 | Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 118 |
| 34 | Determinants of HIV-1 reservoir size and long-term dynamics during suppressive ART | Nature Communications | 2019 | 112 |
| 35 | Phylogenetic Approach Reveals That Virus Genotype Largely Determines HIV Set-Point Viral Load | PLoS Pathogens | 2010 | 108 |
| 36 | Distinct Profiles of Cytotoxic Granules in Memory CD8 T Cells Correlate with Function, Differentiation Stage, and Antigen Exposure | Journal of Virology | 2009 | 104 |
| 37 | Type I interferonopathies in pediatric rheumatology | Pediatric Rheumatology | 2016 | 104 |
| 38 | pMHC affinity controls duration of CD8+ T cell–DC interactions and imprints timing of effector differentiation versus expansion | Journal of Experimental Medicine | 2016 | 101 |
| 39 | Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4×: a phase 2 randomised, double-blind, placebo-controlled trial | Lancet Infectious Diseases, The | 2014 | 100 |
| 40 | EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders | Allergy: European Journal of Allergy and Clinical Immunology | 2015 | 98 |
| 41 | Analysis of HIV-1– and CMV-specific memory CD4 T-cell responses during primary and chronic infection | Blood | 2002 | 97 |
| 42 | Oral Immunization of Mice with Lactic Acid Bacteria ProducingHelicobacter pyloriUrease B Subunit Partially Protects against Challenge withHelicobacter felis | Journal of Infectious Diseases | 2005 | 94 |
| 43 | Adverse reactions to biologic agents and their medical management | Nature Reviews Rheumatology | 2014 | 94 |
| 44 | Immune responses induced by lower airway mucosal immunisation with a human papillomavirus type 16 virus-like particle vaccine | Vaccine | 2005 | 93 |
| 45 | EV02: A Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone | Vaccine | 2008 | 89 |
| 46 | The adjuvant GLA-SE promotes human Tfh cell expansion and emergence of public TCRβ clonotypes | Journal of Experimental Medicine | 2019 | 87 |
| 47 | Cytomegalovirus (CMV)-Specific cellular immune responses | Human Immunology | 2004 | 86 |
| 48 | Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome | Journal of Clinical Immunology | 2019 | 85 |
| 49 | T cell homeostasis | Immunology and Cell Biology | 2008 | 83 |
| 50 | Impairment of JCV-specific T-cell response by corticotherapy | Neurology | 2012 | 82 |
