| # | Title | Journal | Year | Citations |
|---|
| 1 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | BMJ, The | 2021 | 26,066 |
| 2 | NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease | Alzheimer's and Dementia | 2018 | 5,861 |
| 3 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 4 | Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | Nature Cell Biology | 2008 | 4,285 |
| 5 | Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo | Nature | 2002 | 3,979 |
| 6 | The PRISMA 2020 statement: an updated guideline for reporting systematic reviews | Systematic Reviews | 2021 | 3,624 |
| 7 | Beta-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE | Science | 1999 | 3,619 |
| 8 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | International Journal of Surgery | 2021 | 3,487 |
| 9 | PRISMA 2020 explanation and elaboration: updated guidance and exemplars for reporting systematic reviews | BMJ, The | 2021 | 3,413 |
| 10 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 11 | Identification of a unique TGF-β–dependent molecular and functional signature in microglia | Nature Neuroscience | 2014 | 2,056 |
| 12 | Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression | Journal of Experimental Medicine | 2007 | 2,000 |
| 13 | Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators | Cell | 2006 | 1,948 |
| 14 | Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors | Science | 2017 | 1,846 |
| 15 | A? Oligomers ? a decade of discovery | Journal of Neurochemistry | 2007 | 1,795 |
| 16 | The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases | Immunity | 2017 | 1,741 |
| 17 | BoneJ: Free and extensible bone image analysis in ImageJ | Bone | 2010 | 1,695 |
| 18 | Natural oligomers of the amyloid-β protein specifically disrupt cognitive function | Nature Neuroscience | 2005 | 1,595 |
| 19 | Microglia Function in the Central Nervous System During Health and Neurodegeneration | Annual Review of Immunology | 2017 | 1,450 |
| 20 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | PLoS Medicine | 2021 | 1,340 |
| 21 | Insulin-degrading enzyme regulates the levels of insulin, amyloid -protein, and the -amyloid precursor protein intracellular domain in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,328 |
| 22 | Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS | Nature | 2013 | 1,249 |
| 23 | Amyloid fibrillogenesis: themes and variations | Current Opinion in Structural Biology | 2000 | 1,037 |
| 24 | Ubiquitination of a New Form of alpha -Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease | Science | 2001 | 1,033 |
| 25 | The PRISMA 2020 statement: An updated guideline for reporting systematic reviews | Journal of Clinical Epidemiology | 2021 | 995 |
| 26 | Epidemiology of Brain Metastases | Current Oncology Reports | 2012 | 975 |
| 27 | Individual Variability in Functional Connectivity Architecture of the Human Brain | Neuron | 2013 | 949 |
| 28 | Amyloid Deposition Is Associated with Impaired Default Network Function in Older Persons without Dementia | Neuron | 2009 | 899 |
| 29 | Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization | JAMA - Journal of the American Medical Association | 2021 | 829 |
| 30 | MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators | Molecular and Cellular Biology | 2008 | 828 |
| 31 | Tau positron emission tomographic imaging in aging and early Alzheimer disease | Annals of Neurology | 2016 | 778 |
| 32 | 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups | Annals of the Rheumatic Diseases | 2017 | 754 |
| 33 | GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment | Science | 2013 | 750 |
| 34 | Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US | JAMA Internal Medicine | 2020 | 711 |
| 35 | Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death | Neuron | 2003 | 665 |
| 36 | Dopamine covalently modifies and functionally inactivates parkin | Nature Medicine | 2005 | 658 |
| 37 | Parkinson's Disease: Genetics and Pathogenesis | Annual Review of Pathology: Mechanisms of Disease | 2011 | 654 |
| 38 | The Brain–Heart Connection | Circulation | 2007 | 646 |
| 39 | Alterations in Memory Networks in Mild Cognitive Impairment and Alzheimer's Disease: An Independent Component Analysis | Journal of Neuroscience | 2006 | 626 |
| 40 | Specific MicroRNAs Modulate Embryonic Stem Cell-Derived Neurogenesis | Stem Cells | 2006 | 611 |
| 41 | Microglial signatures and their role in health and disease | Nature Reviews Neuroscience | 2018 | 599 |
| 42 | The A4 Study: Stopping AD Before Symptoms Begin? | Science Translational Medicine | 2014 | 588 |
| 43 | The Host Shapes the Gut Microbiota via Fecal MicroRNA | Cell Host and Microbe | 2016 | 570 |
| 44 | Toward a Comprehensive Theory for Alzheimer's Disease. Hypothesis: Alzheimer's Disease Is Caused by the Cerebral Accumulation and Cytotoxicity of Amyloid β‐Protein | Annals of the New York Academy of Sciences | 2000 | 561 |
| 45 | Effects of secreted oligomers of amyloid β-protein on hippocampal synaptic plasticity: a potent role for trimers | Journal of Physiology | 2006 | 557 |
| 46 | The Preclinical Alzheimer Cognitive Composite | JAMA Neurology | 2014 | 548 |
| 47 | Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 546 |
| 48 | Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions | Neuro-Oncology | 2020 | 543 |
| 49 | The transcriptional landscape of age in human peripheral blood | Nature Communications | 2015 | 533 |
| 50 | Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup | Nature Communications | 2011 | 531 |
