| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Problems in echocardiographic volume determinations: Echocardiographic-angiographic correlations in the presence or absence of asynergy | American Journal of Cardiology | 1976 | 2,477 |
| 3 | Dissecting racial bias in an algorithm used to manage the health of populations | Science | 2019 | 2,111 |
| 4 | Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites | Science | 2009 | 1,806 |
| 5 | Effect of Reducing Interns' Work Hours on Serious Medical Errors in Intensive Care Units | New England Journal of Medicine | 2004 | 1,589 |
| 6 | TIMI Frame Count | Circulation | 1996 | 1,556 |
| 7 | Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 | Intensive Care Medicine | 2021 | 1,503 |
| 8 | An overview of randomized trials of rehabilitation with exercise after myocardial infarction. | Circulation | 1989 | 1,281 |
| 9 | Independent Association between Acute Renal Failure and Mortality following Cardiac Surgery 11Access the “Journal Club” discussion of this paper at http://www.elsevier.com/locate/ajmselect/22The VA Continuous Improvement in Cardiac Surgery Program was initially supported by the Health Services Research and Development Service, Veterans Health Administration, and funded through VA Patient Care Services. | American Journal of Medicine | 1998 | 1,252 |
| 10 | Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons | Neuron | 1999 | 1,200 |
| 11 | The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart | Nature | 1987 | 1,173 |
| 12 | Guidelines for investigating causality of sequence variants in human disease | Nature | 2014 | 1,130 |
| 13 | Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes | Nature Genetics | 2018 | 1,124 |
| 14 | Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program | Nature | 2021 | 1,069 |
| 15 | Characterisation of COPD heterogeneity in the ECLIPSE cohort | Respiratory Research | 2010 | 952 |
| 16 | Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons | Journal of Neuroscience | 1999 | 926 |
| 17 | Myocardial infarction accelerates atherosclerosis | Nature | 2012 | 874 |
| 18 | Local proliferation dominates lesional macrophage accumulation in atherosclerosis | Nature Medicine | 2013 | 855 |
| 19 | Common genetic variants influence human subcortical brain structures | Nature | 2015 | 772 |
| 20 | C-Reactive Protein Is a Potent Predictor of Mortality Independently of and in Combination With Troponin T in Acute Coronary Syndromes: A TIMI 11A Substudy | Journal of the American College of Cardiology | 1998 | 718 |
| 21 | Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US | JAMA Internal Medicine | 2020 | 711 |
| 22 | Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses | Immunity | 2014 | 702 |
| 23 | Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976 | BMJ: British Medical Journal | 1997 | 697 |
| 24 | Surgery and Global Health: A View from Beyond the OR | World Journal of Surgery | 2008 | 662 |
| 25 | Engineering Stem Cell Organoids | Cell Stem Cell | 2016 | 654 |
| 26 | ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible | Science | 2013 | 624 |
| 27 | Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption | Science Translational Medicine | 2012 | 619 |
| 28 | Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection | Nature | 2011 | 601 |
| 29 | Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 | Cell | 2020 | 599 |
| 30 | Implications of Small Reductions in Diastolic Blood Pressure for Primary Prevention | Archives of Internal Medicine | 1995 | 582 |
| 31 | Chronic variable stress activates hematopoietic stem cells | Nature Medicine | 2014 | 565 |
| 32 | Acute Pancreatitis: Bench to the Bedside | Gastroenterology | 2007 | 550 |
| 33 | The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemia | Nature Reviews Cancer | 2017 | 542 |
| 34 | COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets | Nature | 2021 | 537 |
| 35 | Assessment of Resistance Mechanisms and Clinical Implications in Patients WithEGFRT790M–Positive Lung Cancer and Acquired Resistance to Osimertinib | JAMA Oncology | 2018 | 522 |
| 36 | Validation of Patient Reports, Automated Pharmacy Records, and Pill Counts With Electronic Monitoring of Adherence to Antihypertensive Therapy | Medical Care | 1999 | 515 |
| 37 | Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis | Lancet Public Health, The | 2018 | 506 |
| 38 | The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 | Cell | 2013 | 505 |
| 39 | Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men | Diabetes | 2010 | 477 |
| 40 | Inflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury | American Journal of Respiratory and Critical Care Medicine | 2012 | 469 |
| 41 | Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny | Nature Methods | 2014 | 466 |
| 42 | The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation | Nature | 2017 | 460 |
| 43 | Myonecrosis After Revascularization Procedures | Journal of the American College of Cardiology | 1998 | 459 |
| 44 | Presentation of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop | Journal of Clinical Endocrinology and Metabolism | 2009 | 451 |
| 45 | Four-Parameter Model of the Sigmoidal Relationship between Parathyroid Hormone Release and Extracellular Calcium Concentration in Normal and Abnormal Parathyroid Tissue* | Journal of Clinical Endocrinology and Metabolism | 1983 | 437 |
| 46 | Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis | Journal of Experimental Medicine | 2012 | 435 |
| 47 | Palliative Care in Heart Failure | Journal of the American College of Cardiology | 2017 | 425 |
| 48 | Effect of mobile phone intervention for diabetes on glycaemic control: a meta-analysis | Diabetic Medicine | 2011 | 423 |
| 49 | Homeostatic proliferation is a barrier to transplantation tolerance | Nature Medicine | 2004 | 388 |
| 50 | Trends in Outpatient Care Delivery and Telemedicine During the COVID-19 Pandemic in the US | JAMA Internal Medicine | 2021 | 388 |
