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Top Articles

#TitleJournalYearCitations
1NF-kappaB Signaling Pathways in Neurological Inflammation: A Mini ReviewFrontiers in Molecular Neuroscience2015616
2Electrospun collagen/chitosan nanofibrous membrane as wound dressingColloids and Surfaces A: Physicochemical and Engineering Aspects2008438
3Oxidative stress caused by mitochondrial calcium overloadAnnals of the New York Academy of Sciences2010411
4Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideasCellular and Molecular Life Sciences2017369
5Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseasesBiochemical Pharmacology2012346
6Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytesJournal of Pineal Research2004240
7Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1Journal of Cellular Physiology2006234
8Electrospun PLGA/collagen nanofibrous membrane as early-stage wound dressingJournal of Membrane Science2010220
9Melatonin protects against common deletion of mitochondrial DNA‐augmented mitochondrial oxidative stress and apoptosisJournal of Pineal Research2007217
10The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer ChemotherapyMolecular Pharmaceutics2011199
11Magnetically targeted thrombolysis with recombinant tissue plasminogen activator bound to polyacrylic acid-coated nanoparticlesBiomaterials2009163
12Characterization of chitosan magnetic nanoparticles for in situ delivery of tissue plasminogen activatorCarbohydrate Polymers2011148
13Visualization of melatonin’s multiple mitochondrial levels of protection against mitochondrial Ca2+‐mediated permeability transition and beyond in rat brain astrocytesJournal of Pineal Research2010145
14Involvement of p42/p44 MAPK, p38 MAPK, JNK and nuclear factor-kappa B in interleukin-1beta-induced matrix metalloproteinase-9 expression in rat brain astrocytesJournal of Neurochemistry2004132
15Interleukin-1β induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-κB signaling pathways in human tracheal smooth muscle cellsJournal of Cellular Physiology2007121
16Sustainable release of vancomycin, gentamicin and lidocaine from novel electrospun sandwich-structured PLGA/collagen nanofibrous membranesInternational Journal of Pharmaceutics2012108
17Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activationFree Radical Biology and Medicine2010100
18Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening AssayAntimicrobial Agents and Chemotherapy2011100
19Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cellsCell Communication and Signaling201297
20Cooperation of TLR2 with MyD88, PI3K, and Rac1 in Lipoteichoic Acid–Induced cPLA2/COX-2–Dependent Airway Inflammatory ResponsesAmerican Journal of Pathology201087
21P2Y2 receptor-mediated proliferation of C6 glioma cells via activation of Ras/Raf/MEK/MAPK pathwayBritish Journal of Pharmacology200085
22Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytesJournal of Neuroinflammation201284
23Enterovirus 71 induces COX-2 expression via MAPKs, NF-κB, and AP-1 in SK–N–SH cells: Role of PGE2 in viral replicationCellular Signalling201080
24Cigarette smoke particle-phase extract induces HO-1 expression in human tracheal smooth muscle cells: role of the c-Src/NADPH oxidase/MAPK/Nrf2 signaling pathwayFree Radical Biology and Medicine201080
25Melatonin prevents hypertension and increased asymmetric dimethylarginine in young spontaneous hypertensive ratsJournal of Pineal Research201080
26Melatonin Mitigates Mitochondrial Meltdown: Interactions with SIRT3International Journal of Molecular Sciences201880
27Riluzole and Prognostic Factors in Amyotrophic Lateral Sclerosis Long-term and Short-term Survival: A Population-Based Study of 1149 Cases in TaiwanJournal of Epidemiology201377
28Critical role of mitochondrial reactive oxygen species formation in visible laser irradiation-induced apoptosis in rat brain astrocytes (RBA-1)Journal of Biomedical Science200275
29Resveratrol inhibits BK-induced COX-2 transcription by suppressing acetylation of AP-1 and NF-κB in human rheumatoid arthritis synovial fibroblastsBiochemical Pharmacology201775
30Mitogenic effect of oxidized low-density lipoprotein on vascular smooth muscle cells mediated by activation of Ras/Raf/MEK/MAPK pathwayBritish Journal of Pharmacology200172
31Enterovirus 71 induces integrin β1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: Role of HO-1/CO in viral replicationJournal of Cellular Physiology201172
32Protective effects of (−)-epigallocatechin-3-gallate against TNF-α-induced lung inflammation via ROS-dependent ICAM-1 inhibitionJournal of Nutritional Biochemistry201372
33Intracellular signalings underlying bradykinin-induced matrix metalloproteinase-9 expression in rat brain astrocyte-1Cellular Signalling200471
34BK-induced COX-2 expression via PKC-δ-dependent activation of p42/p44 MAPK and NF-κB in astrocytesCellular Signalling200770
35Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cellsBiochemical Pharmacology201370
36Interleukin-1β-induced cyclooxygenase-2 expression is mediated through activation of p42/44 and p38 MAPKS, and NF-κB pathways in canine tracheal smooth muscle cellsCellular Signalling200269
37Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonismExperimental Neurology201569
38Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cellsJournal of Cellular Physiology200667
39IL‐1β induces MMP‐9 expression via a Ca2+‐dependent CaMKII/JNK/c‐JUN cascade in rat brain astrocytesGlia200967
40Involvement of p42/p44 MAPK, JNK, and NF-?B in IL-1?-induced ICAM-1 expression in human pulmonary epithelial cellsJournal of Cellular Physiology200565
41TNF-α induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-κB activation in osteoblast-like MC3T3-E1 cellsJournal of Biomedical Science201465
42Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophagesJournal of Clinical Investigation201764
43The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or MedicineBiomedical Journal201864
44Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: Involvement of Src/EGFR/PI3-K/Akt pathwayToxicology and Applied Pharmacology200863
45Induction of heme oxygenase-1 attenuates lipopolysaccharide-induced cyclooxygenase-2 expression in mouse brain endothelial cellsJournal of Neuroinflammation201063
46Reactive Oxygen Species-Dependent c-Fos/Activator Protein 1 Induction Upregulates Heme Oxygenase-1 Expression by Bradykinin in Brain AstrocytesAntioxidants and Redox Signaling201063
47Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-κB pathway in human pulmonary alveolar epithelial cellsAmerican Journal of Physiology - Lung Cellular and Molecular Physiology201663
48Mitochondrial Reactive Oxygen Species Generation and Calcium Increase Induced by Visible Light in AstrocytesAnnals of the New York Academy of Sciences200461
49PKC-δ/c-Src-mediated EGF receptor transactivation regulates thrombin-induced COX-2 expression and PGE2 production in rat vascular smooth muscle cellsBiochimica Et Biophysica Acta - Molecular Cell Research200861
50NADPH oxidase 2-derived reactive oxygen species signal contributes to bradykinin-induced matrix metalloproteinase-9 expression and cell migration in brain astrocytesCell Communication and Signaling201261