| # | Title | Journal | Year | Citations |
|---|
| 1 | Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior | Cell | 1998 | 4,993 |
| 2 | The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor | Cell | 1997 | 3,353 |
| 3 | Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy | Cell | 2005 | 3,204 |
| 4 | Narcolepsy in orexin Knockout Mice | Cell | 1999 | 2,981 |
| 5 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,292 |
| 6 | SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver | Journal of Clinical Investigation | 2002 | 2,177 |
| 7 | THE SYNAPTIC VESICLE CYCLE | Annual Review of Neuroscience | 2004 | 2,090 |
| 8 | The synaptic vesicle cycle: a cascade of protein–protein interactions | Nature | 1995 | 1,951 |
| 9 | The Enzymes, Regulation, and Genetics of Bile Acid Synthesis | Annual Review of Biochemistry | 2003 | 1,610 |
| 10 | An oxysterol signalling pathway mediated by the nuclear receptor LXRα | Nature | 1996 | 1,597 |
| 11 | Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis | Cell Metabolism | 2005 | 1,514 |
| 12 | Protein Sensors for Membrane Sterols | Cell | 2006 | 1,405 |
| 13 | Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. | Journal of Clinical Investigation | 1993 | 1,383 |
| 14 | Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse | Cell | 1994 | 1,377 |
| 15 | A comprehensive classification system for lipids | Journal of Lipid Research | 2005 | 1,348 |
| 16 | Membrane Fusion | Cell | 2003 | 1,336 |
| 17 | Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors | Molecular Cell | 2000 | 1,321 |
| 18 | Regulated Intramembrane Proteolysis | Cell | 2000 | 1,275 |
| 19 | Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 | Nature Genetics | 2005 | 1,246 |
| 20 | Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 1,233 |
| 21 | A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 1,195 |
| 22 | Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2 | Cell | 1999 | 1,194 |
| 23 | Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion | Science | 2000 | 1,158 |
| 24 | Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. | Genes and Development | 1997 | 1,150 |
| 25 | Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone | Cell | 2008 | 1,058 |
| 26 | The LDL Receptor | Arteriosclerosis, Thrombosis, and Vascular Biology | 2009 | 1,050 |
| 27 | Molecular genetics of the LDL receptor gene in familial hypercholesterolemia | Human Mutation | 1992 | 1,045 |
| 28 | Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme | Journal of Biological Chemistry | 1989 | 956 |
| 29 | SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis | Cell | 1994 | 954 |
| 30 | Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy | Nature | 1999 | 941 |
| 31 | α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration | Cell | 2005 | 895 |
| 32 | Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 893 |
| 33 | Crucial Step in Cholesterol Homeostasis | Cell | 2002 | 861 |
| 34 | Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation | Neuron | 1999 | 846 |
| 35 | SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene | Cell | 1993 | 841 |
| 36 | Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice | Neuron | 2003 | 833 |
| 37 | Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides | Cell | 1990 | 827 |
| 38 | A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins | Cell | 2015 | 827 |
| 39 | Selective versus Total Insulin Resistance: A Pathogenic Paradox | Cell Metabolism | 2008 | 810 |
| 40 | Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area | Journal of Comparative Neurology | 1998 | 783 |
| 41 | Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2020 | 776 |
| 42 | Bile acid biosynthesis | Biochemistry | 1992 | 743 |
| 43 | Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice | Gastroenterology | 2013 | 740 |
| 44 | Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. | Journal of Clinical Investigation | 1996 | 739 |
| 45 | Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice | Molecular Cell | 2000 | 737 |
| 46 | Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. | Journal of Clinical Investigation | 1997 | 722 |
| 47 | Neuroligins Determine Synapse Maturation and Function | Neuron | 2006 | 717 |
| 48 | Essential functions of synapsins I and II in synaptic vesicle regulation | Nature | 1995 | 708 |
| 49 | Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy | Genes and Development | 1998 | 695 |
| 50 | Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 685 |
