| # | Title | Journal | Year | Citations |
|---|
| 1 | Autophagy in immunity and inflammation | Nature | 2011 | 2,901 |
| 2 | Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity | Journal of Immunology | 2005 | 1,438 |
| 3 | Autophagic cell death: the story of a misnomer | Nature Reviews Molecular Cell Biology | 2008 | 1,291 |
| 4 | Viruses and interferon: a fight for supremacy | Nature Reviews Immunology | 2002 | 1,078 |
| 5 | Interactions between the microbiota and pathogenic bacteria in the gut | Nature | 2016 | 974 |
| 6 | Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells | Nature | 1988 | 887 |
| 7 | Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 859 |
| 8 | Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I | Journal of Virology | 2005 | 830 |
| 9 | Bacteria-host communication: The language of hormones | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 776 |
| 10 | Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity | Nature | 2014 | 773 |
| 11 | The Pangenome Structure ofEscherichia coli: Comparative Genomic Analysis ofE. coliCommensal and Pathogenic Isolates | Journal of Bacteriology | 2008 | 763 |
| 12 | Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease | Science | 2003 | 762 |
| 13 | The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention | Cell | 2017 | 756 |
| 14 | Bcl-2 family members: Dual regulators of apoptosis and autophagy | Autophagy | 2008 | 741 |
| 15 | HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein | Cell Host and Microbe | 2007 | 733 |
| 16 | Shared and Distinct Functions of Type I and Type III Interferons | Immunity | 2019 | 699 |
| 17 | Identification of a RING protein that can interact in vivo with the BRCA1 gene product | Nature Genetics | 1996 | 683 |
| 18 | Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2 | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 667 |
| 19 | Inter-kingdom signalling: communication between bacteria and their hosts | Nature Reviews Microbiology | 2008 | 624 |
| 20 | Interferon-Stimulated Genes: What Do They All Do? | Annual Review of Virology | 2019 | 622 |
| 21 | To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate | Cell | 2014 | 606 |
| 22 | Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella | Cell Host and Microbe | 2016 | 600 |
| 23 | Evasion of intracellular host defence by hepatitis C virus | Nature | 2005 | 582 |
| 24 | Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor | Cell | 1992 | 565 |
| 25 | Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza A Virus | Journal of Virology | 2007 | 529 |
| 26 | Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis | Science | 2011 | 526 |
| 27 | The QseC sensor kinase: A bacterial adrenergic receptor | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 523 |
| 28 | Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 506 |
| 29 | Abnormally short serum half-lives of IgG in β2-microglobulin-deficient mice | European Journal of Immunology | 1996 | 449 |
| 30 | The Lyme disease agent exploits a tick protein to infect the mammalian host | Nature | 2005 | 441 |
| 31 | STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease | Cell Host and Microbe | 2015 | 424 |
| 32 | Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages | Cell Host and Microbe | 2012 | 416 |
| 33 | Non‐Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co‐Delivery of Cas9 mRNA and sgRNA | Angewandte Chemie - International Edition | 2017 | 411 |
| 34 | Fucose sensing regulates bacterial intestinal colonization | Nature | 2012 | 410 |
| 35 | Ebola Virus VP35 Protein Binds Double-Stranded RNA and Inhibits Alpha/Beta Interferon Production Induced by RIG-I Signaling | Journal of Virology | 2006 | 405 |
| 36 | Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 394 |
| 37 | Precision editing of the gut microbiota ameliorates colitis | Nature | 2018 | 377 |
| 38 | Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells. | Journal of Experimental Medicine | 1988 | 363 |
| 39 | Bcl-2 family members: dual regulators of apoptosis and autophagy | Autophagy | 2008 | 350 |
| 40 | TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi | Cell | 2004 | 348 |
| 41 | RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival | Cell | 2006 | 344 |
| 42 | The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression | Journal of Biological Chemistry | 1998 | 343 |
| 43 | Quorum sensing: the many languages of bacteria | FEMS Microbiology Letters | 2006 | 333 |
| 44 | Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis | Cell Host and Microbe | 2015 | 327 |
| 45 | Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes Mellitus | New England Journal of Medicine | 1990 | 326 |
| 46 | Distinct Poly(I-C) and Virus-activated Signaling Pathways Leading to Interferon-β Production in Hepatocytes | Journal of Biological Chemistry | 2005 | 322 |
| 47 | Redesigning nature's poisons to create anti-tumor reagents | Science | 1987 | 315 |
| 48 | DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 313 |
| 49 | Activation and regulation of Toll-like receptors 2 and 1 in human leprosy | Nature Medicine | 2003 | 311 |
| 50 | Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 309 |
