| # | Title | Journal | Year | Citations |
|---|
| 1 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade | Cell | 1997 | 6,625 |
| 2 | Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors | Cell | 1998 | 3,278 |
| 3 | Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition | Cell | 2000 | 3,149 |
| 4 | Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 | Cell | 1997 | 2,941 |
| 5 | Biochemical Pathways of Caspase Activation During Apoptosis | Annual Review of Cell and Developmental Biology | 1999 | 2,313 |
| 6 | A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF | Science | 2001 | 2,312 |
| 7 | Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase | Cell | 2012 | 2,056 |
| 8 | Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals | Cell | 2007 | 2,026 |
| 9 | Phase transitions in the assembly of multivalent signalling proteins | Nature | 2012 | 1,938 |
| 10 | Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α | Cell | 2009 | 1,882 |
| 11 | The expanding role of mitochondria in apoptosis | Genes and Development | 2001 | 1,827 |
| 12 | An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9 | Journal of Biological Chemistry | 1999 | 1,789 |
| 13 | Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA | Science | 2013 | 1,778 |
| 14 | DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis | Cell | 1997 | 1,758 |
| 15 | Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels | Cell | 2012 | 1,725 |
| 16 | Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain | Cell | 2000 | 1,707 |
| 17 | Accumulation of Dietary Cholesterol in Sitosterolemia Caused by Mutations in Adjacent ABC Transporters | Science | 2000 | 1,412 |
| 18 | Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey | Molecular Cell | 2006 | 1,372 |
| 19 | Structural Mechanism for Statin Inhibition of HMG-CoA Reductase | Science | 2001 | 1,316 |
| 20 | Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21 | Cell Metabolism | 2007 | 1,306 |
| 21 | Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer | Nature Chemical Biology | 2009 | 1,259 |
| 22 | The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins | Nature | 1988 | 1,229 |
| 23 | Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor | Nature | 2010 | 1,192 |
| 24 | Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation | Cell | 1994 | 1,183 |
| 25 | The leucine-rich repeat: a versatile binding motif | Trends in Biochemical Sciences | 1994 | 1,172 |
| 26 | TNF-α Induces Two Distinct Caspase-8 Activation Pathways | Cell | 2008 | 1,169 |
| 27 | Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion | Science | 2000 | 1,158 |
| 28 | The structure of the G protein heterotrimer Giα1β1γ2 | Cell | 1995 | 1,125 |
| 29 | RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway | Cell | 2009 | 1,026 |
| 30 | Crystal Structure of the Cytochrome bc1Complex from Bovine Heart Mitochondria | Science | 1997 | 996 |
| 31 | White Fat Progenitor Cells Reside in the Adipose Vasculature | Science | 2008 | 983 |
| 32 | Crystal Structure of Hemoprotein Domain of P450BM-3, a Prototype for Microsomal P450's | Science | 1993 | 943 |
| 33 | Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy | Nature | 1999 | 941 |
| 34 | A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice | Science | 2007 | 932 |
| 35 | Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING | Molecular Cell | 2013 | 819 |
| 36 | Structural basis of IAP recognition by Smac/DIABLO | Nature | 2000 | 806 |
| 37 | The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways | Cell | 2012 | 799 |
| 38 | Regulation of cellular iron metabolism | Biochemical Journal | 2011 | 795 |
| 39 | BAP1 loss defines a new class of renal cell carcinoma | Nature Genetics | 2012 | 791 |
| 40 | Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure | Science | 1989 | 790 |
| 41 | Logic of the Yeast Metabolic Cycle: Temporal Compartmentalization of Cellular Processes | Science | 2005 | 784 |
| 42 | Structural and biochemical basis of apoptotic activation by Smac/DIABLO | Nature | 2000 | 783 |
| 43 | Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis | Cell | 1997 | 772 |
| 44 | A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus | Cell | 1993 | 759 |
| 45 | Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis | Cell | 2005 | 756 |
| 46 | The U6 snRNA m 6 A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention | Cell | 2017 | 756 |
| 47 | C2-domains, Structure and Function of a Universal Ca2+-binding Domain | Journal of Biological Chemistry | 1998 | 755 |
| 48 | Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice | Molecular Cell | 2000 | 737 |
| 49 | Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS | Science | 1997 | 736 |
| 50 | Influence of Metabolism on Epigenetics and Disease | Cell | 2013 | 729 |
