| # | Title | Journal | Year | Citations |
|---|
| 1 | Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions* | Endocrine Reviews | 2001 | 3,352 |
| 2 | Identification of a Nuclear Receptor for Bile Acids | Science | 1999 | 2,377 |
| 3 | ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF | Cell | 1991 | 1,862 |
| 4 | Nuclear Receptors and Lipid Physiology: Opening the X-Files | Science | 2001 | 1,848 |
| 5 | An oxysterol signalling pathway mediated by the nuclear receptor LXRα | Nature | 1996 | 1,597 |
| 6 | How MAP Kinases Are Regulated | Journal of Biological Chemistry | 1995 | 1,588 |
| 7 | Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ | Genes and Development | 2000 | 1,463 |
| 8 | Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα | Cell | 1998 | 1,322 |
| 9 | Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors | Molecular Cell | 2000 | 1,321 |
| 10 | Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21 | Cell Metabolism | 2007 | 1,306 |
| 11 | Evolutionarily Conserved Pathways of Energetic Connectivity in Protein Families | Science | 1999 | 1,210 |
| 12 | Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers | Science | 2000 | 1,206 |
| 13 | Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases | Cell | 2012 | 1,162 |
| 14 | Reciprocal regulation of inflammation and lipid metabolism by liver X receptors | Nature Medicine | 2003 | 1,088 |
| 15 | GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins | Annual Review of Biochemistry | 2000 | 1,066 |
| 16 | Vitamin D Receptor As an Intestinal Bile Acid Sensor | Science | 2002 | 1,053 |
| 17 | G proteins | Trends in Biochemical Sciences | 1992 | 984 |
| 18 | Cellular Heterogeneity: Do Differences Make a Difference? | Cell | 2010 | 968 |
| 19 | ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity | Cell | 1993 | 939 |
| 20 | Nuclear Receptors, RXR, and the Big Bang | Cell | 2014 | 927 |
| 21 | Enhancement of oxidative and drought tolerance in Arabidopsis by overaccumulation of antioxidant flavonoids | Plant Journal | 2014 | 911 |
| 22 | Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq | Science | 1991 | 904 |
| 23 | Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ | Proceedings of the National Academy of Sciences of the United States of America | 1999 | 880 |
| 24 | Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network | Cell | 2006 | 878 |
| 25 | p21ras is modified by a farnesyl isoprenoid. | Proceedings of the National Academy of Sciences of the United States of America | 1989 | 855 |
| 26 | Nuclear Receptor Expression Links the Circadian Clock to Metabolism | Cell | 2006 | 852 |
| 27 | p115 RhoGEF, a GTPase Activating Protein for G12 and G13 | Science | 1998 | 839 |
| 28 | Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING | Molecular Cell | 2013 | 819 |
| 29 | MAP Kinases | Chemical Reviews | 2001 | 812 |
| 30 | Complexity and Diversity of Mammalian Adenylyl Cyclases | Annual Review of Pharmacology and Toxicology | 1996 | 804 |
| 31 | Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure | Science | 1989 | 790 |
| 32 | Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis | Cell | 1997 | 772 |
| 33 | GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits | Cell | 1996 | 733 |
| 34 | Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins | Cell | 2016 | 723 |
| 35 | Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors α and β | Journal of Biological Chemistry | 2002 | 708 |
| 36 | An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control | Science | 1990 | 700 |
| 37 | A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals | Nature Materials | 2014 | 695 |
| 38 | Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth | Physiological Reviews | 1993 | 666 |
| 39 | The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis | Annual Review of Cell and Developmental Biology | 2000 | 654 |
| 40 | A STING-activating nanovaccine for cancer immunotherapy | Nature Nanotechnology | 2017 | 649 |
| 41 | Protein Sectors: Evolutionary Units of Three-Dimensional Structure | Cell | 2009 | 642 |
| 42 | A conformational switch in syntaxin during exocytosis: role of munc18 | EMBO Journal | 1999 | 622 |
| 43 | Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution | Nature | 1994 | 619 |
| 44 | FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 605 |
| 45 | Mammalian Membrane-bound Adenylyl Cyclases | Journal of Biological Chemistry | 1995 | 592 |
| 46 | Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. | Journal of Biological Chemistry | 1990 | 566 |
| 47 | G protein involvement in receptor-effector coupling. | Journal of Biological Chemistry | 1988 | 554 |
| 48 | The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control | Developmental Cell | 2008 | 547 |
| 49 | Drosophila OBP LUSH Is Required for Activity of Pheromone-Sensitive Neurons | Neuron | 2005 | 544 |
| 50 | Vascular Targeting Agents as Cancer Therapeutics | Clinical Cancer Research | 2004 | 542 |
