| # | Title | Journal | Year | Citations |
|---|
| 1 | Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior | Cell | 1998 | 4,993 |
| 2 | Narcolepsy in orexin Knockout Mice | Cell | 1999 | 2,981 |
| 3 | Lymphocyte Homing and Homeostasis | Science | 1996 | 2,699 |
| 4 | A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy | Cell | 1998 | 2,388 |
| 5 | Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres | Nature | 2002 | 2,232 |
| 6 | Transient Regenerative Potential of the Neonatal Mouse Heart | Science | 2011 | 2,117 |
| 7 | The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration | Nature Biotechnology | 2007 | 1,955 |
| 8 | A restricted cell population propagates glioblastoma growth after chemotherapy | Nature | 2012 | 1,932 |
| 9 | Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis | Cell Metabolism | 2005 | 1,514 |
| 10 | The history and future of targeting cyclin-dependent kinases in cancer therapy | Nature Reviews Drug Discovery | 2015 | 1,316 |
| 11 | Reeler/Disabled-like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL Receptor and ApoE Receptor 2 | Cell | 1999 | 1,194 |
| 12 | Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice | Cell | 1994 | 994 |
| 13 | Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration | Acta Neuropathologica | 2007 | 978 |
| 14 | Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons | Cell | 1994 | 926 |
| 15 | Lactate Metabolism in Human Lung Tumors | Cell | 2017 | 899 |
| 16 | Renal-Limited “Lupus-Like” Nephritis: How Much of a Lupus | Case Reports in Nephrology and Dialysis | 2017 | 890 |
| 17 | Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets | Nature Communications | 2015 | 879 |
| 18 | Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion | Nature | 2016 | 843 |
| 19 | DNA damage and repair | Nature | 2003 | 842 |
| 20 | Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies | Nature Medicine | 2021 | 838 |
| 21 | BAP1 loss defines a new class of renal cell carcinoma | Nature Genetics | 2012 | 791 |
| 22 | Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry | Blood | 1995 | 784 |
| 23 | Radiotherapy and immunotherapy: a beneficial liaison? | Nature Reviews Clinical Oncology | 2017 | 760 |
| 24 | 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas | Nature Medicine | 2012 | 711 |
| 25 | How nucleotide excision repair protects against cancer | Nature Reviews Cancer | 2001 | 661 |
| 26 | Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21 | Journal of Biological Chemistry | 2007 | 654 |
| 27 | A STING-activating nanovaccine for cancer immunotherapy | Nature Nanotechnology | 2017 | 649 |
| 28 | Smad3 Mutant Mice Develop Metastatic Colorectal Cancer | Cell | 1998 | 631 |
| 29 | Physiological and Molecular Mechanisms of Lymphocyte Homing | Annual Review of Immunology | 1992 | 627 |
| 30 | Race and Gender Differences in C-Reactive Protein Levels | Journal of the American College of Cardiology | 2005 | 618 |
| 31 | Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model | Cancer Cell | 2009 | 612 |
| 32 | ViPR: an open bioinformatics database and analysis resource for virology research | Nucleic Acids Research | 2012 | 610 |
| 33 | Distinct Narcolepsy Syndromes in Orexin Receptor-2 and Orexin Null Mice | Neuron | 2003 | 603 |
| 34 | Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases | Cell | 2014 | 594 |
| 35 | DNA Repair and Mutagenesis | Cell | 2005 | 591 |
| 36 | The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140 | Cell | 1991 | 572 |
| 37 | TDP‐43 A315T mutation in familial motor neuron disease | Annals of Neurology | 2008 | 572 |
| 38 | Neurofibromas in NF1: Schwann Cell Origin and Role of Tumor Environment | Science | 2002 | 568 |
| 39 | A Tlr7 translocation accelerates systemic autoimmunity in murine lupus | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 567 |
| 40 | Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo | Nature | 2002 | 563 |
| 41 | Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21 | Cancer Cell | 2010 | 551 |
| 42 | Adult haematopoietic stem cell niches | Nature Reviews Immunology | 2017 | 528 |
| 43 | Acetate Dependence of Tumors | Cell | 2014 | 524 |
| 44 | βKlotho is required for metabolic activity of fibroblast growth factor 21 | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 516 |
| 45 | Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site | Science | 1997 | 514 |
| 46 | Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule | FASEB Journal | 2010 | 511 |
| 47 | Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. | Journal of Clinical Investigation | 1997 | 508 |
| 48 | Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project | Nature Biotechnology | 2008 | 506 |
| 49 | Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma | Cancer Cell | 2005 | 481 |
| 50 | Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions | Nature Genetics | 2010 | 479 |
