| # | Title | Journal | Year | Citations |
|---|
| 1 | In vitro selection of RNA molecules that bind specific ligands | Nature | 1990 | 8,658 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans | Nature | 2000 | 4,315 |
| 4 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis | Nature Protocols | 2007 | 4,224 |
| 5 | Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans | Cell | 1993 | 3,657 |
| 6 | Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation | Physiological Reviews | 2001 | 3,019 |
| 7 | PPAR-γ agonists inhibit production of monocyte inflammatory cytokines | Nature | 1998 | 2,818 |
| 8 | A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA | Science | 2001 | 2,450 |
| 9 | MAP kinase signalling cascade in Arabidopsis innate immunity | Nature | 2002 | 2,407 |
| 10 | Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA | Nature | 2000 | 2,167 |
| 11 | daf-2, an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans | Science | 1997 | 2,072 |
| 12 | SUGAR SENSING AND SIGNALING IN PLANTS: Conserved and Novel Mechanisms | Annual Review of Plant Biology | 2006 | 1,919 |
| 13 | The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans | Nature | 1997 | 1,812 |
| 14 | Genes and Mechanisms Related to RNA Interference Regulate Expression of the Small Temporal RNAs that Control C. elegans Developmental Timing | Cell | 2001 | 1,731 |
| 15 | Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action | Cell | 2002 | 1,612 |
| 16 | Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2 | Cell | 1993 | 1,560 |
| 17 | Synthesizing life | Nature | 2001 | 1,537 |
| 18 | Polycomb Proteins Targeted by a Short Repeat RNA to the Mouse X Chromosome | Science | 2008 | 1,477 |
| 19 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 20 | Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 1,412 |
| 21 | The Arabidopsis NPR1 Gene That Controls Systemic Acquired Resistance Encodes a Novel Protein Containing Ankyrin Repeats | Cell | 1997 | 1,408 |
| 22 | Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 | Nature | 1993 | 1,407 |
| 23 | Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans | Nature | 2009 | 1,405 |
| 24 | Plants have a sensitive perception system for the most conserved domain of bacterial flagellin | Plant Journal | 1999 | 1,376 |
| 25 | Cooperation between Complexes that Regulate Chromatin Structure and Transcription | Cell | 2002 | 1,370 |
| 26 | Engineered GFP as a vital reporter in plants | Current Biology | 1996 | 1,322 |
| 27 | A central integrator of transcription networks in plant stress and energy signalling | Nature | 2007 | 1,270 |
| 28 | Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor | Science | 2003 | 1,259 |
| 29 | The microglial sensome revealed by direct RNA sequencing | Nature Neuroscience | 2013 | 1,244 |
| 30 | Common virulence factors for bacterial pathogenicity in plants and animals | Science | 1995 | 1,218 |
| 31 | Mechanisms of Polycomb gene silencing: knowns and unknowns | Nature Reviews Molecular Cell Biology | 2009 | 1,185 |
| 32 | Epigenetic Regulation by Long Noncoding RNAs | Science | 2012 | 1,159 |
| 33 | In Vitro Selection of Functional Nucleic Acids | Annual Review of Biochemistry | 1999 | 1,157 |
| 34 | A DNA Aptamer That Binds Adenosine and ATP | Biochemistry | 1995 | 1,147 |
| 35 | In vitro reconstitution of an abscisic acid signalling pathway | Nature | 2009 | 1,113 |
| 36 | A simple phase-extraction assay for chloramphenicol acyltransferase activity | Gene | 1988 | 1,069 |
| 37 | ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION | Annual Review of Biochemistry | 1998 | 1,061 |
| 38 | Glucosinolate Metabolites Required for an Arabidopsis Innate Immune Response | Science | 2009 | 1,037 |
| 39 | Role of the Arabidopsis Glucose Sensor HXK1 in Nutrient, Light, and Hormonal Signaling | Science | 2003 | 1,023 |
| 40 | Directed evolution of APEX2 for electron microscopy and proximity labeling | Nature Methods | 2015 | 1,014 |
| 41 | RNA-peptide fusions for the in vitro selection of peptides and proteins | Proceedings of the National Academy of Sciences of the United States of America | 1997 | 987 |
| 42 | Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells | Science | 1990 | 985 |
| 43 | Sugar Sensing and Signaling in Plants | Plant Cell | 2002 | 946 |
| 44 | Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes | Nature | 2003 | 940 |
| 45 | The endoplasmic reticulum: structure, function and response to cellular signaling | Cellular and Molecular Life Sciences | 2016 | 940 |
| 46 | An ordered, nonredundant library of Pseudomonas aeruginosa strain PA14 transposon insertion mutants | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 918 |
| 47 | Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq | Molecular Cell | 2010 | 914 |
| 48 | A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity | Nature Genetics | 2003 | 900 |
| 49 | Membrane Compartmentation Is Required for Efficient T Cell Activation | Immunity | 1998 | 865 |
| 50 | Tumor Induction of VEGF Promoter Activity in Stromal Cells | Cell | 1998 | 861 |
