| # | Title | Journal | Year | Citations |
|---|
| 1 | Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma | Acta Neuropathologica | 2011 | 914 |
| 2 | Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1 | Nature Genetics | 2009 | 679 |
| 3 | Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016 | Modern Pathology | 2017 | 652 |
| 4 | Diffuse glioma growth: a guerilla war | Acta Neuropathologica | 2007 | 513 |
| 5 | Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity | Ultrasound in Medicine and Biology | 2009 | 456 |
| 6 | Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension | Nature Genetics | 2013 | 446 |
| 7 | Deficient mismatch repair system in patients with sporadic advanced colorectal cancer | British Journal of Cancer | 2009 | 392 |
| 8 | Sequence variant on 8q24 confers susceptibility to urinary bladder cancer | Nature Genetics | 2008 | 377 |
| 9 | Germline Mutation of INI1/SMARCB1 in Familial Schwannomatosis | American Journal of Human Genetics | 2007 | 360 |
| 10 | Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells | Cell Host and Microbe | 2018 | 358 |
| 11 | Prospective Multicentre Evaluation of PCA3 and TMPRSS2-ERG Gene Fusions as Diagnostic and Prognostic Urinary Biomarkers for Prostate Cancer | European Urology | 2014 | 306 |
| 12 | Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo)radiotherapy and total mesorectal excision: a Dutch Colorectal Cancer Group (DCCG) randomized phase III trial | Annals of Oncology | 2015 | 302 |
| 13 | MRI with a lymph-node-specific contrast agent as an alternative to CT scan and lymph-node dissection in patients with prostate cancer: a prospective multicohort study | Lancet Oncology, The | 2008 | 285 |
| 14 | Prospective Assessment of Prostate Cancer Aggressiveness Using 3-T Diffusion-Weighted Magnetic Resonance Imaging–Guided Biopsies Versus a Systematic 10-Core Transrectal Ultrasound Prostate Biopsy Cohort | European Urology | 2012 | 277 |
| 15 | KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2008 | 269 |
| 16 | High Expression Levels of Keratinocyte Antimicrobial Proteins in Psoriasis Compared with Atopic Dermatitis | Journal of Investigative Dermatology | 2005 | 262 |
| 17 | KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients | British Journal of Cancer | 2011 | 262 |
| 18 | Molecular diagnostics of gliomas: state of the art | Acta Neuropathologica | 2010 | 243 |
| 19 | In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma | Cancer Cell | 2010 | 238 |
| 20 | Hereditary diffuse gastric cancer: updated clinical practice guidelines | Lancet Oncology, The | 2020 | 237 |
| 21 | Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study | Lancet Oncology, The | 2011 | 232 |
| 22 | Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia | Gastroenterology | 2019 | 213 |
| 23 | Ciliopathies with Skeletal Anomalies and Renal Insufficiency due to Mutations in the IFT-A Gene WDR19 | American Journal of Human Genetics | 2011 | 210 |
| 24 | Comparison of Liquid-Based Cytology With Conventional Cytology for Detection of Cervical Cancer Precursors | JAMA - Journal of the American Medical Association | 2009 | 205 |
| 25 | Three-Tesla Magnetic Resonance–Guided Prostate Biopsy in Men With Increased Prostate-Specific Antigen and Repeated, Negative, Random, Systematic, Transrectal Ultrasound Biopsies: Detection of Clinically Significant Prostate Cancers | European Urology | 2012 | 204 |
| 26 | CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responsesin vivo | International Journal of Cancer | 2007 | 199 |
| 27 | Identification of a Candidate Gene Panel for the Early Diagnosis of Prostate Cancer | Clinical Cancer Research | 2015 | 193 |
| 28 | Receptor conversion in distant breast cancer metastases | Breast Cancer Research | 2010 | 189 |
| 29 | Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents | Annals of Oncology | 2010 | 183 |
| 30 | The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast | Breast Cancer Research and Treatment | 2010 | 180 |
| 31 | Prognostic significance and mechanism of Treg infiltration in human brain tumors | Journal of Neuroimmunology | 2010 | 180 |
| 32 | Deficiency of Dol-P-Man Synthase Subunit DPM3 Bridges the Congenital Disorders of Glycosylation with the Dystroglycanopathies | American Journal of Human Genetics | 2009 | 178 |
| 33 | Cerebral Microvascular Amyloid β Protein Deposition Induces Vascular Degeneration and Neuroinflammation in Transgenic Mice Expressing Human Vasculotropic Mutant Amyloid β Precursor Protein | American Journal of Pathology | 2005 | 177 |
| 34 | The Predictive Value of Endorectal 3 Tesla Multiparametric Magnetic Resonance Imaging for Extraprostatic Extension in Patients with Low, Intermediate and High Risk Prostate Cancer | Journal of Urology | 2013 | 177 |
| 35 | Biological correlates of FDG uptake in non-small cell lung cancer | Lung Cancer | 2007 | 174 |
| 36 | Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue | Journal of Biological Chemistry | 2008 | 172 |
| 37 | Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis | Neuromuscular Disorders | 2013 | 169 |
| 38 | Analysis of Mutations in B-RAF, N-RAS, and H-RAS Genes in the Differential Diagnosis of Spitz Nevus and Spitzoid Melanoma | American Journal of Surgical Pathology | 2005 | 167 |
| 39 | Vulvar squamous cell carcinoma development after diagnosis of VIN increases with age | European Journal of Cancer | 2009 | 167 |
| 40 | Chemoradiation therapy for rectal cancer in the distal rectum followed by organ-sparing transanal endoscopic microsurgery (CARTS study) | British Journal of Surgery | 2015 | 167 |
| 41 | Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme | BMC Cancer | 2009 | 166 |
| 42 | Tumour budding in solid cancers | Nature Reviews Clinical Oncology | 2021 | 166 |
| 43 | MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas | Laboratory Investigation | 2007 | 161 |
| 44 | Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma | Modern Pathology | 2011 | 159 |
| 45 | Mutations in DDHD2, Encoding an Intracellular Phospholipase A1, Cause a Recessive Form of Complex Hereditary Spastic Paraplegia | American Journal of Human Genetics | 2012 | 159 |
| 46 | KRAS gene amplification in colorectal cancer and impact on response to EGFR‐targeted therapy | International Journal of Cancer | 2013 | 154 |
| 47 | Advances in the care of patients with mucinous colorectal cancer | Nature Reviews Clinical Oncology | 2016 | 154 |
| 48 | Assessment of Prostate Cancer Aggressiveness Using Dynamic Contrast-enhanced Magnetic Resonance Imaging at 3 T | European Urology | 2013 | 152 |
| 49 | Long-term Oncological and Functional Outcomes of Chemoradiotherapy Followed by Organ-Sparing Transanal Endoscopic Microsurgery for Distal Rectal Cancer | JAMA Surgery | 2019 | 151 |
| 50 | Ki-67 as a prognostic marker in mantle cell lymphoma—consensus guidelines of the pathology panel of the European MCL Network | Journal of Hematopathology | 2009 | 149 |
