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Top Articles

#TitleJournalYearCitations
1Genetics of rheumatoid arthritis contributes to biology and drug discoveryNature20141,974
2EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 updateAnnals of the Rheumatic Diseases20141,688
3Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk lociNature Genetics20101,132
4Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT studyAnnals of the Rheumatic Diseases2014633
5The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin SensitivityCell Metabolism2010558
6Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritisJournal of Clinical Investigation2008450
7A simple sample size formula for analysis of covariance in randomized clinical trialsJournal of Clinical Epidemiology2007402
8The Disease Activity Score and the EULAR Response CriteriaRheumatic Disease Clinics of North America2009380
9The Disease Activity Score and the EULAR response criteriaClinical and Experimental Rheumatology2005342
10Preliminary criteria for the very early diagnosis of systemic sclerosis: results of a Delphi Consensus Study from EULAR Scleroderma Trials and Research GroupAnnals of the Rheumatic Diseases2011330
11Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritisAnnals of the Rheumatic Diseases2009329
12Meta-Analysis of Genome-Wide Association Studies in Celiac Disease and Rheumatoid Arthritis Identifies Fourteen Non-HLA Shared LociPLoS Genetics2011307
13The Macrophage Mannose Receptor Induces IL-17 in Response to Candida albicansCell Host and Microbe2009294
14Antiinflammatory and chondroprotective effects of intraarticular injection of adipose‐derived stem cells in experimental osteoarthritisArthritis and Rheumatism2012286
15Use of oral prednisolone or naproxen for the treatment of gout arthritis: a double-blind, randomised equivalence trialLancet, The2008254
16Dermatological conditions during TNF-alpha-blocking therapy in patients with rheumatoid arthritis: a prospective studyArthritis Research2005232
17Performance of four current risk algorithms in predicting cardiovascular events in patients with early rheumatoid arthritisAnnals of the Rheumatic Diseases2015222
18Highest clinical effectiveness of rituximab in autoantibody-positive patients with rheumatoid arthritis and in those for whom no more than one previous TNF antagonist has failed: pooled data from 10 European registriesAnnals of the Rheumatic Diseases2011188
19Human osteoarthritic synovium impacts chondrogenic differentiation of mesenchymal stem cells via macrophage polarisation stateOsteoarthritis and Cartilage2014188
20Immunochip Analysis Identifies Multiple Susceptibility Loci for Systemic SclerosisAmerican Journal of Human Genetics2014182
21Current evidence for the management of rheumatoid arthritis with synthetic disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritisAnnals of the Rheumatic Diseases2010179
22The efficacy of anti-TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practiceAnnals of the Rheumatic Diseases2007174
23Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll‐like receptor 4Arthritis and Rheumatism2012168
24Preliminary analysis of the Very Early Diagnosis of Systemic Sclerosis (VEDOSS) EUSTAR multicentre study: evidence for puffy fingers as a pivotal sign for suspicion of systemic sclerosisAnnals of the Rheumatic Diseases2014168
25Myeloid-related proteins S100A8/S100A9 regulate joint inflammation and cartilage destruction during antigen-induced arthritisAnnals of the Rheumatic Diseases2008161
26Performance of response criteria for assessing peripheral arthritis in patients with psoriatic arthritis: analysis of data from randomised controlled trials of two tumour necrosis factor inhibitorsAnnals of the Rheumatic Diseases2006151
27Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activityNature Communications2014150
28Toll-like receptors and chronic inflammation in rheumatic diseases: new developmentsNature Reviews Rheumatology2016150
29Long-term follow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosisAnnals of the Rheumatic Diseases2008149
30Smad Signaling Determines Chondrogenic Differentiation of Bone-Marrow-Derived Mesenchymal Stem Cells: Inhibition of Smad1/5/8P Prevents Terminal Differentiation and CalcificationTissue Engineering - Part A2011149
31Cognitive-behavioural therapies and exercise programmes for patients with fibromyalgia: state of the art and future directionsAnnals of the Rheumatic Diseases2007144
32A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registryAnnals of the Rheumatic Diseases2012141
33Modulation of lipoprotein plasma concentrations during long-term anti-TNF therapy in patients with active rheumatoid arthritisAnnals of the Rheumatic Diseases2007136
34Chronic skin inflammation leads to bone loss by IL-17–mediated inhibition of Wnt signaling in osteoblastsScience Translational Medicine2016133
35Common and different genetic background for rheumatoid arthritis and coeliac diseaseHuman Molecular Genetics2009128
36Efficacy and safety of combination etanercept and methotrexate versus etanercept alone in patients with rheumatoid arthritis with an inadequate response to methotrexate: the ADORE studyAnnals of the Rheumatic Diseases2006125
37Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registryAnnals of the Rheumatic Diseases2013124
38Excess mortality emerges after 10 years in an inception cohort of early rheumatoid arthritisArthritis Care and Research2010122
39Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic SclerosisJournal of Investigative Dermatology2010121
40Meta-analysis of tight control strategies in rheumatoid arthritis: protocolized treatment has additional value with respect to the clinical outcomeRheumatology2010121
41The effect of disease duration and disease activity on the risk of cardiovascular disease in rheumatoid arthritis patientsAnnals of the Rheumatic Diseases2015121
42Tumor necrosis factor–interleukin‐17 interplay induces S100A8, interleukin‐1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: Rationale for combination treatment during arthritisArthritis and Rheumatism2011119
43Linkage of Periodontitis and Rheumatoid Arthritis: Current Evidence and Potential Biological InteractionsInternational Journal of Molecular Sciences2019115
44Persistent severe fatigue in patients with rheumatoid arthritisJournal of Clinical Nursing2007113
45Is the disease course of rheumatoid arthritis becoming milder?: Time trends since 1985 in an inception cohort of early rheumatoid arthritisArthritis and Rheumatism2005112
46Anti-inflammatory therapy with tumour necrosis factor alpha inhibitors improves high-density lipoprotein cholesterol antioxidative capacity in rheumatoid arthritis patientsAnnals of the Rheumatic Diseases2009112
47Assessing the Quality of Clinical TeachersJournal of General Internal Medicine2010111
48Selective Activation of Adenosine A 2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid ArthritisScience Translational Medicine2012111
49Inflammation-dependent secretion and splicing of IL-32γ in rheumatoid arthritisProceedings of the National Academy of Sciences of the United States of America2011108
50Construct and criterion validity of several proposed DAS28-based rheumatoid arthritis flare criteria: an OMERACT cohort validation studyAnnals of the Rheumatic Diseases2013106