| # | Title | Journal | Year | Citations |
|---|
| 1 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Acta Neuropathologica | 2016 | 12,144 |
| 2 | The 2007 WHO Classification of Tumours of the Central Nervous System | Acta Neuropathologica | 2007 | 9,898 |
| 3 | The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia | Blood | 2016 | 7,429 |
| 4 | A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments] | Blood | 1994 | 6,150 |
| 5 | The 2021 WHO Classification of Tumors of the Central Nervous System: a summary | Neuro-Oncology | 2021 | 4,534 |
| 6 | The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes | Blood | 2009 | 3,864 |
| 7 | Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion | Cell | 2005 | 3,273 |
| 8 | Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors | Science Translational Medicine | 2011 | 2,938 |
| 9 | Discovery and saturation analysis of cancer genes across 21 tumour types | Nature | 2014 | 2,586 |
| 10 | Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease | Neurology | 1992 | 2,379 |
| 11 | Consensus statement on the pathology of IgG4-related disease | Modern Pathology | 2012 | 2,171 |
| 12 | Prediction of central nervous system embryonal tumour outcome based on gene expression | Nature | 2002 | 2,154 |
| 13 | International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas | Pancreatology | 2012 | 2,043 |
| 14 | Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer | Nature Medicine | 2004 | 1,852 |
| 15 | Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK | Journal of Clinical Oncology | 2009 | 1,775 |
| 16 | The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications | Blood | 2011 | 1,681 |
| 17 | AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients | Cancer Cell | 2007 | 1,675 |
| 18 | Soluble endoglin contributes to the pathogenesis of preeclampsia | Nature Medicine | 2006 | 1,653 |
| 19 | Functional Arteries Grown in Vitro | Science | 1999 | 1,626 |
| 20 | Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters | Cell | 2008 | 1,504 |
| 21 | Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes | Blood | 2015 | 1,493 |
| 22 | Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis | Genes and Development | 2000 | 1,452 |
| 23 | Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration | Nature | 1999 | 1,424 |
| 24 | Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis | Nature | 2003 | 1,395 |
| 25 | Functional genomics reveal that the serine synthesis pathway is essential in breast cancer | Nature | 2011 | 1,359 |
| 26 | Identification of cells initiating human melanomas | Nature | 2008 | 1,327 |
| 27 | TALENs: a widely applicable technology for targeted genome editing | Nature Reviews Molecular Cell Biology | 2013 | 1,326 |
| 28 | A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group | Blood | 1994 | 1,323 |
| 29 | Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study | Gastroenterology | 2004 | 1,293 |
| 30 | Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma | Cell | 2018 | 1,260 |
| 31 | Expanded encyclopaedias of DNA elements in the human and mouse genomes | Nature | 2020 | 1,252 |
| 32 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms | Leukemia | 2022 | 1,211 |
| 33 | Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma | JAMA Oncology | 2016 | 1,192 |
| 34 | Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity | Cell | 2021 | 1,166 |
| 35 | STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma | Cancer Discovery | 2018 | 1,108 |
| 36 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 37 | American Cancer Society, American Society for Colposcopy and Cervical Pathology, and American Society for Clinical Pathology screening guidelines for the prevention and early detection of cervical cancer | Ca-A Cancer Journal for Clinicians | 2012 | 1,022 |
| 38 | Charting histone modifications and the functional organization of mammalian genomes | Nature Reviews Genetics | 2011 | 1,019 |
| 39 | Hydrogen Peroxide: A Signaling Messenger | Antioxidants and Redox Signaling | 2006 | 1,001 |
| 40 | Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness | Science | 1981 | 995 |
| 41 | Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia | Nature | 2010 | 980 |
| 42 | EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non–Small Cell Lung Cancer: A Retrospective Analysis | Clinical Cancer Research | 2016 | 977 |
| 43 | Molecular Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors inALK-Rearranged Lung Cancer | Cancer Discovery | 2016 | 919 |
| 44 | Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound | Journal of the American College of Cardiology | 2002 | 918 |
| 45 | Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma | Acta Neuropathologica | 2011 | 914 |
| 46 | Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells | Science Translational Medicine | 2013 | 910 |
| 47 | mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant | Cell | 2022 | 881 |
| 48 | Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation | Immunity | 2002 | 879 |
| 49 | A revised airway epithelial hierarchy includes CFTR-expressing ionocytes | Nature | 2018 | 878 |
| 50 | Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics | Science | 2002 | 869 |
