| # | Title | Journal | Year | Citations |
|---|
| 1 | Antibody–Drug Conjugates: A Comprehensive Review | Molecular Cancer Research | 2020 | 442 |
| 2 | Processing of Transforming Growth Factor β1 Precursor by Human Furin Convertase | Journal of Biological Chemistry | 1995 | 341 |
| 3 | High Rate of Recurrent De Novo Mutations in Developmental and Epileptic Encephalopathies | American Journal of Human Genetics | 2017 | 337 |
| 4 | Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry | Pediatric Neurology | 2017 | 213 |
| 5 | The D -dopachrome tautomerase ( DDT ) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF) | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 185 |
| 6 | Asbestos Fibers and Silica Particles Stimulate Rat Alveolar Macrophages To Release Tumor Necrosis Factor: Autoregulatory Role of Leukotriene B4 | The American Review of Respiratory Disease | 1989 | 181 |
| 7 | CysLT1 receptor upregulation by TGF-β and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4 | Journal of Allergy and Clinical Immunology | 2003 | 174 |
| 8 | IL-13 and IL-4 Up-Regulate Cysteinyl Leukotriene 1 Receptor Expression in Human Monocytes and Macrophages | Journal of Immunology | 2001 | 151 |
| 9 | Immunoregulation by leukotrienes and other lipoxygenase metabolites | Trends in Immunology | 1985 | 147 |
| 10 | Effect of Alipogene Tiparvovec (AAV1-LPLS447X) on Postprandial Chylomicron Metabolism in Lipoprotein Lipase-Deficient Patients | Journal of Clinical Endocrinology and Metabolism | 2012 | 146 |
| 11 | Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord | PLoS Genetics | 2008 | 131 |
| 12 | SOCS1 Links Cytokine Signaling to p53 and Senescence | Molecular Cell | 2009 | 128 |
| 13 | Maternal and Cord-Blood Thyroid Hormone Levels and Exposure to Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls During Early Pregnancy | American Journal of Epidemiology | 2013 | 120 |
| 14 | TGFbeta1 regulates gene expression of its own converting enzyme furin. | Journal of Clinical Investigation | 1997 | 118 |
| 15 | Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea | Human Molecular Genetics | 2015 | 111 |
| 16 | Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database | Human Mutation | 2012 | 109 |
| 17 | Transforming growth factor-beta regulates c-kit message stability and cell-surface protein expression in hematopoietic progenitors | Blood | 1994 | 106 |
| 18 | Sizing the ends: Normal length of human telomeres | Annals of Anatomy | 2010 | 96 |
| 19 | Efficient analysis of urinary glycosaminoglycans by LC-MS/MS in mucopolysaccharidoses type I, II and VI | Molecular Genetics and Metabolism | 2011 | 96 |
| 20 | How well does urinary lyso-Gb3 function as a biomarker in Fabry disease? | Clinica Chimica Acta | 2010 | 94 |
| 21 | TACE/ADAM-17 maturation and activation of sheddase activity require proprotein convertase activity | FEBS Letters | 2003 | 92 |
| 22 | Developmental motor deficits induced by combined fetal exposure to lipopolysaccharide and early neonatal hypoxia/ischemia: A novel animal model for cerebral palsy in very premature infants | Neuroscience | 2009 | 91 |
| 23 | USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation | Nature Immunology | 2017 | 90 |
| 24 | A postpartum vaccination promotion intervention using motivational interviewing techniques improves short-term vaccine coverage: PromoVac study | BMC Public Health | 2018 | 90 |
| 25 | Urinary globotriaosylceramide excretion correlates with the genotype in children and adults with Fabry disease | Molecular Genetics and Metabolism | 2008 | 88 |
| 26 | IL-6, in Synergy with IL-7 or IL-15, Stimulates TCR-Independent Proliferation and Functional Differentiation of CD8+ T Lymphocytes | Journal of Immunology | 2008 | 86 |
| 27 | Standardized annotation of translated open reading frames | Nature Biotechnology | 2022 | 86 |
| 28 | Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether]: Reversal by a specific antagonist, BN 52021 | Biochemical and Biophysical Research Communications | 1987 | 85 |
| 29 | The Outcomes of Children With Pediatric Acute Respiratory Distress Syndrome | Pediatric Critical Care Medicine | 2015 | 84 |
| 30 | Analysis of Glycosaminoglycans in Cerebrospinal Fluid from Patients with Mucopolysaccharidoses by Isotope-Dilution Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry | Clinical Chemistry | 2011 | 83 |
| 31 | Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes | Prostaglandins | 1987 | 82 |
| 32 | Urinary Globotriaosylsphingosine-Related Biomarkers for Fabry Disease Targeted by Metabolomics | Analytical Chemistry | 2012 | 82 |
| 33 | Silymarin impacts on immune system as an immunomodulator: One key for many locks | International Immunopharmacology | 2017 | 81 |
| 34 | Motivational interviewing: A powerful tool to address vaccine hesitancy | Canada Communicable Disease Report | 2020 | 81 |
| 35 | SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes | Aging | 2017 | 76 |
| 36 | IL-5 Up-Regulates Cysteinyl Leukotriene 1 Receptor Expression in HL-60 Cells Differentiated into Eosinophils | Journal of Immunology | 2000 | 74 |
| 37 | Multiplex Analysis of Novel Urinary Lyso-Gb3-Related Biomarkers for Fabry Disease by Tandem Mass Spectrometry | Analytical Chemistry | 2013 | 72 |
| 38 | Trafficking, Ubiquitination, and Down-regulation of the Human Platelet-activating Factor Receptor | Journal of Biological Chemistry | 2003 | 71 |
| 39 | Fibroblast Growth Factor 2 and Transforming Growth Factor β1 Synergism in Human Bronchial Smooth Muscle Cell Proliferation | American Journal of Respiratory Cell and Molecular Biology | 2006 | 71 |
| 40 | Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK) | PLoS ONE | 2011 | 71 |
| 41 | Multiplex Tandem Mass Spectrometry Analysis of Novel Plasma Lyso-Gb3-Related Analogues in Fabry Disease | Analytical Chemistry | 2014 | 71 |
| 42 | Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17 | Journal of Pineal Research | 2015 | 68 |
| 43 | Tandem Mass Spectrometry Multiplex Analysis of Glucosylceramide and Galactosylceramide Isoforms in Brain Tissues at Different Stages of Parkinson Disease | Analytical Chemistry | 2016 | 68 |
| 44 | Nuclear Translocation of β-Actin Is Involved in Transcriptional Regulation during Macrophage Differentiation of HL-60 Cells | Molecular Biology of the Cell | 2010 | 67 |
| 45 | NLR-Dependent Regulation of Inflammation in Multiple Sclerosis | Frontiers in Immunology | 2017 | 66 |
| 46 | Proprotein cleavage of E-cadherin by furin in baculovirus over-expression system: potential role of other convertases in mammalian cells | FEBS Letters | 1998 | 64 |
| 47 | Quebec neonatal mass urinary screening programme: From micromolecules to macromolecules | Journal of Inherited Metabolic Disease | 2007 | 62 |
| 48 | An improved method for glycosaminoglycan analysis by LC–MS/MS of urine samples collected on filter paper | Clinica Chimica Acta | 2012 | 62 |
| 49 | Effect of lovastatin on behavior in children and adults with fragile X syndrome: An open‐label study | American Journal of Medical Genetics, Part A | 2014 | 62 |
| 50 | Immunization of preterm infants | Human Vaccines and Immunotherapeutics | 2015 | 62 |
