| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | ERK and cell death: Mechanisms of ERK‐induced cell death – apoptosis, autophagy and senescence | FEBS Journal | 2010 | 1,064 |
| 3 | Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes? | Frontiers in Immunology | 2017 | 831 |
| 4 | Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis | BMJ, The | 2020 | 673 |
| 5 | MIQE précis: Practical implementation of minimum standard guidelines for fluorescence-based quantitative real-time PCR experiments | BMC Molecular Biology | 2010 | 563 |
| 6 | Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans | Seminars in Immunology | 2012 | 446 |
| 7 | Antibody–Drug Conjugates: A Comprehensive Review | Molecular Cancer Research | 2020 | 442 |
| 8 | Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release | Cells | 2019 | 357 |
| 9 | The need for transparency and good practices in the qPCR literature | Nature Methods | 2013 | 251 |
| 10 | Cohort Profile: The Canadian Longitudinal Study on Aging (CLSA) | International Journal of Epidemiology | 2019 | 237 |
| 11 | The integration of inflammaging in age-related diseases | Seminars in Immunology | 2018 | 234 |
| 12 | Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? | American Journal of Epidemiology | 2018 | 216 |
| 13 | Modeling factors explaining the acceptance, actual use and satisfaction of nurses using an Electronic Patient Record in acute care settings: An extension of the UTAUT | International Journal of Medical Informatics | 2015 | 206 |
| 14 | The emerging landscape of small nucleolar RNAs in cell biology | Wiley Interdisciplinary Reviews RNA | 2015 | 193 |
| 15 | Defective control of pre–messenger RNA splicing in human disease | Journal of Cell Biology | 2016 | 182 |
| 16 | β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1 | Biogerontology | 2015 | 170 |
| 17 | Beliefs in Conspiracy Theories and Misinformation About COVID-19: Comparative Perspectives on the Role of Anxiety, Depression and Exposure to and Trust in Information Sources | Frontiers in Psychology | 2021 | 160 |
| 18 | Predictors of long-term participation after stroke | Disability and Rehabilitation | 2006 | 157 |
| 19 | The Role of Immunosenescence in the Development of Age-Related Diseases | Revista De Investigacion Clinica | 2016 | 155 |
| 20 | Oxidation Reactions of Cytosine DNA Components by Hydroxyl Radical and One-Electron Oxidants in Aerated Aqueous Solutions | Accounts of Chemical Research | 2010 | 151 |
| 21 | ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability | Nucleic Acids Research | 2015 | 151 |
| 22 | The rising prevalence of prescription opioid injection and its association with hepatitis C incidence among street‐drug users | Addiction | 2012 | 149 |
| 23 | Dual-acting riboswitch control of translation initiation and mRNA decay | Proceedings of the National Academy of Sciences of the United States of America | 2012 | 144 |
| 24 | The emerging role of alternative splicing in senescence and aging | Aging Cell | 2017 | 141 |
| 25 | 20th Anniversary Ottawa Decision Support Framework: Part 3 Overview of Systematic Reviews and Updated Framework | Medical Decision Making | 2020 | 140 |
| 26 | Cellular signaling in the aging immune system | Current Opinion in Immunology | 2014 | 139 |
| 27 | Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2 | Cells | 2020 | 138 |
| 28 | The neural control of interlimb coordination during mammalian locomotion | Journal of Neurophysiology | 2017 | 133 |
| 29 | Human Inflammaging | Gerontology | 2019 | 133 |
| 30 | Disruption of AP1S1, Causing a Novel Neurocutaneous Syndrome, Perturbs Development of the Skin and Spinal Cord | PLoS Genetics | 2008 | 131 |
| 31 | Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada | Reproductive Toxicology | 2011 | 129 |
| 32 | Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist‐treated rats | Journal of Neurochemistry | 2008 | 128 |
| 33 | Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer | Oncogene | 2015 | 128 |
| 34 | From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation | Biogerontology | 2016 | 128 |
| 35 | Polymeric Binders Suppress Gliadin-Induced Toxicity in the Intestinal Epithelium | Gastroenterology | 2009 | 127 |
| 36 | Individual predictors of frequent emergency department use: a scoping review | BMC Health Services Research | 2016 | 123 |
| 37 | In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials | MBio | 2020 | 123 |
| 38 | Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity | | 2018 | 121 |
| 39 | Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model | Journal of Alzheimer's Disease | 2016 | 120 |
| 40 | Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis | Molecular Carcinogenesis | 2016 | 120 |
| 41 | PCSK9 plays a significant role in cholesterol homeostasis and lipid transport in intestinal epithelial cells | Atherosclerosis | 2013 | 118 |
| 42 | Granulocyte-Macrophage Colony-Stimulating Factor Prevents Diabetes Development in NOD Mice by Inducing Tolerogenic Dendritic Cells that Sustain the Suppressive Function of CD4+CD25+ Regulatory T Cells | Journal of Immunology | 2007 | 116 |
| 43 | Endings in the middle: Current knowledge of interstitial telomeric sequences | Mutation Research - Reviews in Mutation Research | 2008 | 115 |
| 44 | Role of the peripheral innate immune system in the development of Alzheimer's disease | Experimental Gerontology | 2018 | 114 |
| 45 | Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain | Behavioural Brain Research | 2012 | 113 |
| 46 | Lower vitamin D levels at first trimester are associated with higher risk of developing gestational diabetes mellitus | Acta Diabetologica | 2014 | 113 |
| 47 | 17,18-Epoxyeicosatetraenoic Acid Targets PPARγ and p38 Mitogen–Activated Protein Kinase to Mediate Its Anti-inflammatory Effects in the Lung | American Journal of Respiratory Cell and Molecular Biology | 2010 | 112 |
| 48 | Relation between mealtime distribution of protein intake and lean mass loss in free-living older adults of the NuAge study | American Journal of Clinical Nutrition | 2016 | 109 |
| 49 | A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic | Nature | 2022 | 108 |
| 50 | Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors | Science Signaling | 2018 | 106 |
