Institute of Technical Biochemistry

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#	Title	Journal	Year	Citations
1	Anatomy of lipase binding sites: the scissile fatty acid binding site	Chemistry and Physics of Lipids	1998	395
2	Cytochrome P450 monooxygenases: perspectives for synthetic application	Trends in Biotechnology	2006	268
3	The Lipase Engineering Database: a navigation and analysis tool for protein families	Nucleic Acids Research	2003	220
4	Cloning and characterization of a new laccase from Bacillus licheniformis catalyzing dimerization of phenolic acids	Applied Microbiology and Biotechnology	2008	203
5	Microbial biofilms: a concept for industrial catalysis?	Trends in Biotechnology	2009	191
6	Recent progress in industrial biocatalysis	Current Opinion in Chemical Biology	2011	184
7	Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals	Angewandte Chemie - International Edition	2019	169
8	Reporter gene bioassays in environmental analysis	Fresenius' Journal of Analytical Chemistry	2000	155
9	Lipase engineering database	Journal of Molecular Catalysis B: Enzymatic	2000	147
10	Modeling structure and flexibility of Candida antarctica lipase B in organic solvents	BMC Structural Biology	2008	147
11	Design of acetylcholinesterases for biosensor applications	Biosensors and Bioelectronics	2003	144
12	Development of a DNA Microarray for Detection and Identification of Fungal Pathogens Involved in Invasive Mycoses	Journal of Clinical Microbiology	2005	140
13	Effects of methanol on lipases: Molecular, kinetic and process issues in the production of biodiesel	Biotechnology Journal	2015	140
14	Activity of Lipases and Esterases towards Tertiary Alcohols: Insights into Structure��Function Relationships	Angewandte Chemie - International Edition	2002	139
15	Rational Design of a Minimal and Highly Enriched CYP102A1 Mutant Library with Improved Regio‐, Stereo‐ and Chemoselectivity	ChemBioChem	2009	133
16	Engineering of Flexible Loops in Enzymes	ACS Catalysis	2014	132
17	Functional Role of Lanthanides in Enzymatic Activity and Transcriptional Regulation of Pyrroloquinoline Quinone-Dependent Alcohol Dehydrogenases in Pseudomonas putida KT2440	MBio	2017	131
18	Immobilisation of P450 BM-3 and an NADP+ Cofactor Recycling System: Towards a Technical Application of Heme-Containing Monooxygenases in Fine Chemical Synthesis	Advanced Synthesis and Catalysis	2003	121
19	Solvent‐induced lid opening in lipases: A molecular dynamics study	Protein Science	2010	120
20	The PHA Depolymerase Engineering Database: A systematic analysis tool for the diverse family of polyhydroxyalkanoate (PHA) depolymerases	BMC Bioinformatics	2009	116
21	Redox properties of cytochrome P450BM3measured by direct methods	FEBS Journal	2003	113
22	Use of DNA Microarrays for Rapid Genotyping of TEM Beta-Lactamases That Confer Resistance	Journal of Clinical Microbiology	2004	113
23	Prediction and analysis of the modular structure of cytochrome P450 monooxygenases	BMC Structural Biology	2010	112
24	A Molecular Mechanism of Enantiorecognition of Tertiary Alcohols by Carboxylesterases	ChemBioChem	2003	107
25	Molecular modeling of family GH16 glycoside hydrolases: Potential roles for xyloglucan transglucosylases/hydrolases in cell wall modification in the poaceae	Protein Science	2009	104
26	The Laccase Engineering Database: a classification and analysis system for laccases and related multicopper oxidases	Database: the Journal of Biological Databases and Curation	2011	103
27	Cytochrome P450 monooxygenase from Clostridium acetobutylicum: A new α-fatty acid hydroxylase	Biochemical and Biophysical Research Communications	2007	101
28	Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases	ChemBioChem	2014	98
29	Catalytic Hydroxylation in Biphasic Systems using CYP102A1 Mutants	Advanced Synthesis and Catalysis	2005	97
30	Ethylene Glycol Metabolism by Pseudomonas putida	Applied and Environmental Microbiology	2012	96
31	Imine Reductase‐Catalyzed Intermolecular Reductive Amination of Aldehydes and Ketones	ChemCatChem	2015	96
32	Characterization of the versatile monooxygenase CYP109B1 from Bacillus subtilis	Applied Microbiology and Biotechnology	2010	93
33	Bacterial CYP153A monooxygenases for the synthesis of omega-hydroxylated fatty acids	Chemical Communications	2012	92
34	Multiple molecular dynamics simulations of human p450 monooxygenase CYP2C9: The molecular basis of substrate binding and regioselectivity toward warfarin	Proteins: Structure, Function and Bioinformatics	2006	90
35	Terpene Cyclizations inside a Supramolecular Catalyst: Leaving-Group-Controlled Product Selectivity and Mechanistic Studies	Journal of the American Chemical Society	2017	90
36	Improving the functional expression of a Bacillus licheniformislaccase by random and site-directed mutagenesis	BMC Biotechnology	2009	89
37	Lipase-catalyzed synthesis of vitamin C fatty acid esters	Biotechnology Letters	1999	88
38	Molecular cloning and characterization of thermostable esterase and lipase from Geobacillus thermoleovorans YN isolated from desert soil in Egypt	Process Biochemistry	2007	88
39	Regioselective biooxidation of (+)-valencene by recombinant E. coli expressing CYP109B1 from Bacillus subtilis in a two-liquid-phase system	Microbial Cell Factories	2009	87
40	Stereoselectivity of Pseudomonas cepacia lipase toward secondary alcohols: A quantitative model	Protein Science	2000	85
41	Lipase-catalyzed solid-phase synthesis of sugar fatty acid esters	Enzyme and Microbial Technology	1999	84
42	Synthesis of ω‐hydroxy dodecanoic acid based on an engineered CYP153A fusion construct	Microbial Biotechnology	2013	83
43	Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis	Nature Chemical Biology	2015	83
44	Regioselective ω-hydroxylation of medium-chain n-alkanes and primary alcohols by CYP153 enzymes from Mycobacterium marinum and Polaromonas sp. strain JS666	Organic and Biomolecular Chemistry	2011	82
45	Biotransformation of β-ionone by engineered cytochrome P450 BM-3	Applied Microbiology and Biotechnology	2006	80
46	Structural classification by the Lipase Engineering Database: a case study of Candida antarctica lipase A	BMC Genomics	2010	78
47	Comparative characterization of four laccases from Trametes versicolor concerning phenolic C–C coupling and oxidation of PAHs	Archives of Biochemistry and Biophysics	2008	73
48	Engineering stereoselectivity of ThDP-dependent enzymes	FEBS Journal	2013	72
49	The folding and activity of the extracellular lipase of Rhizopus oryzae are modulated by a prosequence	Biochemical Journal	1996	71
50	Integrated Detection of Extended-Spectrum-Beta-Lactam Resistance by DNA Microarray-Based Genotyping of TEM, SHV, and CTX-M Genes	Journal of Clinical Microbiology	2010	70

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