| # | Title | Journal | Year | Citations |
|---|
| 1 | Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis | Nature | 2010 | 4,648 |
| 2 | Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 | Leukemia | 2003 | 2,788 |
| 3 | Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis | Blood | 1994 | 2,012 |
| 4 | The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells | Cell | 2002 | 1,897 |
| 5 | Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis | Blood | 1994 | 1,794 |
| 6 | Landscape of somatic mutations in 560 breast cancer whole-genome sequences | Nature | 2016 | 1,760 |
| 7 | Genes that mediate breast cancer metastasis to the brain | Nature | 2009 | 1,587 |
| 8 | The landscape of cancer genes and mutational processes in breast cancer | Nature | 2012 | 1,535 |
| 9 | Very high risk of cancer in familial Peutz–Jeghers syndrome | Gastroenterology | 2000 | 1,247 |
| 10 | Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters | Nature Genetics | 2011 | 1,080 |
| 11 | Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis | Blood | 1994 | 771 |
| 12 | HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures | Nature Medicine | 2017 | 769 |
| 13 | Systematic Analysis of Breast Cancer Morphology Uncovers Stromal Features Associated with Survival | Science Translational Medicine | 2011 | 603 |
| 14 | Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2005 | 595 |
| 15 | An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms | Journal of Pathology | 1994 | 500 |
| 16 | Distribution of macrophage polarization markers in human atherosclerosis | Atherosclerosis | 2012 | 490 |
| 17 | EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations | Leukemia | 2012 | 409 |
| 18 | Neuroinflammation in Alzheimer's disease and prion disease | Glia | 2002 | 393 |
| 19 | Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets | Oncogene | 2010 | 385 |
| 20 | EphB receptor activity suppresses colorectal cancer progression | Nature | 2005 | 375 |
| 21 | Neuroblastoma is composed of two super-enhancer-associated differentiation states | Nature Genetics | 2017 | 362 |
| 22 | Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes | Science | 2014 | 348 |
| 23 | Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation | Nature Genetics | 2004 | 343 |
| 24 | The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation | Cancer Research | 2010 | 326 |
| 25 | Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936 | Leukemia | 2007 | 292 |
| 26 | Methylation of Cancer-Stem-Cell-Associated Wnt Target Genes Predicts Poor Prognosis in Colorectal Cancer Patients | Cell Stem Cell | 2011 | 291 |
| 27 | Stepwise radical endoscopic resection versus radiofrequency ablation for Barrett's oesophagus with high-grade dysplasia or early cancer: a multicentre randomised trial | Gut | 2011 | 267 |
| 28 | Multiple Immunoenzyme Staining: Methods and Visualizations for the Observation With Spectral Imaging | Journal of Histochemistry and Cytochemistry | 2008 | 254 |
| 29 | Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon | Gastroenterology | 2004 | 246 |
| 30 | Assessment of middle cerebral artery diameter during hypocapnia and hypercapnia in humans using ultra-high-field MRI | Journal of Applied Physiology | 2014 | 246 |
| 31 | Remission of Barrett's Esophagus With Early Neoplasia 5 Years After Radiofrequency Ablation With Endoscopic Resection: A Netherlands Cohort Study | Gastroenterology | 2013 | 237 |
| 32 | The topography of mutational processes in breast cancer genomes | Nature Communications | 2016 | 235 |
| 33 | Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement | Annals of Oncology | 2012 | 233 |
| 34 | Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain | Acta Neuropathologica | 2001 | 229 |
| 35 | Somatic mutations reveal asymmetric cellular dynamics in the early human embryo | Nature | 2017 | 229 |
| 36 | Relative frequency and morphology of cancers in STK11 mutation carriers1 ☆ | Gastroenterology | 2004 | 228 |
| 37 | Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer | Clinical Cancer Research | 2001 | 226 |
| 38 | Local Immune Response in Skin of Generalized Vitiligo Patients | Laboratory Investigation | 2000 | 225 |
| 39 | Constitutive CD27/CD70 Interaction Induces Expansion of Effector-Type T Cells and Results in IFNγ-Mediated B Cell Depletion | Immunity | 2001 | 224 |
| 40 | Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-3936 | Leukemia | 2007 | 222 |
| 41 | Assessment of Future Remnant Liver Function Using Hepatobiliary Scintigraphy in Patients Undergoing Major Liver Resection | Journal of Gastrointestinal Surgery | 2010 | 218 |
| 42 | Immunopolarization of CD4+ and CD8+ T Cells to Type-1–Like is Associated with Melanocyte Loss in Human Vitiligo | Laboratory Investigation | 2003 | 212 |
| 43 | Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial | Kidney International | 2006 | 208 |
| 44 | Development and validation of the WASP classification system for optical diagnosis of adenomas, hyperplastic polyps and sessile serrated adenomas/polyps | Gut | 2016 | 208 |
| 45 | Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer | Oncogene | 2009 | 201 |
| 46 | Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases | Diagnostic Pathology | 2014 | 200 |
| 47 | Ultrasensitive in situ visualization of active glucocerebrosidase molecules | Nature Chemical Biology | 2010 | 196 |
| 48 | Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity | Journal of Experimental Medicine | 2005 | 193 |
| 49 | Receptor conversion in distant breast cancer metastases | Breast Cancer Research | 2010 | 189 |
| 50 | Endoscopic features of sessile serrated adenomas: validation by international experts using high-resolution white-light endoscopy and narrow-band imaging | Gastrointestinal Endoscopy | 2013 | 189 |
