| # | Title | Journal | Year | Citations |
|---|
| 1 | Osteoarthritis cartilage histopathology: grading and staging | Osteoarthritis and Cartilage | 2006 | 1,755 |
| 2 | Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions | Journal of Biological Chemistry | 1997 | 1,448 |
| 3 | Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection | Molecular Therapy | 2008 | 1,143 |
| 4 | The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA | Nature | 2003 | 969 |
| 5 | Guanylyl cyclases and signaling by cyclic GMP | Pharmacological Reviews | 2000 | 945 |
| 6 | Leptin: The Tale of an Obesity Gene | Diabetes | 1996 | 928 |
| 7 | The complex transcriptional landscape of the anucleate human platelet | BMC Genomics | 2013 | 913 |
| 8 | Drug-Related Hepatotoxicity | New England Journal of Medicine | 2006 | 908 |
| 9 | Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen | Journal of Biological Chemistry | 2002 | 755 |
| 10 | Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro | Diabetes | 1996 | 722 |
| 11 | Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition | Nature Reviews Cancer | 2007 | 720 |
| 12 | Histological outcome during long-term lamivudine therapy | Gastroenterology | 2003 | 714 |
| 13 | Infection withMycobacterium aviumComplex in Patients without Predisposing Conditions | New England Journal of Medicine | 1989 | 709 |
| 14 | Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes | Nature Medicine | 2007 | 708 |
| 15 | Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. | Journal of Clinical Investigation | 1996 | 658 |
| 16 | An empirical study of decline in empathy in medical school | Medical Education | 2004 | 653 |
| 17 | NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis | Osteoarthritis and Cartilage | 2006 | 588 |
| 18 | Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function | Journal of Clinical Endocrinology and Metabolism | 2004 | 584 |
| 19 | Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment | American Journal of Obstetrics and Gynecology | 1992 | 563 |
| 20 | Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator | Diabetes | 1995 | 535 |
| 21 | Responses of Leptin to Short-Term Fasting and Refeeding in Humans: A Link With Ketogenesis but Not Ketones Themselves | Diabetes | 1996 | 471 |
| 22 | The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H 2 O 2 and Plays an Integral Role in Insulin Signal Transduction | Molecular and Cellular Biology | 2004 | 471 |
| 23 | AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer | Journal of Physiology | 2006 | 457 |
| 24 | Identification of Fetal DNA and Cells in Skin Lesions from Women with Systemic Sclerosis | New England Journal of Medicine | 1998 | 452 |
| 25 | Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade | Journal of Biological Chemistry | 2001 | 444 |
| 26 | Evidence of free and bound leptin in human circulation. Studies in lean and obese subjects and during short-term fasting. | Journal of Clinical Investigation | 1996 | 443 |
| 27 | Human Immunodeficiency Virus Type 1 in the Semen of Men Receiving Highly Active Antiretroviral Therapy | New England Journal of Medicine | 1998 | 443 |
| 28 | The use of the dilute Russell viper venom time for the diagnosis of lupus anticoagulants | Blood | 1986 | 436 |
| 29 | Cardiopoietic Stem Cell Therapy in Heart Failure | Journal of the American College of Cardiology | 2013 | 427 |
| 30 | Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat Adipocytes | Diabetes | 2003 | 416 |
| 31 | Diabetic kidney disease in thedb/dbmouse | American Journal of Physiology - Renal Physiology | 2003 | 415 |
| 32 | Cellular reservoirs of HIV-1 in the central nervous system of infected individuals | Aids | 1996 | 413 |
| 33 | Residual HIV-1 RNA in Blood Plasma of Patients Taking Suppressive Highly Active Antiretroviral Therapy | JAMA - Journal of the American Medical Association | 1999 | 396 |
| 34 | Differential Regulation of Adiponectin Secretion from Cultured Human Omental and Subcutaneous Adipocytes: Effects of Insulin and Rosiglitazone | Journal of Clinical Endocrinology and Metabolism | 2002 | 391 |
| 35 | Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus | Gastroenterology | 2004 | 389 |
| 36 | The risks and benefits of long‐term use of hydroxyurea in sickle cell anemia: A 17.5 year follow‐up | American Journal of Hematology | 2010 | 385 |
| 37 | Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial | Lancet, The | 2018 | 374 |
| 38 | Erythropoietin | New England Journal of Medicine | 1991 | 373 |
| 39 | Tyrosine Dephosphorylation and Deactivation of Insulin Receptor Substrate-1 by Protein-tyrosine Phosphatase 1B | Journal of Biological Chemistry | 2000 | 357 |
| 40 | Myocardial injury and COVID-19: Possible mechanisms | Life Sciences | 2020 | 342 |
| 41 | Inflammatory Reactions in HIV-1–Infected Persons after Initiation of Highly Active Antiretroviral Therapy | Annals of Internal Medicine | 2000 | 341 |
| 42 | Carcinoembryonic Antigen in the Staging and Follow-up of Patients with Colorectal Cancer | Cancer Investigation | 2005 | 341 |
| 43 | Sickle cell pain: a critical reappraisal | Blood | 2012 | 333 |
| 44 | Response of leptin to short-term and prolonged overfeeding in humans. | Journal of Clinical Endocrinology and Metabolism | 1996 | 329 |
| 45 | Combined Heart Failure Device Diagnostics Identify Patients at Higher Risk of Subsequent Heart Failure Hospitalizations | Journal of the American College of Cardiology | 2010 | 329 |
| 46 | Patient Perceptions of Telehealth Primary Care Video Visits | Annals of Family Medicine | 2017 | 328 |
| 47 | Intratumoral recombinant GM-CSF-encoding virus as gene therapy in patients with cutaneous melanoma | Cancer Gene Therapy | 1999 | 324 |
| 48 | Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. | Journal of Clinical Investigation | 1995 | 321 |
| 49 | Differential Expression of Lumican and Fibromodulin Regulate Collagen Fibrillogenesis in Developing Mouse Tendons | Journal of Cell Biology | 2000 | 316 |
| 50 | Prevalence of Hypovitaminosis D in Cardiovascular Diseases (from the National Health and Nutrition Examination Survey 2001 to 2004) | American Journal of Cardiology | 2008 | 314 |
