| # | Title | Journal | Year | Citations |
|---|
| 1 | Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | Nature Genetics | 2010 | 1,631 |
| 2 | Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo | Diabetes | 2006 | 469 |
| 3 | Prevalence of Drug‐Resistant HIV‐1 Variants in Untreated Individuals in Europe: Implications for Clinical Management | Journal of Infectious Diseases | 2005 | 385 |
| 4 | Vancomycin-resistant enterococci: why are they here, and where do they come from? | Lancet Infectious Diseases, The | 2001 | 353 |
| 5 | Interventions to improve the management of diabetes mellitus in primary care, outpatient and community settings | The Cochrane Library | 2000 | 282 |
| 6 | Metabolic and Additional Vascular Effects of Thiazolidinediones | Drugs | 2002 | 265 |
| 7 | Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study | BMJ: British Medical Journal | 2006 | 259 |
| 8 | Risk Factors for Ventilator‐Associated Pneumonia: From Epidemiology to Patient Management | Clinical Infectious Diseases | 2004 | 258 |
| 9 | Diabetic foot osteomyelitis: a progress report on diagnosis and a systematic review of treatment | Diabetes/Metabolism Research and Reviews | 2008 | 254 |
| 10 | Different Mechanisms for Impaired Fasting Glucose and Impaired Postprandial Glucose Tolerance in Humans | Diabetes Care | 2006 | 247 |
| 11 | Risk factors for coronary heart disease: implications of gender | Cardiovascular Research | 2002 | 227 |
| 12 | Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands | Journal of the National Cancer Institute | 2019 | 218 |
| 13 | A guide to immunotherapy for COVID-19 | Nature Medicine | 2022 | 206 |
| 14 | The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic review | Diabetes/Metabolism Research and Reviews | 2008 | 200 |
| 15 | Yttrium-90 microsphere radioembolization for the treatment of liver malignancies: a structured meta-analysis | European Radiology | 2009 | 199 |
| 16 | A systematic review of the effectiveness of interventions to enhance the healing of chronic ulcers of the foot in diabetes | Diabetes/Metabolism Research and Reviews | 2008 | 196 |
| 17 | Targeting DDX3 with a small molecule inhibitor for lung cancer therapy | EMBO Molecular Medicine | 2015 | 189 |
| 18 | Effect of Aging on Glucose Homeostasis | Diabetes Care | 2008 | 184 |
| 19 | Leukocyte Activation by Triglyceride-Rich Lipoproteins | Arteriosclerosis, Thrombosis, and Vascular Biology | 2008 | 181 |
| 20 | Accuracy of sentinel node biopsy after neoadjuvant chemotherapy in breast cancer patients: A systematic review | European Journal of Cancer | 2009 | 178 |
| 21 | Pretreatment factors predicting quality of life after treatment for head and neck cancer | Head and Neck | 2000 | 173 |
| 22 | Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm | Atherosclerosis | 2004 | 171 |
| 23 | Quality and Quantity of Sleep and Factors Associated With Sleep Disturbance in Hospitalized Patients | JAMA Internal Medicine | 2018 | 169 |
| 24 | Is the Association Between Flow-Mediated Dilation and Cardiovascular Risk Limited to Low-Risk Populations? | Journal of the American College of Cardiology | 2005 | 162 |
| 25 | Prevalence of subependymal giant cell tumors in patients with tuberous sclerosis and a review of the literature | European Journal of Neurology | 2009 | 155 |
| 26 | Hypertension and longitudinal changes in cerebral blood flow: The SMART‐MR study | Annals of Neurology | 2012 | 147 |
| 27 | The apoAI-CIII-AIV gene cluster | Atherosclerosis | 2001 | 146 |
| 28 | Outcomes of adrenal-sparing surgery or total adrenalectomy in phaeochromocytoma associated with multiple endocrine neoplasia type 2: an international retrospective population-based study | Lancet Oncology, The | 2014 | 137 |
| 29 | Patient education for preventing diabetic foot ulceration | | 2012 | 134 |
| 30 | Applicability of a Real-Time Quantitative PCR Assay for Diagnosis of Respiratory Syncytial Virus Infection in Immunocompromised Adults | Journal of Clinical Microbiology | 2003 | 132 |
| 31 | Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo | European Journal of Clinical Investigation | 2002 | 129 |
| 32 | Are Active Microbiological Surveillance and Subsequent Isolation Needed to Prevent the Spread of Methicillin-Resistant Staphylococcus aureus? | Clinical Infectious Diseases | 2005 | 127 |
| 33 | Multiple-Locus Variable-Number Tandem Repeat Analysis, a Novel Typing Scheme To Study the Genetic Relatedness and Epidemiology of Enterococcus faecium Isolates | Journal of Clinical Microbiology | 2004 | 125 |
| 34 | Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: Position statement from the Joint SHEA and APIC Task Force | American Journal of Infection Control | 2007 | 118 |
| 35 | Risk profiles and penetrance estimations in multiple endocrine neoplasia type 2A caused by germline RET mutations located in exon 10 | Human Mutation | 2011 | 117 |
| 36 | Legislative Mandates for Use of Active Surveillance Cultures to Screen for Methicillin-ResistantStaphylococcus aureusand Vancomycin-Resistant Enterococci: Position Statement From the Joint SHEA and APIC Task Force | Infection Control and Hospital Epidemiology | 2007 | 113 |
| 37 | Negative and positive influences of social support on depression in patients with head and neck cancer: a prospective study | | 2000 | 107 |
| 38 | Phenotypic heterogeneity in severe hemophilia | Journal of Thrombosis and Haemostasis | 2007 | 106 |
| 39 | The Chemokine and Chemokine Receptor Profile of Infiltrating Cells in the Wall of Arteries With Cardiac Allograft Vasculopathy Is Indicative of a Memory T–Helper 1 Response | Circulation | 2006 | 105 |
| 40 | Type 2 diabetes: pathogenesis and treatment | Lancet, The | 2008 | 103 |
| 41 | Common Cholesteryl Ester Transfer Protein Gene Polymorphisms and the Effect of Atorvastatin Therapy in Type 2 Diabetes | Diabetes Care | 2003 | 102 |
| 42 | Long-term Follow-up Assessing Renal Angiomyolipoma Treatment Patterns, Morbidity, and Mortality: An Observational Study in Tuberous Sclerosis Complex Patients in the Netherlands | American Journal of Kidney Diseases | 2015 | 98 |
| 43 | Inhibition of Human Immunodeficiency Virus Type 1 Replication in Human Mononuclear Blood Cells by the Iron Chelators Deferoxamine, Deferiprone, and Bleomycin | Journal of Infectious Diseases | 2000 | 97 |
| 44 | Multiple endocrine neoplasia type 1 (MEN1): its manifestations and effect of genetic screening on clinical outcome | Clinical Endocrinology | 2009 | 97 |
| 45 | Aggressive Lipid Lowering Does Not Improve Endothelial Function in Type 2 Diabetes: The Diabetes Atorvastatin Lipid Intervention (DALI) Study: a randomized, double-blind, placebo-controlled trial | Diabetes Care | 2002 | 93 |
| 46 | High-Level Ciprofloxacin Resistance from Point Mutations in gyrA and parC Confined to Global Hospital-Adapted Clonal Lineage CC17 of Enterococcus faecium | Journal of Clinical Microbiology | 2006 | 93 |
| 47 | Beta-lactam susceptibilities and prevalence of ESBL-producing isolates among more than 5000 European Enterobacteriaceae isolates | International Journal of Antimicrobial Agents | 2004 | 92 |
| 48 | Unresolved issues in the management of ulcers of the foot in diabetes | Diabetic Medicine | 2008 | 90 |
| 49 | Radiological evidence of lymphangioleiomyomatosis in female and male patients with tuberous sclerosis complex | Clinical Radiology | 2011 | 88 |
| 50 | Prediction of depressive symptomatology after treatment of head and neck cancer: The influence of pre-treatment physical and depressive symptoms, coping, and social support | Head and Neck | 2000 | 87 |
