| # | Title | Journal | Year | Citations |
|---|
| 1 | Symptom Prevalence in Patients with Incurable Cancer: A Systematic Review | Journal of Pain and Symptom Management | 2007 | 790 |
| 2 | Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial | Lancet Oncology, The | 2014 | 639 |
| 3 | Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery | Nature | 2008 | 596 |
| 4 | Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies | Clinical Cancer Research | 2014 | 561 |
| 5 | Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways | Cell | 2011 | 531 |
| 6 | The decision to enter mitosis: feedback and redundancy in the mitotic entry network | Journal of Cell Biology | 2009 | 516 |
| 7 | FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis | Cancer Cell | 2011 | 505 |
| 8 | An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity | Nature Medicine | 2019 | 486 |
| 9 | From tumour heterogeneity to advances in precision treatment of colorectal cancer | Nature Reviews Clinical Oncology | 2017 | 466 |
| 10 | Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer | Cancer Discovery | 2018 | 448 |
| 11 | Robot-assisted Minimally Invasive Thoracolaparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy for Resectable Esophageal Cancer | Annals of Surgery | 2019 | 436 |
| 12 | Rapid Chemotherapy-Induced Acute Endothelial Progenitor Cell Mobilization: Implications for Antiangiogenic Drugs as Chemosensitizing Agents | Cancer Cell | 2008 | 424 |
| 13 | Maintenance treatment with capecitabine and bevacizumab in metastatic colorectal cancer (CAIRO3): a phase 3 randomised controlled trial of the Dutch Colorectal Cancer Group | Lancet, The | 2015 | 421 |
| 14 | Ischemia/reperfusion accelerates the outgrowth of hepatic micrometastases in a highly standardized murine model | Hepatology | 2005 | 418 |
| 15 | Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype – phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex | European Journal of Human Genetics | 2005 | 405 |
| 16 | Palliative Sedation Therapy in the Last Weeks of Life: A Literature Review and Recommendations for Standards | Journal of Palliative Medicine | 2007 | 398 |
| 17 | The Aurora kinase family in cell division and cancer | Biochimica Et Biophysica Acta: Reviews on Cancer | 2008 | 281 |
| 18 | Limitations and possibilities of small RNA digital gene expression profiling | Nature Methods | 2009 | 280 |
| 19 | Mesenchymal Stem Cells Induce Resistance to Chemotherapy through the Release of Platinum-Induced Fatty Acids | Cancer Cell | 2011 | 279 |
| 20 | Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data | Lancet Oncology, The | 2015 | 277 |
| 21 | Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 274 |
| 22 | Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment | Cell | 2008 | 256 |
| 23 | FoxM1: At the crossroads of ageing and cancer | Biochimica Et Biophysica Acta: Reviews on Cancer | 2007 | 254 |
| 24 | Glycation Induces Formation of Amyloid Cross-β Structure in Albumin | Journal of Biological Chemistry | 2003 | 248 |
| 25 | The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis | OncoImmunology | 2017 | 247 |
| 26 | DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis | Lancet Oncology, The | 2018 | 238 |
| 27 | The outcomes of ovarian cancer treatment are better when provided by gynecologic oncologists and in specialized hospitals: A systematic review | Gynecologic Oncology | 2007 | 226 |
| 28 | Genetic analysis of von Hippel-Lindau disease | Human Mutation | 2010 | 224 |
| 29 | Temporal changes in Hec1 phosphorylation control kinetochore–microtubule attachment stability during mitosis | Journal of Cell Science | 2011 | 223 |
| 30 | Increased levels of viable circulating endothelial cells are an indicator of progressive disease in cancer patients | Annals of Oncology | 2004 | 222 |
| 31 | Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy | Cancer Discovery | 2019 | 222 |
| 32 | Tumor-Specific Uptake of Fluorescent Bevacizumab–IRDye800CW Microdosing in Patients with Primary Breast Cancer: A Phase I Feasibility Study | Clinical Cancer Research | 2017 | 212 |
| 33 | Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery | Current Biology | 2006 | 205 |
| 34 | Target Practice: Lessons from Phase III Trials with Bevacizumab and Vatalanib in the Treatment of Advanced Colorectal Cancer | Oncologist | 2007 | 203 |
| 35 | Receptor Conversion in Distant Breast Cancer Metastases: A Systematic Review and Meta-analysis | Journal of the National Cancer Institute | 2018 | 198 |
| 36 | Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis | Nature Communications | 2011 | 193 |
| 37 | Negative feedback at kinetochores underlies a responsive spindle checkpoint signal | Nature Cell Biology | 2014 | 181 |
| 38 | Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer | Genome Biology | 2011 | 177 |
| 39 | Functional aspects of primary cilia in signaling, cell cycle and tumorigenesis | Cilia | 2013 | 177 |
| 40 | Low skeletal muscle mass is a predictive factor for chemotherapy dose-limiting toxicity in patients with locally advanced head and neck cancer | Oral Oncology | 2017 | 172 |
| 41 | Dabrafenib plus trametinib in patients with BRAFV600E-mutant low-grade and high-grade glioma (ROAR): a multicentre, open-label, single-arm, phase 2, basket trial | Lancet Oncology, The | 2022 | 165 |
| 42 | The case for Survivin as mitotic regulator | Current Opinion in Cell Biology | 2006 | 161 |
| 43 | Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease | Journal of Cell Biology | 2011 | 159 |
| 44 | Prognostic Value of Resection of Primary Tumor in Patients with Stage IV Colorectal Cancer: Retrospective Analysis of Two Randomized Studies and a Review of the Literature | Annals of Surgical Oncology | 2011 | 158 |
| 45 | Outcomes of colorectal cancer patients with peritoneal carcinomatosis treated with chemotherapy with and without targeted therapy | European Journal of Surgical Oncology | 2012 | 156 |
| 46 | Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses | Cell Reports | 2020 | 155 |
| 47 | Robot-assisted minimally invasive thoraco-laparoscopic esophagectomy versus open transthoracic esophagectomy for resectable esophageal cancer, a randomized controlled trial (ROBOT trial) | Trials | 2012 | 152 |
| 48 | The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs | Nature | 2019 | 152 |
| 49 | Chemotherapy Enhances Metastasis Formation via VEGFR-1–Expressing Endothelial Cells | Cancer Research | 2011 | 146 |
| 50 | Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly | EMBO Journal | 2008 | 144 |
