| # | Title | Journal | Year | Citations |
|---|
| 1 | Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium | Gastroenterology | 2011 | 2,835 |
| 2 | Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2017 | 831 |
| 3 | Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease | Gut | 2011 | 612 |
| 4 | Detectable clonal mosaicism and its relationship to aging and cancer | Nature Genetics | 2012 | 519 |
| 5 | Population-based epidemiology, malignancy risk, and outcome of primary sclerosing cholangitis | Hepatology | 2013 | 519 |
| 6 | Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial | Lancet, The | 2018 | 504 |
| 7 | Robot-assisted Minimally Invasive Thoracolaparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy for Resectable Esophageal Cancer | Annals of Surgery | 2019 | 436 |
| 8 | Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study | Gut | 2014 | 430 |
| 9 | Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis | Science Translational Medicine | 2016 | 428 |
| 10 | Declining Risk of Colorectal Cancer in Inflammatory Bowel Disease | Inflammatory Bowel Diseases | 2013 | 391 |
| 11 | Improved Prognosis of Patients With Primary Biliary Cirrhosis That Have a Biochemical Response to Ursodeoxycholic Acid | Gastroenterology | 2009 | 387 |
| 12 | Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus | Gastroenterology | 2010 | 345 |
| 13 | High lifetime risk of cancer in primary sclerosing cholangitis | Journal of Hepatology | 2009 | 334 |
| 14 | Local recurrence after endoscopic mucosal resection of nonpedunculated colorectal lesions: systematic review and meta-analysis | Endoscopy | 2014 | 305 |
| 15 | Factors influencing the miss rate of polyps in a back-to-back colonoscopy study | Endoscopy | 2012 | 277 |
| 16 | Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1 | Gastroenterology | 2014 | 268 |
| 17 | International multicenter experience with an over-the-scope clipping device for endoscopic management of GI defects (with video) | Gastrointestinal Endoscopy | 2014 | 255 |
| 18 | Systematic review: temporary stent placement for benign rupture or anastomotic leak of the oesophagus | Alimentary Pharmacology and Therapeutics | 2011 | 238 |
| 19 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial | Lancet Oncology, The | 2014 | 220 |
| 20 | Adalimumab combined with ciprofloxacin is superior to adalimumab monotherapy in perianal fistula closure in Crohn's disease: a randomised, double-blind, placebo controlled trial (ADAFI) | Gut | 2014 | 195 |
| 21 | EUS-guided gall bladder drainage with a lumen-apposing metal stent: a prospective long-term evaluation | Gut | 2016 | 191 |
| 22 | Relapse is almost universal after withdrawal of immunosuppressive medication in patients with autoimmune hepatitis in remission | Journal of Hepatology | 2013 | 182 |
| 23 | Treatment options for esophageal strictures | Nature Reviews Gastroenterology & Hepatology | 2008 | 180 |
| 24 | Protein energy malnutrition predicts complications in liver cirrhosis | European Journal of Gastroenterology and Hepatology | 2011 | 170 |
| 25 | Intrahepatic cholestasis of pregnancy: maternal and fetal outcomes associated with elevated bile acid levels | American Journal of Obstetrics and Gynecology | 2015 | 164 |
| 26 | Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohort | Gut | 2009 | 162 |
| 27 | Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus | Nature Genetics | 2012 | 162 |
| 28 | IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes | Nature Communications | 2018 | 159 |
| 29 | Serum immunoglobulin G4 and immunoglobulin G1 for distinguishing immunoglobulin G4‐associated cholangitis from primary sclerosing cholangitis | Hepatology | 2014 | 158 |
| 30 | Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands | Scandinavian Journal of Gastroenterology | 2014 | 153 |
| 31 | Human gastrointestinal epithelia of the esophagus, stomach, and duodenum resolved at single-cell resolution | Cell Reports | 2021 | 153 |
| 32 | Metal or plastic stents for preoperative biliary drainage in resectable pancreatic cancer | Gut | 2016 | 147 |
| 33 | Location in the Right Hemi-Colon Is an Independent Risk Factor for Delayed Post-Polypectomy Hemorrhage: A Multi-Center Case–Control Study | American Journal of Gastroenterology | 2011 | 145 |
| 34 | Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine | Biochimica Et Biophysica Acta - Molecular Basis of Disease | 2011 | 138 |
| 35 | Gastroesophageal Pressure Gradients in Gastroesophageal Reflux Disease: Relations With Hiatal Hernia, Body Mass Index, and Esophageal Acid Exposure | American Journal of Gastroenterology | 2008 | 136 |
| 36 | Surveillance of Barrett's Esophagus and Mortality from Esophageal Adenocarcinoma: A Population-Based Cohort Study | American Journal of Gastroenterology | 2014 | 135 |
| 37 | Thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease | Gut | 2012 | 132 |
| 38 | Plastic or metal stents for benign extrahepatic biliary strictures: a systematic review | BMC Gastroenterology | 2009 | 130 |
| 39 | Effect of Sleeve Gastrectomy on Gastroesophageal Reflux | Obesity Surgery | 2014 | 128 |
| 40 | Systematic review: the effects of conservative and surgical treatment for obesity on gastro‐oesophageal reflux disease | Alimentary Pharmacology and Therapeutics | 2009 | 127 |
| 41 | Ustekinumab for Crohn’s Disease: Results of the ICC Registry, a Nationwide Prospective Observational Cohort Study | Journal of Crohn's and Colitis | 2020 | 124 |
| 42 | Oncologic Long-Term Results of Robot-Assisted Minimally Invasive Thoraco-Laparoscopic Esophagectomy with Two-Field Lymphadenectomy for Esophageal Cancer | Annals of Surgical Oncology | 2015 | 123 |
| 43 | Pathogenesis of Gallstones | Gastroenterology Clinics of North America | 2010 | 120 |
| 44 | Cost Efficacy of Metal Stents for Palliation of Extrahepatic Bile Duct Obstruction in a Randomized Controlled Trial | Gastroenterology | 2015 | 118 |
| 45 | Surveillance for hepatocellular carcinoma is associated with increased survival: Results from a large cohort in the Netherlands | Journal of Hepatology | 2015 | 117 |
| 46 | Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease | Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids | 2010 | 115 |
| 47 | Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands | European Journal of Cancer | 2012 | 113 |
| 48 | Determinants of health-related quality of life in Crohn's disease: A systematic review and meta-analysis | Journal of Crohn's and Colitis | 2014 | 113 |
| 49 | Prognostic Factors for Advanced Colorectal Neoplasia in Inflammatory Bowel Disease: Systematic Review and Meta-analysis | Gastroenterology | 2021 | 113 |
| 50 | Social Inequalities and Mortality in Europe – Results from a Large Multi-National Cohort | PLoS ONE | 2012 | 113 |
