| # | Title | Journal | Year | Citations |
|---|
| 1 | Prediction models for diagnosis and prognosis of covid-19: systematic review and critical appraisal | BMJ, The | 2020 | 2,134 |
| 2 | Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study | Lancet, The | 2012 | 1,937 |
| 3 | STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies | BMJ, The | 2015 | 1,914 |
| 4 | Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis | Lancet Infectious Diseases, The | 2019 | 1,908 |
| 5 | Review: A gentle introduction to imputation of missing values | Journal of Clinical Epidemiology | 2006 | 1,900 |
| 6 | Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement | BMJ, The | 2015 | 1,842 |
| 7 | Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies | JAMA - Journal of the American Medical Association | 2018 | 1,783 |
| 8 | Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19) | Intensive Care Medicine | 2020 | 1,536 |
| 9 | Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable | Medicine and Science in Sports and Exercise | 2019 | 1,443 |
| 10 | STARD 2015 guidelines for reporting diagnostic accuracy studies: explanation and elaboration | BMJ Open | 2016 | 1,324 |
| 11 | Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD Statement | BMC Medicine | 2015 | 1,273 |
| 12 | The Impact of Critical Illness on Perceived Health-Related Quality of Life During ICU Treatment, Hospital Stay, and After Hospital Discharge | Chest | 2008 | 1,260 |
| 13 | Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials | Lancet, The | 2010 | 1,168 |
| 14 | Genome-wide association study identifies eight loci associated with blood pressure | Nature Genetics | 2009 | 1,104 |
| 15 | Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modelling Studies: The CHARMS Checklist | PLoS Medicine | 2014 | 1,036 |
| 16 | Prognosis Research Strategy (PROGRESS) 3: Prognostic Model Research | PLoS Medicine | 2013 | 1,006 |
| 17 | Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies | Lancet Neurology, The | 2014 | 980 |
| 18 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 19 | Epidemiology of heart failure | European Journal of Heart Failure | 2020 | 948 |
| 20 | How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) | European Heart Journal | 2019 | 944 |
| 21 | Methicillin-resistant Staphylococcus aureus | Nature Reviews Disease Primers | 2018 | 833 |
| 22 | Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis | Diabetologia | 2006 | 815 |
| 23 | Recommendations for presenting analyses of effect modification and interaction | International Journal of Epidemiology | 2012 | 800 |
| 24 | Increased Risk of Common Infections in Patients with Type 1 and Type 2 Diabetes Mellitus | Clinical Infectious Diseases | 2005 | 785 |
| 25 | Rapid, point-of-care antigen and molecular-based tests for diagnosis of SARS-CoV-2 infection | The Cochrane Library | 2020 | 770 |
| 26 | Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): The TRIPOD statement | British Journal of Cancer | 2015 | 752 |
| 27 | Guidelines for the management of adult lower respiratory tract infections - Full version | Clinical Microbiology and Infection | 2011 | 721 |
| 28 | Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19 | JAMA - Journal of the American Medical Association | 2020 | 671 |
| 29 | The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm | Nature Genetics | 2008 | 668 |
| 30 | Risk prediction models: I. Development, internal validation, and assessing the incremental value of a new (bio)marker | Heart | 2012 | 666 |
| 31 | Antibody tests for identification of current and past infection with SARS-CoV-2 | The Cochrane Library | 2020 | 664 |
| 32 | Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis | Menopause | 2006 | 597 |
| 33 | Exercise training in heart failure: from theory to practice. A consensus document of the Heart Failure Association and the European Association for Cardiovascular Prevention and Rehabilitation | European Journal of Heart Failure | 2011 | 580 |
| 34 | New WHO recommendations on preoperative measures for surgical site infection prevention: an evidence-based global perspective | Lancet Infectious Diseases, The | 2016 | 570 |
| 35 | Mendelian randomization of blood lipids for coronary heart disease | European Heart Journal | 2015 | 567 |
| 36 | HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials | Lancet, The | 2015 | 562 |
| 37 | Prognosis Research Strategy (PROGRESS) 2: Prognostic Factor Research | PLoS Medicine | 2013 | 561 |
| 38 | Rare and low-frequency coding variants alter human adult height | Nature | 2017 | 544 |
| 39 | Prediction models for cardiovascular disease risk in the general population: systematic review | BMJ, The | 2016 | 543 |
| 40 | Definitions in hemophilia: communication from the SSC of the ISTH | Journal of Thrombosis and Haemostasis | 2014 | 530 |
| 41 | Mortality in adult congenital heart disease | European Heart Journal | 2010 | 518 |
| 42 | Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events | Diabetologia | 2014 | 485 |
| 43 | External validation of multivariable prediction models: a systematic review of methodological conduct and reporting | BMC Medical Research Methodology | 2014 | 483 |
| 44 | Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection | The Cochrane Library | 2022 | 482 |
| 45 | Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project | BMJ, The | 2014 | 481 |
| 46 | 89Zr-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer | Nature Medicine | 2018 | 468 |
| 47 | The five-factor model of the Positive and Negative Syndrome Scale II: A ten-fold cross-validation of a revised model | Schizophrenia Research | 2006 | 466 |
| 48 | Missing covariate data in medical research: To impute is better than to ignore | Journal of Clinical Epidemiology | 2010 | 458 |
| 49 | Prognosis research strategy (PROGRESS) 1: A framework for researching clinical outcomes | BMJ, The | 2013 | 450 |
| 50 | STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies | Clinical Chemistry | 2015 | 449 |
