| # | Title | Journal | Year | Citations |
|---|
| 1 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
| 2 | A Single-Cell Transcriptome Atlas of the Human Pancreas | Cell Systems | 2016 | 966 |
| 3 | Multi-ethnic genome-wide association study for atrial fibrillation | Nature Genetics | 2018 | 552 |
| 4 | A catalog of genetic loci associated with kidney function from analyses of a million individuals | Nature Genetics | 2019 | 549 |
| 5 | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function | Nature Communications | 2018 | 484 |
| 6 | Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk | Nature Genetics | 2017 | 426 |
| 7 | The power of genetic diversity in genome-wide association studies of lipids | Nature | 2021 | 353 |
| 8 | The trans-ancestral genomic architecture of glycemic traits | Nature Genetics | 2021 | 341 |
| 9 | Complete Remission of Accelerated Phase Chronic Myeloid Leukemia by Treatment With Leukemia-Reactive Cytotoxic T Lymphocytes | Blood | 1999 | 260 |
| 10 | Effectiveness of discontinuing antibiotic treatment after three days versus eight days in mild to moderate-severe community acquired pneumonia: randomised, double blind study | BMJ: British Medical Journal | 2006 | 259 |
| 11 | Insulin Resistance and Risk of Incident Cardiovascular Events in Adults without Diabetes: Meta-Analysis | PLoS ONE | 2012 | 256 |
| 12 | Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?) | Nature Reviews Endocrinology | 2021 | 256 |
| 13 | Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels | Nature Genetics | 2019 | 251 |
| 14 | Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation | Nature Genetics | 2022 | 250 |
| 15 | Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited | Aging Cell | 2011 | 249 |
| 16 | THERAPY OF ENDOCRINE DISEASE: Hungry bone syndrome: still a challenge in the post-operative management of primary hyperparathyroidism: a systematic review of the literature | European Journal of Endocrinology | 2013 | 248 |
| 17 | ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease | Blood Advances | 2021 | 246 |
| 18 | Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis | Nature Human Behaviour | 2021 | 193 |
| 19 | A high response is not essential to prevent selection bias | Journal of Clinical Epidemiology | 2002 | 188 |
| 20 | Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients | Transfusion | 2006 | 188 |
| 21 | A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals | Nature Communications | 2019 | 188 |
| 22 | Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study | Lancet, The | 2002 | 186 |
| 23 | Genetic insights into biological mechanisms governing human ovarian ageing | Nature | 2021 | 183 |
| 24 | Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes | Nature Medicine | 2017 | 182 |
| 25 | Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation | Nature Communications | 2018 | 181 |
| 26 | Necessity of the assessment of health status in human immunogerontological studies: Evaluation of the senieur protocol | Mechanisms of Ageing and Development | 1990 | 175 |
| 27 | Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation | Frontiers in Neuroendocrinology | 2018 | 175 |
| 28 | Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: Results of genome-wide association analyses including 4659 European individuals | Atherosclerosis | 2010 | 146 |
| 29 | Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles | Nature Genetics | 2022 | 135 |
| 30 | Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria | Nature Communications | 2019 | 133 |
| 31 | An EMT‐related gene signature for the prognosis of human bladder cancer | Journal of Cellular and Molecular Medicine | 2020 | 132 |
| 32 | Positively selected enhancer elements endow osteosarcoma cells with metastatic competence | Nature Medicine | 2018 | 126 |
| 33 | Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments | American Journal of Clinical Nutrition | 2018 | 126 |
| 34 | COVID-19 and Diabetes: Understanding the Interrelationship and Risks for a Severe Course | Frontiers in Endocrinology | 2021 | 124 |
| 35 | A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure | American Journal of Human Genetics | 2018 | 123 |
| 36 | How to: Establish and run a stool bank | Clinical Microbiology and Infection | 2017 | 120 |
| 37 | GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes | Nature Communications | 2018 | 119 |
| 38 | Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity | Nature Communications | 2017 | 118 |
| 39 | Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length | American Journal of Human Genetics | 2020 | 118 |
| 40 | Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation | Journal of the American Society of Nephrology: JASN | 2020 | 117 |
| 41 | Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis | American Journal of Human Genetics | 2017 | 112 |
| 42 | Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis | Journal of Neuroimmunology | 2002 | 111 |
| 43 | Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential | Stem Cell Reports | 2018 | 106 |
| 44 | Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits | American Journal of Human Genetics | 2019 | 106 |
| 45 | Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease | Nature Reviews Nephrology | 2017 | 104 |
| 46 | Zoledronate for the Prevention of Bone Loss in Women Discontinuing Denosumab Treatment. A Prospective 2-Year Clinical Trial | Journal of Bone and Mineral Research | 2019 | 103 |
| 47 | EULAR recommendations for the management of ANCA-associated vasculitis: 2022 update | Annals of the Rheumatic Diseases | 2024 | 101 |
| 48 | Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin | Diabetes | 2004 | 97 |
| 49 | Quality of life (QoL) impairments in patients with a pituitary adenoma: a systematic review of QoL studies | Pituitary | 2015 | 95 |
| 50 | Endothelial Function in Patients with Hyperthyroidism Before and After Treatment with Propranolol and Thiamazol | Thyroid | 2001 | 94 |
