| # | Title | Journal | Year | Citations |
|---|
| 1 | Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936 | Leukemia | 2003 | 2,788 |
| 2 | Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial | Lancet, The | 2004 | 1,561 |
| 3 | Mutations in SDHD , a Mitochondrial Complex II Gene, in Hereditary Paraganglioma | Science | 2000 | 1,554 |
| 4 | 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus | Annals of the Rheumatic Diseases | 2019 | 1,265 |
| 5 | Pathologic Classification of Diabetic Nephropathy | Journal of the American Society of Nephrology: JASN | 2010 | 1,191 |
| 6 | Association analysis identifies 65 new breast cancer risk loci | Nature | 2017 | 1,099 |
| 7 | The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms | Leukemia | 2022 | 1,023 |
| 8 | Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial | Lancet, The | 2010 | 985 |
| 9 | Randomized Trial of Plasma Exchange or High-Dosage Methylprednisolone as Adjunctive Therapy for Severe Renal Vasculitis | Journal of the American Society of Nephrology: JASN | 2007 | 973 |
| 10 | EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis | Annals of the Rheumatic Diseases | 2016 | 940 |
| 11 | Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis | Annals of the Rheumatic Diseases | 2012 | 868 |
| 12 | ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up | Annals of Oncology | 2016 | 862 |
| 13 | ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma | International Journal of Gynecological Cancer | 2021 | 859 |
| 14 | Macroscopic Evaluation of Rectal Cancer Resection Specimen: Clinical Significance of the Pathologist in Quality Control | Journal of Clinical Oncology | 2002 | 822 |
| 15 | Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data | Genome Medicine | 2019 | 732 |
| 16 | Circumferential Margin Involvement Is Still an Important Predictor of Local Recurrence in Rectal Carcinoma | American Journal of Surgical Pathology | 2002 | 699 |
| 17 | HRPT2, encoding parafibromin, is mutated in hyperparathyroidism–jaw tumor syndrome | Nature Genetics | 2002 | 686 |
| 18 | Histopathologic Classification of ANCA-Associated Glomerulonephritis | Journal of the American Society of Nephrology: JASN | 2010 | 681 |
| 19 | Pathologic classification of focal segmental glomerulosclerosis: a working proposal | American Journal of Kidney Diseases | 2004 | 654 |
| 20 | Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2018 | 641 |
| 21 | Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases | Blood | 2008 | 617 |
| 22 | ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach | Annals of Oncology | 2019 | 614 |
| 23 | Sarcoma Derived from Cultured Mesenchymal Stem Cells | Stem Cells | 2007 | 601 |
| 24 | Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors | Nature Communications | 2018 | 578 |
| 25 | Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance | Gastroenterology | 2004 | 536 |
| 26 | Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts | Clinical Cancer Research | 2016 | 535 |
| 27 | Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices | Kidney International | 2018 | 532 |
| 28 | ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: Diagnosis, Treatment and Follow-up | International Journal of Gynecological Cancer | 2016 | 515 |
| 29 | Microparticle‐associated tissue factor activity: a link between cancer and thrombosis? | Journal of Thrombosis and Haemostasis | 2007 | 506 |
| 30 | C3 glomerulopathy: consensus report | Kidney International | 2013 | 505 |
| 31 | Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome | Nature Genetics | 2011 | 488 |
| 32 | An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity | Nature Medicine | 2019 | 486 |
| 33 | The biology of the 17–1A antigen (Ep-CAM) | Journal of Molecular Medicine | 1999 | 466 |
| 34 | 2019 Update of the Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA–EDTA) recommendations for the management of lupus nephritis | Annals of the Rheumatic Diseases | 2020 | 463 |
| 35 | A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy | Molecular Cell | 1998 | 445 |
| 36 | Lymphatic and Other Vascular Malformative/Overgrowth Disorders Are Caused by Somatic Mutations in PIK3CA | Journal of Pediatrics | 2015 | 429 |
| 37 | Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk | Nature Genetics | 2017 | 426 |
| 38 | Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial | Lancet Oncology, The | 2018 | 426 |
| 39 | BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients | Nature Genetics | 1997 | 414 |
| 40 | Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2018 | 413 |
| 41 | Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy | Journal of Clinical Oncology | 2020 | 398 |
| 42 | EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer | Cell | 2003 | 389 |
| 43 | Neoantigen landscape dynamics during human melanoma–T cell interactions | Nature | 2016 | 387 |
| 44 | Chemotherapeutic adjuvant treatment for osteosarcoma: Where do we stand? | European Journal of Cancer | 2011 | 386 |
| 45 | Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆ | Annals of Oncology | 2021 | 381 |
| 46 | Bone sarcomas: ESMO–PaedCan–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up | Annals of Oncology | 2018 | 380 |
| 47 | A systematic review of pathological findings in COVID-19: a pathophysiological timeline and possible mechanisms of disease progression | Modern Pathology | 2020 | 378 |
| 48 | Fatty kidney: emerging role of ectopic lipid in obesity-related renal disease | Lancet Diabetes and Endocrinology,the | 2014 | 355 |
| 49 | Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a TransPORTEC initiative | Modern Pathology | 2015 | 343 |
| 50 | E-cadherin inactivation in lobular carcinoma in situ of the breast: an early event in tumorigenesis | British Journal of Cancer | 1997 | 335 |
