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Top Articles

#TitleJournalYearCitations
1Genetics of rheumatoid arthritis contributes to biology and drug discoveryNature20141,974
2Pharmacogenetics: From Bench to Byte— An Update of GuidelinesClinical Pharmacology and Therapeutics2011869
3Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus DosingClinical Pharmacology and Therapeutics2015491
4Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 updateClinical Pharmacology and Therapeutics2017450
5Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 UpdateClinical Pharmacology and Therapeutics2018407
6Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Tricyclic AntidepressantsClinical Pharmacology and Therapeutics2013397
7Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working GroupClinical and Translational Science2020353
8Arsenic neurotoxicity — A reviewHuman and Experimental Toxicology2007331
9Cardiotoxicity of cytotoxic drugsCancer Treatment Reviews2004318
10Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine DosingClinical Pharmacology and Therapeutics2013298
11Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritisRheumatology2007274
12Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen TherapyClinical Pharmacology and Therapeutics2018244
13Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics ConsortiumClinical Pharmacology and Therapeutics2017240
14DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysisLancet Oncology, The2018238
15CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responsesBiomaterials2015235
16Pharmacogenetics: From Bench to ByteClinical Pharmacology and Therapeutics2008229
17Clinical Pharmacokinetics and Pharmacodynamics of Immune Checkpoint InhibitorsClinical Pharmacokinetics2019222
18Pharmacokinetics/Pharmacodynamics of BisphosphonatesClinical Pharmacokinetics2005198
19Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working GroupClinical Pharmacology and Therapeutics2018186
20Translating Pharmacogenomics: Challenges on the Road to the ClinicPLoS Medicine2007174
21Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel DiseaseGastroenterology2015169
22HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trialJournal of Translational Medicine2013165
23Pharmacology of oxaliplatin and the use of pharmacogenomics to individualize therapyCancer Treatment Reviews2005161
24Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T‐cell activationEuropean Journal of Immunology2013157
25Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic applicationPeptides2006155
26Effect of Concomitant CYP2D6 Inhibitor Use and Tamoxifen Adherence on Breast Cancer Recurrence in Early-Stage Breast CancerJournal of Clinical Oncology2010150
27Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid ArthritisPLoS Genetics2013146
28Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell ResponseClinical Cancer Research2016132
29Immunization with a P53 synthetic long peptide vaccine induces P53‐specific immune responses in ovarian cancer patients, a phase II trialInternational Journal of Cancer2009123
30Explaining Variability in Tacrolimus Pharmacokinetics to Optimize Early Exposure in Adult Kidney Transplant RecipientsTherapeutic Drug Monitoring2009119
31Exhaled Nitric Oxide (NO) Is Reduced Shortly after Bronchoconstriction to Direct and Indirect Stimuli in AsthmaAmerican Journal of Respiratory and Critical Care Medicine1998118
32Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of IrinotecanClinical Cancer Research2005115
33Prospective DPYD genotyping to reduce the risk of fluoropyrimidine-induced severe toxicity: Ready for prime timeEuropean Journal of Cancer2016110
34Poly-(lactic-co-glycolic-acid)-based particulate vaccines: Particle uptake by dendritic cells is a key parameter for immune activationVaccine2015109
35Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of ImatinibClinical Cancer Research2007107
36Hormonal and reproductive factors in relation to melanoma in women: Current review and meta-analysisEuropean Journal of Cancer2011106
37Sirolimus and everolimus in kidney transplantationDrug Discovery Today2015101
38Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic reviewCancer Treatment Reviews2015101
39Mitotane has a strong and a durable inducing effect on CYP3A4 activityEuropean Journal of Endocrinology201199
40A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnosticsNature Medicine202097
41Optimization of encapsulation of a synthetic long peptide in PLGA nanoparticles: Low-burst release is crucial for efficient CD8+ T cell activationEuropean Journal of Pharmaceutics and Biopharmaceutics201395
42SERIES: eHealth in primary care. Part 1: Concepts, conditions and challengesEuropean Journal of General Practice201992
43Activation of Tumor-Promoting Type 2 Macrophages by EGFR-Targeting Antibody CetuximabClinical Cancer Research201191
44A Review of Mathematical Models for Tumor Dynamics and Treatment Resistance Evolution of Solid TumorsCPT: Pharmacometrics and Systems Pharmacology201990
45Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical ToxicologyTherapeutic Drug Monitoring202189
46Intrathecal baclofen for dystonia of complex regional pain syndromePain200988
47Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic dataEuropean Heart Journal201186
48Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A ReviewOncologist201185
49Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modellingBritish Journal of Clinical Pharmacology200582
50Clinical and pharmacogenetic factors associated with irinotecan toxicityCancer Treatment Reviews200882