| # | Title | Journal | Year | Citations |
|---|
| 1 | Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial | Lancet, The | 2002 | 2,333 |
| 2 | Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target | American Journal of Gastroenterology | 2015 | 1,425 |
| 3 | Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial | Lancet, The | 2016 | 771 |
| 4 | Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease | Gut | 2009 | 574 |
| 5 | Accuracy of Revised Bethesda Guidelines, Microsatellite Instability, and Immunohistochemistry for the Identification of Patients With Hereditary Nonpolyposis Colorectal Cancer | JAMA - Journal of the American Medical Association | 2005 | 457 |
| 6 | Identification of Lynch Syndrome Among Patients With Colorectal Cancer | JAMA - Journal of the American Medical Association | 2012 | 443 |
| 7 | ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1 | Oncogene | 2010 | 406 |
| 8 | β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 375 |
| 9 | Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn’s Disease | Gastroenterology | 2018 | 331 |
| 10 | Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline | Endoscopy | 2014 | 315 |
| 11 | Accuracy of Magnetic Resonance Enterography in Assessing Response to Therapy and Mucosal Healing in Patients With Crohn's Disease | Gastroenterology | 2014 | 313 |
| 12 | Short-term outcome analysis of a randomized study comparing laparoscopic vs open colectomy for colon cancer | Surgical Endoscopy and Other Interventional Techniques | 1995 | 310 |
| 13 | Transanal Total Mesorectal Excision for Rectal Cancer: Outcomes after 140 Patients | Journal of the American College of Surgeons | 2015 | 292 |
| 14 | Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline | Endoscopy | 2011 | 279 |
| 15 | Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas) | Gut | 2016 | 274 |
| 16 | Indications, results, and clinical impact of endoscopic ultrasound (EUS)-guided sampling in gastroenterology: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline – Updated January 2017 | Endoscopy | 2017 | 270 |
| 17 | Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer | Proceedings of the National Academy of Sciences of the United States of America | 2006 | 240 |
| 18 | Port site metastases and recurrence after laparoscopic colectomy | Surgical Endoscopy and Other Interventional Techniques | 1998 | 223 |
| 19 | Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2019 | Endoscopy | 2019 | 217 |
| 20 | Increased Response and Remission Rates in Short-Duration Crohn's Disease With Subcutaneous Certolizumab Pegol: An Analysis of PRECiSE 2 Randomized Maintenance Trial Data | American Journal of Gastroenterology | 2010 | 201 |
| 21 | The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status | European Journal of Cancer | 2009 | 179 |
| 22 | VCAM-1, but Not ICAM-1 or MAdCAM-1, Immunoblockade Ameliorates DSS-Induced Colitis in Mice | Laboratory Investigation | 2000 | 172 |
| 23 | Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor–induced P-selectin up-regulation in the rat | Hepatology | 2001 | 168 |
| 24 | A High Degree of LINE-1 Hypomethylation Is a Unique Feature of Early-Onset Colorectal Cancer | PLoS ONE | 2012 | 164 |
| 25 | Crohn??s Disease Patients Carrying Nod2/CARD15 Gene Variants Have an Increased and Early Need for First Surgery due to Stricturing Disease and Higher Rate of Surgical Recurrence | Annals of Surgery | 2005 | 163 |
| 26 | TNF-α Blockade Down-Regulates the CD40/CD40L Pathway in the Mucosal Microcirculation: A Novel Anti-Inflammatory Mechanism of Infliximab in Crohn’s Disease | Journal of Immunology | 2006 | 151 |
| 27 | Percutaneous Self-expanding Metal Stents versus Endoscopic Polyethylene Endoprostheses for Treating Malignant Biliary Obstruction: Randomized Clinical Trial | Radiology | 2002 | 147 |
| 28 | Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine | Journal of Leukocyte Biology | 2004 | 141 |
| 29 | Detection of BRAF V600E Mutation in Colorectal Cancer | Journal of Molecular Diagnostics | 2006 | 136 |
| 30 | Curcumin Modulates DNA Methylation in Colorectal Cancer Cells | PLoS ONE | 2013 | 135 |
| 31 | The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study | Gut | 2011 | 128 |
| 32 | Postoperative complications of laparoscopic-assisted colectomy | Surgical Endoscopy and Other Interventional Techniques | 1997 | 125 |
| 33 | Clinical patterns and outcomes of ischaemic colitis: Results of the Working Group for the Study of Ischaemic Colitis in Spain (CIE study) | Scandinavian Journal of Gastroenterology | 2011 | 124 |
| 34 | The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression | Nature Cell Biology | 2014 | 115 |
| 35 | The genetic basis of familial adenomatous polyposis and its implications for clinical practice and risk management | The Application of Clinical Genetics | 2015 | 100 |
| 36 | Clinical management of hereditary colorectal cancer syndromes | Nature Reviews Gastroenterology and Hepatology | 2015 | 99 |
| 37 | Development of the Paris Definition of Early Crohn's Disease for Disease-Modification Trials: Results of an International Expert Opinion Process | American Journal of Gastroenterology | 2012 | 93 |
| 38 | Colorectal cancer risk factors in patients with serrated polyposis syndrome: a large multicentre study | Gut | 2016 | 93 |
| 39 | Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease | Gut | 2005 | 91 |
| 40 | EUS and magnetic resonance imaging in the staging of rectal cancer: a prospective and comparative study | Gastrointestinal Endoscopy | 2011 | 90 |
| 41 | Polyp Morphology: An Interobserver Evaluation for the Paris Classification Among International Experts | American Journal of Gastroenterology | 2015 | 86 |
| 42 | A Prospective, Multicenter, Population-Based Study of BRAF Mutational Analysis for Lynch Syndrome Screening | Clinical Gastroenterology and Hepatology | 2008 | 85 |
| 43 | Epidemiological risk factors in microscopic colitis: a prospective case-control study | Inflammatory Bowel Diseases | 2013 | 80 |
| 44 | Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation | International Journal of Radiation Oncology Biology Physics | 2003 | 76 |
| 45 | Commensal-Specific CD4+ Cells From Patients With Crohn’s Disease Have a T-Helper 17 Inflammatory Profile | Gastroenterology | 2016 | 75 |
| 46 | Differential Expression of cdc25 Cell-Cycle–Activating Phosphatases in Human Colorectal Carcinoma | Laboratory Investigation | 2001 | 74 |
| 47 | The European Panel on the Appropriateness of Gastrointestinal Endoscopy guidelines colonoscopy in an open-access endoscopy unit: a prospective study | Alimentary Pharmacology and Therapeutics | 2005 | 71 |
| 48 | Lack of prognostic influence of circulating tumor cells in peripheral blood of patients with colorectal cancer | Gastroenterology | 2001 | 70 |
| 49 | Hydrocolonic Sonography for Evaluating Inflammatory Bowel Disease | American Journal of Roentgenology | 2001 | 70 |
| 50 | Incidence, Clinical Characteristics, and Management of Psoriasis Induced by Anti-TNF Therapy in Patients with Inflammatory Bowel Disease | Inflammatory Bowel Diseases | 2016 | 70 |
