# | Title | Journal | Year | Citations |
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1 | Predicting new molecular targets for known drugs | Nature | 2009 | 1,474 |
2 | Structure of the human κ-opioid receptor in complex with JDTic | Nature | 2012 | 797 |
3 | A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior | Neuron | 2015 | 320 |
4 | An electrotopological-state index for atoms in molecules | Pharmaceutical Research | 1990 | 319 |
5 | Amino acid side chain parameters for correlation studies in biology and pharmacology | International Journal of Peptide and Protein Research | 1988 | 319 |
6 | Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens | Psychopharmacology | 1988 | 308 |
7 | HINT: A new method of empirical hydrophobic field calculation for CoMFA | Journal of Computer-Aided Molecular Design | 1991 | 303 |
8 | A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse | Journal of Cardiovascular Pharmacology | 2014 | 215 |
9 | 5-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells | British Journal of Haematology | 2005 | 211 |
10 | Improved Multilocus Sequence Typing Scheme for Staphylococcus epidermidis | Journal of Clinical Microbiology | 2007 | 207 |
11 | A Shape Index from Molecular Graphs | QSAR and Combinatorial Science | 1985 | 192 |
12 | Serotonin receptors: Clinical implications | Neuroscience and Biobehavioral Reviews | 1990 | 189 |
13 | Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptors | Drug and Alcohol Dependence | 2000 | 182 |
14 | Vitamin B6 salvage enzymes: Mechanism, structure and regulation | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2011 | 178 |
15 | NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) | European Journal of Pharmacology | 1988 | 174 |
16 | Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse | International Journal of Cardiology | 2016 | 173 |
17 | Modeling Blood-Brain Barrier Partitioning Using the Electrotopological State | Journal of Chemical Information and Computer Sciences | 2002 | 167 |
18 | Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia | Nature Communications | 2016 | 163 |
19 | Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation | International Journal of Molecular Sciences | 2019 | 159 |
20 | Natural product-based amyloid inhibitors | Biochemical Pharmacology | 2017 | 155 |
21 | Higher-End Serotonin Receptors: 5-HT5, 5-HT6, and 5-HT7 | Journal of Medicinal Chemistry | 2003 | 154 |
22 | NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease | Molecular Neurobiology | 2018 | 153 |
23 | 2-Substituted Tryptamines: Agents with Selectivity for 5-HT6Serotonin Receptors | Journal of Medicinal Chemistry | 2000 | 149 |
24 | Structural Features Important for .sigma.1 Receptor Binding | Journal of Medicinal Chemistry | 1994 | 143 |
25 | The Electrotopological State: An Atom Index for QSAR | QSAR and Combinatorial Science | 1991 | 134 |
26 | Palladium-Catalyzed C–H Amination of C(sp2) and C(sp3)–H Bonds: Mechanism and Scope for N-Based Molecule Synthesis | ACS Catalysis | 2018 | 127 |
27 | A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury | Journal of Neuroinflammation | 2019 | 127 |
28 | 5-HT1 and 5-HT2 binding properties of derivatives of the hallucinugen 1-(2,5-dimethoxyphenyl)-2-aminopropane (2,5-DMA) | European Journal of Pharmacology | 1984 | 125 |
29 | New antithrombin-based anticoagulants | Medicinal Research Reviews | 2004 | 125 |
30 | Pharmacophore Identification for Sigma-1 (σ1) Receptor Binding: Application of the "Deconstruction - Reconstruction - Elaboration" Approach | Mini-Reviews in Medicinal Chemistry | 2005 | 125 |
31 | Vanillin, a potential agent for the treatment of sickle cell anemia | Blood | 1991 | 124 |
32 | Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectors | Journal of Medicinal Chemistry | 1991 | 123 |
33 | Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesis | Psychopharmacology | 1989 | 121 |
34 | Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 120 |
35 | Structure and activity of lipid bilayer within a membrane-protein transporter | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 119 |
36 | Agonist activity of LSD and lisuride at cloned 5HT 2A and 5HT 2C receptors | Psychopharmacology | 1998 | 117 |
37 | Abuse-related and abuse-limiting effects of methcathinone and the synthetic “bath salts” cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats | Psychopharmacology | 2014 | 115 |
38 | Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligands | Journal of Medicinal Chemistry | 1988 | 114 |
39 | Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelae | Journal of Bacteriology | 2001 | 111 |
40 | Hydrophobicity - Shake Flasks, Protein Folding and Drug Discovery | Current Topics in Medicinal Chemistry | 2010 | 111 |
41 | 3,4-Methylenedioxymethamphetamine (MDMA): Stereoselective interactions at brain 5-HT1 and 5-HT2 receptors | Psychopharmacology | 1986 | 109 |
42 | Huperzine A as Potential Treatment of Alzheimer's Disease: An Assessment on Chemistry, Pharmacology, and Clinical Studies | Chemistry and Biodiversity | 2011 | 108 |
43 | Hemoglobin: Structure, Function and Allostery | Sub-Cellular Biochemistry | 2020 | 106 |
44 | An index of electrotopological state for atoms in molecules | Journal of Mathematical Chemistry | 1991 | 105 |
45 | Crystal Structure of the Mycobacterium tuberculosisβ-Ketoacyl-Acyl Carrier Protein Synthase III | Journal of Biological Chemistry | 2001 | 103 |
46 | Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivity | Journal of Medicinal Chemistry | 1992 | 102 |
47 | Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration | Carcinogenesis | 2012 | 102 |
48 | Cathinone: An Investigation of Several N-Alkyl and Methylenedioxy-Substituted Analogs | Pharmacology Biochemistry and Behavior | 1997 | 101 |
49 | Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act synergistically at the human dopamine transporter | British Journal of Pharmacology | 2013 | 101 |
50 | Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancer | Oncotarget | 2016 | 100 |