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Top Articles

#TitleJournalYearCitations
1Predicting new molecular targets for known drugsNature20091,474
2Structure of the human κ-opioid receptor in complex with JDTicNature2012797
3A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of BehaviorNeuron2015320
4An electrotopological-state index for atoms in moleculesPharmaceutical Research1990319
5Amino acid side chain parameters for correlation studies in biology and pharmacologyInternational Journal of Peptide and Protein Research1988319
6Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogensPsychopharmacology1988308
7HINT: A new method of empirical hydrophobic field calculation for CoMFAJournal of Computer-Aided Molecular Design1991303
8A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the MouseJournal of Cardiovascular Pharmacology2014215
95-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cellsBritish Journal of Haematology2005211
10Improved Multilocus Sequence Typing Scheme for Staphylococcus epidermidisJournal of Clinical Microbiology2007207
11A Shape Index from Molecular GraphsQSAR and Combinatorial Science1985192
12Serotonin receptors: Clinical implicationsNeuroscience and Biobehavioral Reviews1990189
13Binding of β-carbolines and related agents at serotonin (5-HT2 and 5-HT1A), dopamine (D2) and benzodiazepine receptorsDrug and Alcohol Dependence2000182
14Vitamin B6 salvage enzymes: Mechanism, structure and regulationBiochimica Et Biophysica Acta - Proteins and Proteomics2011178
15NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)European Journal of Pharmacology1988174
16Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouseInternational Journal of Cardiology2016173
17Modeling Blood-Brain Barrier Partitioning Using the Electrotopological StateJournal of Chemical Information and Computer Sciences2002167
18Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxiaNature Communications2016163
19Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and InflammationInternational Journal of Molecular Sciences2019159
20Natural product-based amyloid inhibitorsBiochemical Pharmacology2017155
21Higher-End Serotonin Receptors:  5-HT5, 5-HT6, and 5-HT7Journal of Medicinal Chemistry2003154
22NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s DiseaseMolecular Neurobiology2018153
232-Substituted Tryptamines:  Agents with Selectivity for 5-HT6Serotonin ReceptorsJournal of Medicinal Chemistry2000149
24Structural Features Important for .sigma.1 Receptor BindingJournal of Medicinal Chemistry1994143
25The Electrotopological State: An Atom Index for QSARQSAR and Combinatorial Science1991134
26Palladium-Catalyzed C–H Amination of C(sp2) and C(sp3)–H Bonds: Mechanism and Scope for N-Based Molecule SynthesisACS Catalysis2018127
27A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injuryJournal of Neuroinflammation2019127
285-HT1 and 5-HT2 binding properties of derivatives of the hallucinugen 1-(2,5-dimethoxyphenyl)-2-aminopropane (2,5-DMA)European Journal of Pharmacology1984125
29New antithrombin-based anticoagulantsMedicinal Research Reviews2004125
30Pharmacophore Identification for Sigma-1 (σ1) Receptor Binding: Application of the "Deconstruction - Reconstruction - Elaboration" ApproachMini-Reviews in Medicinal Chemistry2005125
31Vanillin, a potential agent for the treatment of sickle cell anemiaBlood1991124
32Allosteric modifiers of hemoglobin. 2. Crystallographically determined binding sites and hydrophobic binding/interaction analysis of novel hemoglobin oxygen effectorsJournal of Medicinal Chemistry1991123
33Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesisPsychopharmacology1989121
34Ethyl-substituted erythromycin derivatives produced by directed metabolic engineeringProceedings of the National Academy of Sciences of the United States of America1998120
35Structure and activity of lipid bilayer within a membrane-protein transporterProceedings of the National Academy of Sciences of the United States of America2018119
36Agonist activity of LSD and lisuride at cloned 5HT 2A and 5HT 2C receptorsPsychopharmacology1998117
37Abuse-related and abuse-limiting effects of methcathinone and the synthetic “bath salts” cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in ratsPsychopharmacology2014115
38Arylpiperazine derivatives as high-affinity 5-HT1A serotonin ligandsJournal of Medicinal Chemistry1988114
39Characterization and Analysis of the PikD Regulatory Factor in the Pikromycin Biosynthetic Pathway of Streptomyces venezuelaeJournal of Bacteriology2001111
40Hydrophobicity - Shake Flasks, Protein Folding and Drug DiscoveryCurrent Topics in Medicinal Chemistry2010111
413,4-Methylenedioxymethamphetamine (MDMA): Stereoselective interactions at brain 5-HT1 and 5-HT2 receptorsPsychopharmacology1986109
42Huperzine A as Potential Treatment of Alzheimer's Disease: An Assessment on Chemistry, Pharmacology, and Clinical StudiesChemistry and Biodiversity2011108
43Hemoglobin: Structure, Function and AllosterySub-Cellular Biochemistry2020106
44An index of electrotopological state for atoms in moleculesJournal of Mathematical Chemistry1991105
45Crystal Structure of the Mycobacterium tuberculosisβ-Ketoacyl-Acyl Carrier Protein Synthase IIIJournal of Biological Chemistry2001103
46Binding of phenylalkylamine derivatives at 5-HT1C and 5-HT2 serotonin receptors: evidence for a lack of selectivityJournal of Medicinal Chemistry1992102
47Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migrationCarcinogenesis2012102
48Cathinone: An Investigation of Several N-Alkyl and Methylenedioxy-Substituted AnalogsPharmacology Biochemistry and Behavior1997101
49Bath salts components mephedrone and methylenedioxypyrovalerone (MDPV) act synergistically at the human dopamine transporterBritish Journal of Pharmacology2013101
50Carnitine palmitoyltransferase 1A functions to repress FoxO transcription factors to allow cell cycle progression in ovarian cancerOncotarget2016100