| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 2 | Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study | Clinical Infectious Diseases | 2004 | 3,871 |
| 3 | Diagnostic criteria and classification of mastocytosis: a consensus proposal | Leukemia Research | 2001 | 1,020 |
| 4 | Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values | Hepatology | 2003 | 984 |
| 5 | Function of Mitochondrial Stat3 in Cellular Respiration | Science | 2009 | 860 |
| 6 | Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial | Lancet, The | 2019 | 818 |
| 7 | Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome | New England Journal of Medicine | 1996 | 696 |
| 8 | Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19 | Nature Reviews Immunology | 2021 | 594 |
| 9 | A Randomized, Prospective, Double-Blind, Placebo-Controlled Trial of Terlipressin for Type 1 Hepatorenal Syndrome | Gastroenterology | 2008 | 588 |
| 10 | Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure | Gastroenterology | 2009 | 573 |
| 11 | Cardiac metastases | Journal of Clinical Pathology | 2007 | 520 |
| 12 | Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease | Gastroenterology | 2008 | 518 |
| 13 | Daily Assessment of Pain in Adults with Sickle Cell Disease | Annals of Internal Medicine | 2008 | 478 |
| 14 | An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases | Progress in Cardiovascular Diseases | 2018 | 460 |
| 15 | Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis | Journal of Translational Medicine | 2014 | 436 |
| 16 | Insulin Stimulates Testosterone Biosynthesis by Human Thecal Cells from Women with Polycystic Ovary Syndrome by Activating Its Own Receptor and Using Inositolglycan Mediators as the Signal Transduction System1 | Journal of Clinical Endocrinology and Metabolism | 1998 | 397 |
| 17 | Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia | Gastroenterology | 2016 | 387 |
| 18 | Diagnostic Value of Tryptase in Anaphylaxis and Mastocytosis | Immunology and Allergy Clinics of North America | 2006 | 376 |
| 19 | Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial | Lancet, The | 2018 | 374 |
| 20 | A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer | Journal of Hepatology | 2016 | 371 |
| 21 | Suppression of Serum Insulin by Diazoxide Reduces Serum Testosterone Levels in Obese Women with Polycystic Ovary Syndrome* | Journal of Clinical Endocrinology and Metabolism | 1989 | 335 |
| 22 | National Surveillance of Nosocomial Blood Stream Infection Due to Species of Candida Other than Candida albicans: Frequency of Occurrence and Antifungal Susceptibility in the SCOPE Program | Diagnostic Microbiology and Infectious Disease | 1998 | 331 |
| 23 | Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone | Fertility and Sterility | 2001 | 319 |
| 24 | Lean Women with Polycystic Ovary Syndrome Respond to Insulin Reduction with Decreases in Ovarian P450c17α Activity and Serum Androgens1 | Journal of Clinical Endocrinology and Metabolism | 1997 | 315 |
| 25 | Portal Hypertension and Its Complications | Gastroenterology | 2008 | 303 |
| 26 | POSITION STATEMENT: Glucose Intolerance in Polycystic Ovary Syndrome—A Position Statement of the Androgen Excess Society | Journal of Clinical Endocrinology and Metabolism | 2007 | 301 |
| 27 | Pathogenic Roles for Fungal Melanins | Clinical Microbiology Reviews | 2000 | 291 |
| 28 | Cirrhotic Cardiomyopathy | Journal of the American College of Cardiology | 2010 | 288 |
| 29 | Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number | Nature Genetics | 2016 | 279 |
| 30 | The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids | Hepatology | 2018 | 266 |
| 31 | Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 263 |
| 32 | AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data | Bone Marrow Transplantation | 2008 | 261 |
| 33 | Citalopram, QTc Interval Prolongation, and Torsade de Pointes. How Should We Apply the Recent FDA Ruling? | American Journal of Medicine | 2012 | 260 |
| 34 | Metformin for the Treatment of the Polycystic Ovary Syndrome | New England Journal of Medicine | 2008 | 258 |
| 35 | Screening for Lung Cancer With Low-Dose Computed Tomography | JAMA - Journal of the American Medical Association | 2021 | 258 |
| 36 | Development of a new, more sensitive immunoassay for human tryptase: Use in systemic anaphylaxis | Journal of Clinical Immunology | 1994 | 257 |
| 37 | The Role of Chemotherapy at the End of Life | JAMA - Journal of the American Medical Association | 2008 | 241 |
| 38 | Nosocomial bloodstream infections due to Candida spp. in the USA: species distribution, clinical features and antifungal susceptibilities | International Journal of Antimicrobial Agents | 2014 | 238 |
| 39 | Do cancer centers designated by the National Cancer Institute have better surgical outcomes? | Cancer | 2005 | 236 |
| 40 | Signal Detectability | Medical Decision Making | 1991 | 233 |
| 41 | Sildenafil Induces Delayed Preconditioning Through Inducible Nitric Oxide Synthase–Dependent Pathway in Mouse Heart | Circulation Research | 2003 | 225 |
| 42 | Antimicrobial Susceptibility and Selection of Resistance Among Staphylococcus epidermidis Isolates Recovered from Patients with Infections of Indwelling Foreign Devices | Antimicrobial Agents and Chemotherapy | 1978 | 224 |
| 43 | The Antibiotic Pipeline — Challenges, Costs, and Values | New England Journal of Medicine | 2004 | 224 |
| 44 | An Shp2/SFK/Ras/Erk Signaling Pathway Controls Trophoblast Stem Cell Survival | Developmental Cell | 2006 | 222 |
| 45 | Predictors of response to terlipressin plus albumin in hepatorenal syndrome (HRS) type 1: Relationship of serum creatinine to hemodynamics | Journal of Hepatology | 2011 | 216 |
| 46 | Laboratory Investigation of Deaths Due to Anaphylaxis | Journal of Forensic Sciences | 1991 | 216 |
| 47 | Evidence for the Effectiveness of Techniques To Change Physician Behavior | Chest | 2000 | 213 |
| 48 | Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome | Fertility and Sterility | 2002 | 208 |
| 49 | 17‐Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease | Hepatology | 2019 | 200 |
| 50 | COVID-19 and telehealth, education, and research adaptations | Paediatric Respiratory Reviews | 2020 | 198 |
