| # | Title | Journal | Year | Citations |
|---|
| 1 | Role for CD47-SIRP signaling in xenograft rejection by macrophages | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 270 |
| 2 | Prognostic Factors After Surgical Resection for Intrahepatic, Hilar, and Distal Cholangiocarcinoma | Annals of Surgical Oncology | 2011 | 210 |
| 3 | Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling | Biochemical Journal | 2007 | 198 |
| 4 | Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection | Proceedings of the National Academy of Sciences of the United States of America | 2013 | 170 |
| 5 | Difference in cytotoxicity against hepatocellular carcinoma between liver and periphery natural killer cells in humans | Hepatology | 2006 | 158 |
| 6 | Prognostic Impact of Perioperative Serum CA 19-9 Levels in Patients with Resectable Pancreatic Cancer | Annals of Surgical Oncology | 2010 | 146 |
| 7 | Impact of Rituximab Desensitization on Blood-Type-Incompatible Adult Living Donor Liver Transplantation: A Japanese Multicenter Study | American Journal of Transplantation | 2014 | 141 |
| 8 | Number of Metastatic Lymph Nodes, but Not Lymph Node Ratio, Is an Independent Prognostic Factor after Resection of Pancreatic Carcinoma | Journal of the American College of Surgeons | 2010 | 140 |
| 9 | Repeat hepatectomy for recurrent hepatocellular carcinoma | Surgery | 2007 | 136 |
| 10 | Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers | Oncogene | 2003 | 135 |
| 11 | Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation | Journal of the American College of Cardiology | 2004 | 133 |
| 12 | Prognostic value of circulating tumour DNA in patients undergoing curative resection for pancreatic cancer | British Journal of Cancer | 2016 | 133 |
| 13 | Identification of 20 genes aberrantly methylated in human breast cancers | International Journal of Cancer | 2005 | 129 |
| 14 | Liver NK cells expressing TRAIL are toxic against self hepatocytes in mice | Hepatology | 2004 | 126 |
| 15 | Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer | Cancer | 1991 | 119 |
| 16 | EGF and TGF-α, the ligands of hyperproduced EGFR in human esophageal carcinoma cells, act as autocrine growth factors | International Journal of Cancer | 1990 | 115 |
| 17 | The long-term survival of stage IV gastric cancer patients with conversion therapy | Gastric Cancer | 2018 | 111 |
| 18 | Chemoprevention ofN-Nitroso-N-methylurea-induced Rat Mammary Carcinogenesis by Soy Foods or Biochanin A | Japanese Journal of Cancer Research | 1998 | 110 |
| 19 | Proposed Nomogram Predicting the Individual Risk of Malignancy in the Patients With Branch Duct Type Intraductal Papillary Mucinous Neoplasms of the Pancreas | Annals of Surgery | 2017 | 110 |
| 20 | Portal or superior mesenteric vein resection in pancreatoduodenectomy for pancreatic head carcinoma | British Journal of Surgery | 2015 | 109 |
| 21 | Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice | International Journal of Cancer | 1992 | 108 |
| 22 | Genetic analysis of polymorphisms in biologically relevant candidate genes in patients with abdominal aortic aneurysms | Journal of Vascular Surgery | 2005 | 108 |
| 23 | Adjuvant Gemcitabine Plus S-1 Chemotherapy Improves Survival After Aggressive Surgical Resection for Advanced Biliary Carcinoma | Annals of Surgery | 2009 | 107 |
| 24 | Expression of Epidermal Growth Factor, Transforming Growth Factor-α and Their Receptor Genes in Human Gastric Carcinomas; Implication for Autocrine Growth | Japanese Journal of Cancer Research | 1990 | 104 |
| 25 | Prognostic significance of lymph node metastasis and surgical margin status for distal cholangiocarcinoma | Journal of Surgical Oncology | 2007 | 104 |
| 26 | Expression of TGF-β and procollagen type I and type III in human gastric carcinomas | International Journal of Cancer | 1989 | 97 |
| 27 | Proposed preoperative risk factors for early recurrence in patients with resectable pancreatic ductal adenocarcinoma after surgical resection: A multi-center retrospective study | Pancreatology | 2015 | 95 |
| 28 | Relationship between epidermal growth factor receptor status and various prognostic factors in human breast cancer | Cancer | 1990 | 92 |
| 29 | Pancreatoduodenectomy for Distal Cholangiocarcinoma: Prognostic Impact of Lymph Node Metastasis | World Journal of Surgery | 2007 | 89 |
| 30 | Gemcitabine-Based Adjuvant Chemotherapy Improves Survival After Aggressive Surgery for Hilar Cholangiocarcinoma | Journal of Gastrointestinal Surgery | 2009 | 88 |
| 31 | Amplification of epidermal growth factor receptor (EGFR) gene and oncogenes in human gastric carcinomas | Vigiliae Christianae | 1989 | 86 |
| 32 | Chemotherapy combined with or without hyperthermia for patients with oesophageal carcinoma: a prospective randomized trial | International Journal of Hyperthermia | 1994 | 86 |
| 33 | Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery | Annals of Surgical Oncology | 2019 | 85 |
| 34 | α1,3-Galactosyltransferase Gene-Knockout Pigs for Xenotransplantation: Where Do We Go From Here? | Transplantation | 2007 | 83 |
| 35 | Specific Antibiotic Prophylaxis Based on Bile Cultures Is Required to Prevent Postoperative Infectious Complications in Pancreatoduodenectomy Patients Who Have Undergone Preoperative Biliary Drainage | World Journal of Surgery | 2007 | 83 |
| 36 | Clinicopathologic features of poorly differentiated hepatocellular carcinoma | Journal of Surgical Oncology | 2007 | 82 |
| 37 | Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus | Metabolism: Clinical and Experimental | 2008 | 79 |
| 38 | Expression of integrin-linked kinase is closely correlated with invasion and metastasis of gastric carcinoma | Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin | 2003 | 73 |
| 39 | Sarpogrelate Hydrochloride, a Selective 5-HT2A Antagonist, Improves Vascular Function in Patients With Peripheral Arterial Disease | Journal of Cardiovascular Pharmacology | 2007 | 73 |
| 40 | Sarcopenia is closely associated with pancreatic exocrine insufficiency in patients with pancreatic disease | Pancreatology | 2017 | 72 |
| 41 | Predictive Factors for Exocrine Pancreatic Insufficiency After Pancreatoduodenectomy with Pancreaticogastrostomy | Journal of Gastrointestinal Surgery | 2009 | 70 |
| 42 | Prognostic significance of co-expression of c-erbB-2 oncoprotein and epidermal growth factor receptor in breast cancer patients | American Journal of Surgery | 1992 | 68 |
| 43 | Combined Assessment of β-d-Glucan and Degree of Candida Colonization before Starting Empiric Therapy for Candidiasis in Surgical Patients | World Journal of Surgery | 2004 | 68 |
| 44 | Liver Sinusoidal Endothelial Cells Tolerize T Cells across MHC Barriers in Mice | Journal of Immunology | 2005 | 68 |
| 45 | Hepatectomy for Hepatocellular Carcinoma in Elderly Patients Aged 75 Years or More | Journal of Gastrointestinal Surgery | 2009 | 68 |
| 46 | Induction of Growth Factor-receptor and Metalloproteinase Genes by Epidermal Growth Factor and/or Transforming Growth Factor-α in Human Gastric Carcinoma Cell Line MKN-28 | Japanese Journal of Cancer Research | 1990 | 64 |
| 47 | Expression of cripto, a Novel Gene of the Epidermal Growth Factor Family, in Human Gastrointestinal Carcinomas | Japanese Journal of Cancer Research | 1991 | 64 |
| 48 | Prognostic Impact of Para‐aortic Lymph Node Metastasis in Pancreatic Ductal Adenocarcinoma | World Journal of Surgery | 2010 | 63 |
| 49 | Postoperative prognosis of pancreatic cancer with para-aortic lymph node metastasis: a multicenter study on 822 patients | Journal of Gastroenterology | 2015 | 63 |
| 50 | Immunocytochemical and biochemical analysis of epidermal growth factor receptor expression in human breast cancer tissues: Relationship to estrogen receptor and lymphatic invasion | International Journal of Cancer | 1989 | 62 |
