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Top Articles

#TitleJournalYearCitations
1RASP (Reconstruct Ancestral State in Phylogenies): A tool for historical biogeographyMolecular Phylogenetics and Evolution20151,049
2Chemistry, Biology, and Medicine of Fluorescent Nanomaterials and Related Systems: New Insights into Biosensing, Bioimaging, Genomics, Diagnostics, and TherapyChemical Reviews2014693
3S-DIVA (Statistical Dispersal-Vicariance Analysis): A tool for inferring biogeographic historiesMolecular Phylogenetics and Evolution2010667
4FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associationsDatabase: the Journal of Biological Databases and Curation2020469
5An improved sensitivity non-enzymatic glucose sensor based on a CuO nanowire modified Cu electrodeAnalyst, The2008449
6Targeting STAT3 in Cancer ImmunotherapyMolecular Cancer2020423
7CB-Dock: a web server for cavity detection-guided protein–ligand blind dockingActa Pharmacologica Sinica2020377
8Regulation of Plant Responses to Salt StressInternational Journal of Molecular Sciences2021361
9RASP 4: Ancestral State Reconstruction Tool for Multiple Genes and CharactersMolecular Biology and Evolution2020338
10Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesisNature2019330
11Expression of an Arabidopsis vacuolar H+‐pyrophosphatase gene (AVP1) in cotton improves drought‐ and salt tolerance and increases fibre yield in the field conditionsPlant Biotechnology Journal2011253
12Using the augmented Chou's pseudo amino acid composition for predicting protein submitochondria locations based on auto covariance approachJournal of Theoretical Biology2009242
13Structural basis for outer membrane lipopolysaccharide insertionNature2014239
14Structural basis of outer membrane protein insertion by the BAM complexNature2016234
15Purification, composition analysis and antioxidant activity of the polysaccharides from Dendrobium nobile Lindl.Carbohydrate Polymers2010228
16Structures and biological functions of IL-31 and IL-31 receptorsCytokine and Growth Factor Reviews2008226
17Purification and characterization of a fibrinolytic enzyme produced by Bacillus amyloliquefaciens DC-4 screened from douchi, a traditional Chinese soybean foodComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology2003221
18CB-Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fittingNucleic Acids Research2022219
19Exosomal tRNA-derived small RNA as a promising biomarker for cancer diagnosisMolecular Cancer2019204
20Genomic Flatlining in the Endangered Island FoxCurrent Biology2016201
21Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivoApplied Microbiology and Biotechnology2005199
22Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS–p38–p53 pathwayCancer Letters2009195
23Characterization of antioxidant polysaccharides from Auricularia auricular using microwave-assisted extractionCarbohydrate Polymers2012185
24Effect of modified coconut shell biochar on availability of heavy metals and biochemical characteristics of soil in multiple heavy metals contaminated soilScience of the Total Environment2018182
25Evolutionary history and underlying adaptation of alpine plants on the Qinghai–Tibet PlateauJournal of Systematics and Evolution2014180
26Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancerCell Death and Disease2014177
27Highly Efficient A·T to G·C Base Editing by Cas9n-Guided tRNA Adenosine Deaminase in RiceMolecular Plant2018177
28Regulated Expression of an Isopentenyltransferase Gene (IPT) in Peanut Significantly Improves Drought Tolerance and Increases Yield Under Field ConditionsPlant and Cell Physiology2011174
29Comprehensive Profiling of Ethylene Response Factor Expression Identifies Ripening-Associated ERF Genes and Their Link to Key Regulators of Fruit Ripening in TomatoPlant Physiology2016171
30Hypoxia Adaptations in the Grey Wolf (Canis lupus chanco) from Qinghai-Tibet PlateauPLoS Genetics2014169
31Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9-Guided Hyperactive hAID MutantMolecular Plant2018169
32The molecular mechanisms of copper metabolism and its roles in human diseasesPflugers Archiv European Journal of Physiology2020167
33Long noncoding RNA OCC-1 suppresses cell growth through destabilizing HuR protein in colorectal cancerNucleic Acids Research2018165
34Inhibition of Stat3 Activation Suppresses Caspase-3 and the Ubiquitin-Proteasome System, Leading to Preservation of Muscle Mass in Cancer CachexiaJournal of Biological Chemistry2015164
35Worldwide patterns of genomic variation and admixture in gray wolvesGenome Research2016160
36Deconvoluting the role of reactive oxygen species and autophagy in human diseasesFree Radical Biology and Medicine2013156
37Genome-wide Evidence Reveals that African and Eurasian Golden Jackals Are Distinct SpeciesCurrent Biology2015156
38Digital Gene Expression Analysis Based on Integrated De Novo Transcriptome Assembly of Sweet Potato [Ipomoea batatas (L.) Lam.]PLoS ONE2012156
39Itraconazole suppresses the growth of glioblastoma through induction of autophagyAutophagy2014155
40Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissuesInternational Journal of Obesity2016155
41Impacts of plastic film mulching on crop yields, soil water, nitrate, and organic carbon in Northwestern China: A meta-analysisAgricultural Water Management2018153
42Composition analysis and antioxidant activity of polysaccharide from Dendrobium denneanumInternational Journal of Biological Macromolecules2009152
43LncRNA GABPB1-AS1 and GABPB1 regulate oxidative stress during erastin-induced ferroptosis in HepG2 hepatocellular carcinoma cellsScientific Reports2019151
44Whole-genome sequence analysis shows that two endemic species of North American wolf are admixtures of the coyote and gray wolfScience Advances2016150
45Tumor microenvironment: The culprit for ovarian cancer metastasis?Cancer Letters2016149
46Superior Performance of Aptamer in Tumor Penetration over Antibody: Implication of Aptamer-Based Theranostics in Solid TumorsTheranostics2015147
47Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin productionApplied Microbiology and Biotechnology2013142
48Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal ModelsFrontiers in Physiology2016142
49Plastome phylogeny and early diversification of BrassicaceaeBMC Genomics2017137
50Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53Nature Communications2015134