| # | Title | Journal | Year | Citations |
|---|
| 1 | Insulin Resistance: A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease | Diabetes Care | 1991 | 3,723 |
| 2 | Increased bone formation in osteocalcin-deficient mice | Nature | 1996 | 1,522 |
| 3 | Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors | Nature | 1986 | 1,390 |
| 4 | Type 2 diabetes mellitus | Nature Reviews Disease Primers | 2015 | 1,308 |
| 5 | Prospective Analysis of The Insulin-Resistance Syndrome (Syndrome X) | Diabetes | 1992 | 1,102 |
| 6 | A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism | Journal of Biological Chemistry | 2000 | 1,093 |
| 7 | The Influence of CCL3L1 Gene-Containing Segmental Duplications on HIV-1/AIDS Susceptibility | Science | 2005 | 1,040 |
| 8 | The genetic architecture of type 2 diabetes | Nature | 2016 | 952 |
| 9 | Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes? | JAMA - Journal of the American Medical Association | 1990 | 875 |
| 10 | Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome | Diabetologia | 1991 | 859 |
| 11 | Estrogen promotes apoptosis of murine osteoclasts mediated by TGF–β | Nature Medicine | 1996 | 740 |
| 12 | The Homeostasis Model in the San Antonio Heart Study | Diabetes Care | 1997 | 722 |
| 13 | Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu | Breast Cancer Research and Treatment | 1992 | 670 |
| 14 | Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis | Diabetes | 1995 | 652 |
| 15 | The value of estrogen and progesterone receptors in the treatment of breast cancer | Cancer | 1980 | 629 |
| 16 | Bone mineral loss and recovery after 17 weeks of bed rest | Journal of Bone and Mineral Research | 1990 | 628 |
| 17 | Stroke with intermittent atrial fibrillation: incidence and predictors during aspirin therapy | Journal of the American College of Cardiology | 2000 | 611 |
| 18 | Does the Metabolic Syndrome Improve Identification of Individuals at Risk of Type 2 Diabetes and/or Cardiovascular Disease? | Diabetes Care | 2004 | 608 |
| 19 | Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome | Arthritis and Rheumatism | 1994 | 590 |
| 20 | Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities | Nature | 2012 | 560 |
| 21 | Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry | New England Journal of Medicine | 1989 | 542 |
| 22 | Biological effects of conjugated linoleic acids in health and disease | Journal of Nutritional Biochemistry | 2006 | 538 |
| 23 | Predicting response to endocrine therapy in human breast cancer: a hypothesis | Science | 1975 | 536 |
| 24 | HER-2/neu oncogene protein and prognosis in breast cancer. | Journal of Clinical Oncology | 1989 | 536 |
| 25 | Cell biology of the osteoclast | Experimental Hematology | 1999 | 511 |
| 26 | Coronary flow reserve as a physiologic measure of stenosis severity | Journal of the American College of Cardiology | 1990 | 494 |
| 27 | Effect of Lowering LDL Cholesterol Substantially Below Currently Recommended Levels in Patients With Coronary Heart Disease and Diabetes: The Treating to New Targets (TNT) study | Diabetes Care | 2006 | 493 |
| 28 | Interventions to Slow Aging in Humans: Are We Ready? | Aging Cell | 2015 | 481 |
| 29 | Differences in A1C by Race and Ethnicity Among Patients With Impaired Glucose Tolerance in the Diabetes Prevention Program | Diabetes Care | 2007 | 479 |
| 30 | β-Cell Function in Subjects Spanning the Range from Normal Glucose Tolerance to Overt Diabetes: A New Analysis | Journal of Clinical Endocrinology and Metabolism | 2005 | 470 |
| 31 | Cathepsin D and Prognosis in Breast Cancer | New England Journal of Medicine | 1990 | 459 |
| 32 | The Metabolic Syndrome: Inflammation, Diabetes Mellitus, and Cardiovascular Disease | American Journal of Cardiology | 2006 | 457 |
| 33 | Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures | Hepatology | 2014 | 456 |
| 34 | Nox4 NAD(P)H Oxidase Mediates Hypertrophy and Fibronectin Expression in the Diabetic Kidney | Journal of Biological Chemistry | 2005 | 451 |
| 35 | Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis | Arthritis and Rheumatism | 1992 | 446 |
| 36 | Scatchard plots: Common errors in correction and interpretation | Steroids | 1975 | 444 |
| 37 | A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2 | Nature Genetics | 1997 | 431 |
| 38 | Incidence of Type II Diabetes in Mexican Americans Predicted by Fasting Insulin and Glucose Levels, Obesity, and Body-Fat Distribution | Diabetes | 1990 | 417 |
| 39 | Subcellular localization of Nox4 and regulation in diabetes | Proceedings of the National Academy of Sciences of the United States of America | 2009 | 416 |
| 40 | The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia | Diabetes, Obesity and Metabolism | 2012 | 398 |
| 41 | Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes | Diabetes, Obesity and Metabolism | 2015 | 392 |
| 42 | MCF-7: A human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors | Steroids | 1975 | 374 |
| 43 | Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases | Diabetes/Metabolism Research and Reviews | 2006 | 373 |
| 44 | Advances in Bone Biology: The Osteoclast* | Endocrine Reviews | 1996 | 372 |
| 45 | Mechanism of Metformin Action in Obese and Lean Noninsulin-Dependent Diabetic Subjects* | Journal of Clinical Endocrinology and Metabolism | 1991 | 363 |
| 46 | Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts | Journal of Biological Chemistry | 2002 | 361 |
| 47 | CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression | Cancer Research | 2010 | 361 |
| 48 | Epidemic Obesity and the Metabolic Syndrome | Circulation | 2003 | 357 |
| 49 | Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases | Kidney International | 2011 | 353 |
| 50 | Effects of Interleukin-1 on Bone Turnover in Normal Mice* | Endocrinology | 1989 | 352 |
