| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 2 | Inflammation and its role in age-related macular degeneration | Cellular and Molecular Life Sciences | 2016 | 489 |
| 3 | The expanding role of prodrugs in contemporary drug design and development | Nature Reviews Drug Discovery | 2018 | 478 |
| 4 | Pharmacokinetic aspects of retinal drug delivery | Progress in Retinal and Eye Research | 2017 | 454 |
| 5 | Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset | Blood | 2012 | 443 |
| 6 | Prodrugs—from Serendipity to Rational Design | Pharmacological Reviews | 2011 | 410 |
| 7 | Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma | Journal of Clinical Investigation | 2018 | 406 |
| 8 | Personal protective equipment for preventing highly infectious diseases due to exposure to contaminated body fluids in healthcare staff | The Cochrane Library | 2020 | 313 |
| 9 | Binding Affinity via Docking: Fact and Fiction | Molecules | 2018 | 292 |
| 10 | Human breast cancer cells educate macrophages toward the M2 activation status | Breast Cancer Research | 2015 | 291 |
| 11 | Sirtuin functions and modulation: from chemistry to the clinic | Clinical Epigenetics | 2016 | 291 |
| 12 | Amino acids as co-amorphous stabilizers for poorly water soluble drugs – Part 1: Preparation, stability and dissolution enhancement | European Journal of Pharmaceutics and Biopharmaceutics | 2013 | 246 |
| 13 | Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration | Progress in Retinal and Eye Research | 2020 | 239 |
| 14 | An overview of recent studies on the analysis of pharmaceutical polymorphs | Journal of Pharmaceutical and Biomedical Analysis | 2011 | 233 |
| 15 | 20‐year follow‐up study of physical morbidity and mortality in relationship to antipsychotic treatment in a nationwide cohort of 62,250 patients with schizophrenia (FIN20) | World Psychiatry | 2020 | 232 |
| 16 | Indolepropionic acid and novel lipid metabolites are associated with a lower risk of type 2 diabetes in the Finnish Diabetes Prevention Study | Scientific Reports | 2017 | 228 |
| 17 | A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer | Nature Medicine | 2016 | 207 |
| 18 | Prodrugs in medicinal chemistry and enzyme prodrug therapies | Advanced Drug Delivery Reviews | 2017 | 202 |
| 19 | Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions | European Journal of Pharmaceutics and Biopharmaceutics | 2012 | 197 |
| 20 | Future directions in Alzheimer's disease from risk factors to prevention | Biochemical Pharmacology | 2014 | 181 |
| 21 | The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection | Cell Systems | 2015 | 179 |
| 22 | Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease | International Journal of Geriatric Psychiatry | 2011 | 175 |
| 23 | Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via Oxidative Stress in Diet-Induced Obese C57Bl/6 Mice | Circulation Journal | 2010 | 165 |
| 24 | Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development | Processes | 2021 | 162 |
| 25 | Mortality in people with schizophrenia: a systematic review and meta‐analysis of relative risk and aggravating or attenuating factors | World Psychiatry | 2022 | 156 |
| 26 | Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease | Journal of Neurochemistry | 2017 | 154 |
| 27 | Associations of serum indolepropionic acid, a gut microbiota metabolite, with type 2 diabetes and low-grade inflammation in high-risk individuals | Nutrition and Diabetes | 2018 | 147 |
| 28 | Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways | Ageing Research Reviews | 2016 | 144 |
| 29 | Plasma levels of the proprotein convertase furin and incidence of diabetes and mortality | Journal of Internal Medicine | 2018 | 144 |
| 30 | Bone metastasis targeting: A novel approach to reach bone using Zoledronate anchored PLGA nanoparticle as carrier system loaded with Docetaxel | Journal of Controlled Release | 2012 | 140 |
| 31 | Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ | Biochemical Pharmacology | 2014 | 140 |
| 32 | Pioglitazone and bladder cancer risk: a multipopulation pooled, cumulative exposure analysis | Diabetologia | 2015 | 140 |
| 33 | From prescription drug purchases to drug use periods – a second generation method (PRE2DUP) | BMC Medical Informatics and Decision Making | 2015 | 137 |
| 34 | Nontargeted Metabolite Profiling Discriminates Diet-Specific Biomarkers for Consumption of Whole Grains, Fatty Fish, and Bilberries in a Randomized Controlled Trial | Journal of Nutrition | 2015 | 129 |
| 35 | Immobilization of protein-coated drug nanoparticles in nanofibrillar cellulose matrices—Enhanced stability and release | Journal of Controlled Release | 2011 | 128 |
| 36 | Design principles of ocular drug delivery systems: importance of drug payload, release rate, and material properties | Drug Discovery Today | 2019 | 124 |
| 37 | Refining stability and dissolution rate of amorphous drug formulations | Expert Opinion on Drug Delivery | 2014 | 119 |
| 38 | Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration | Redox Biology | 2019 | 117 |
| 39 | NLRP3 inflammasome activation is associated with proliferative diabetic retinopathy | Acta Ophthalmologica | 2017 | 112 |
| 40 | DeepCDA: deep cross-domain compound–protein affinity prediction through LSTM and convolutional neural networks | Bioinformatics | 2020 | 110 |
| 41 | Dementia and oral health among subjects aged 75 years or older | Gerodontology | 2012 | 109 |
| 42 | Natural polyphenols as sirtuin 6 modulators | Scientific Reports | 2018 | 109 |
| 43 | Intravitreal clearance and volume of distribution of compounds in rabbits: In silico prediction and pharmacokinetic simulations for drug development | European Journal of Pharmaceutics and Biopharmaceutics | 2015 | 108 |
| 44 | Integrated analysis of isopentenyl pyrophosphate (IPP) toxicity in isoprenoid-producing Escherichia coli | Metabolic Engineering | 2018 | 106 |
| 45 | Metabolic alterations in Parkinson’s disease astrocytes | Scientific Reports | 2020 | 104 |
| 46 | Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine | Pharmaceutical Research | 2013 | 102 |
| 47 | Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells | Journal of Medicinal Chemistry | 2014 | 102 |
| 48 | Immunosenescence: the potential role of myeloid-derived suppressor cells (MDSC) in age-related immune deficiency | Cellular and Molecular Life Sciences | 2019 | 102 |
| 49 | Integrative and Personalized QSAR Analysis in Cancer by Kernelized Bayesian Matrix Factorization | Journal of Chemical Information and Modeling | 2014 | 101 |
| 50 | Brinzolamide nanocrystal formulations for ophthalmic delivery: Reduction of elevated intraocular pressure in vivo | International Journal of Pharmaceutics | 2014 | 99 |
