| # | Title | Journal | Year | Citations |
|---|
| 1 | Biochemistry and molecular cell biology of diabetic complications | Nature | 2001 | 7,641 |
| 2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 3 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 4 | Autophagy regulates lipid metabolism | Nature | 2009 | 3,149 |
| 5 | Stat3 as an Oncogene | Cell | 1999 | 2,610 |
| 6 | Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders | Pharmacogenetics and Genomics | 1996 | 1,681 |
| 7 | Subclinical Thyroid Disease | JAMA - Journal of the American Medical Association | 2004 | 1,532 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 9 | The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 | Cell | 1998 | 1,412 |
| 10 | The Biological Basis for Cardiac Repair After Myocardial Infarction | Circulation Research | 2016 | 1,408 |
| 11 | The Role of Cockroach Allergy and Exposure to Cockroach Allergen in Causing Morbidity among Inner-City Children with Asthma | New England Journal of Medicine | 1997 | 1,259 |
| 12 | 25-Hydroxyvitamin D Levels and the Risk of Mortality in the General Population | Archives of Internal Medicine | 2008 | 1,073 |
| 13 | Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions | Cell | 2010 | 1,069 |
| 14 | Nanotechnology as a therapeutic tool to combat microbial resistance | Advanced Drug Delivery Reviews | 2013 | 1,048 |
| 15 | Complex Distribution, Not Absolute Amount of Adiponectin, Correlates with Thiazolidinedione-mediated Improvement in Insulin Sensitivity | Journal of Biological Chemistry | 2004 | 1,018 |
| 16 | Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 996 |
| 17 | The Role of Sialic Acid in Determining the Survival of Glycoproteins in the Circulation | Journal of Biological Chemistry | 1971 | 977 |
| 18 | Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury | Critical Care | 2013 | 969 |
| 19 | Regulation of the Inflammatory Response in Cardiac Repair | Circulation Research | 2012 | 940 |
| 20 | Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis | Case Reports in Gastroenterology | 2015 | 902 |
| 21 | The polypeptides of adenovirus | Virology | 1968 | 862 |
| 22 | Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI | Molecular and Cellular Biology | 2009 | 862 |
| 23 | Hypothalamic insulin signaling is required for inhibition of glucose production | Nature Medicine | 2002 | 785 |
| 24 | The convalescent sera option for containing COVID-19 | Journal of Clinical Investigation | 2020 | 775 |
| 25 | Sickle-cell disease | Lancet, The | 2004 | 755 |
| 26 | Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption | Cell | 2006 | 748 |
| 27 | Molecular, biochemical, and cellular pharmacology of pemetrexed | Seminars in Oncology | 2002 | 743 |
| 28 | A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus | Nature Medicine | 2001 | 721 |
| 29 | Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US | JAMA Internal Medicine | 2020 | 711 |
| 30 | Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition | EMBO Journal | 2004 | 682 |
| 31 | Autophagy in the Cellular Energetic Balance | Cell Metabolism | 2011 | 673 |
| 32 | Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes | Biochemical and Biophysical Research Communications | 1990 | 662 |
| 33 | The Critical Role of Metabolic Pathways in Aging | Diabetes | 2012 | 647 |
| 34 | Toxoplasmosis: A history of clinical observations | International Journal for Parasitology | 2009 | 644 |
| 35 | Host-Pathogen Interactions: Redefining the Basic Concepts of Virulence and Pathogenicity | Infection and Immunity | 1999 | 597 |
| 36 | Age-Specific Distribution of Serum Thyrotropin and Antithyroid Antibodies in the U.S. Population: Implications for the Prevalence of Subclinical Hypothyroidism | Journal of Clinical Endocrinology and Metabolism | 2007 | 590 |
| 37 | Autophagy regulates adipose mass and differentiation in mice | Journal of Clinical Investigation | 2009 | 580 |
| 38 | Hypothalamic KATP channels control hepatic glucose production | Nature | 2005 | 569 |
| 39 | Effect of Gender on the Progression of Nondiabetic Renal Disease | Journal of the American Society of Nephrology: JASN | 2000 | 563 |
| 40 | Ligandin: a Hepatic Protein which Binds Steroids, Bilirubin, Carcinogens and a Number of Exogenous Organic Anions | Nature | 1971 | 560 |
| 41 | Epidemiology of Lung Cancer | Chest | 2013 | 559 |
| 42 | Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists | Journal of Biological Chemistry | 2006 | 558 |
| 43 | A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth | PLoS ONE | 2009 | 553 |
| 44 | Transmission of the Human Immunodeficiency Virus | New England Journal of Medicine | 1987 | 540 |
| 45 | The contribution of melanin to microbial pathogenesis | Cellular Microbiology | 2003 | 538 |
| 46 | Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis | Microbiology (United Kingdom) | 2002 | 534 |
| 47 | Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A | Journal of Biological Chemistry | 2001 | 530 |
| 48 | Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues | Gastroenterology | 2012 | 523 |
| 49 | Connecting copper and cancer: from transition metal signalling to metalloplasia | Nature Reviews Cancer | 2022 | 519 |
| 50 | Somatic Inactivation of Pkd2 Results in Polycystic Kidney Disease | Cell | 1998 | 511 |
