| # | Title | Journal | Year | Citations |
|---|
| 1 | European Position Paper on Rhinosinusitis and Nasal Polyps 2020 | Rhinology | 2020 | 1,555 |
| 2 | FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data | Cytometry Part A: the Journal of the International Society for Analytical Cytology | 2015 | 1,337 |
| 3 | Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials | Lancet Respiratory Medicine,the | 2015 | 937 |
| 4 | Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial | Lancet, The | 2019 | 804 |
| 5 | Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma | Journal of Allergy and Clinical Immunology | 2013 | 592 |
| 6 | Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks | Nature Genetics | 2018 | 426 |
| 7 | Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial | Thorax | 2013 | 421 |
| 8 | Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function | Nature Genetics | 2011 | 367 |
| 9 | Tiotropium and olodaterol fixed-dose combinationversusmono-components in COPD (GOLD 2–4) | European Respiratory Journal | 2015 | 294 |
| 10 | Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence | Journal of Allergy and Clinical Immunology | 2020 | 272 |
| 11 | Eosinophils in the Spotlight: Eosinophilic airway inflammation in nonallergic asthma | Nature Medicine | 2013 | 264 |
| 12 | EUFOREA consensus on biologics for CRSwNP with or without asthma | Allergy: European Journal of Allergy and Clinical Immunology | 2019 | 239 |
| 13 | Role of IL-1 and the Nlrp3/caspase-1/IL-1 axis in cigarette smoke-induced pulmonary inflammation and COPD | European Respiratory Journal | 2011 | 221 |
| 14 | Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR) | Respiratory Medicine | 2014 | 215 |
| 15 | MicroRNA Expression in Induced Sputum of Smokers and Patients with Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2011 | 209 |
| 16 | Prevalence and incidence of COPD in smokers and non-smokers: the Rotterdam Study | European Journal of Epidemiology | 2016 | 199 |
| 17 | Global Initiative for Asthma Strategy 2021: Executive Summary and Rationale for Key Changes | American Journal of Respiratory and Critical Care Medicine | 2022 | 196 |
| 18 | Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | 2007 | 194 |
| 19 | Asthma inflammatory phenotypes show differential microRNA expression in sputum | Journal of Allergy and Clinical Immunology | 2016 | 168 |
| 20 | MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation | Allergy: European Journal of Allergy and Clinical Immunology | 2015 | 160 |
| 21 | Epithelial cell dysfunction, a major driver of asthma development | Allergy: European Journal of Allergy and Clinical Immunology | 2020 | 151 |
| 22 | Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut | Environmental Microbiology | 2016 | 149 |
| 23 | Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD | Primary Care Respiratory Journal: Journal of the General Practice Airways Group | 2012 | 148 |
| 24 | COPD in the general population: Prevalence, incidence and survival | Respiratory Medicine | 2011 | 145 |
| 25 | Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis | Allergy: European Journal of Allergy and Clinical Immunology | 2011 | 144 |
| 26 | An evolutionary perspective on the necroptotic pathway | Trends in Cell Biology | 2016 | 137 |
| 27 | Minimal important differences for interpreting health-related quality of life scores from the EORTC QLQ-C30 in lung cancer patients participating in randomized controlled trials | Supportive Care in Cancer | 2011 | 133 |
| 28 | Frequent exacerbators – a distinct phenotype of severe asthma | Clinical and Experimental Allergy | 2014 | 132 |
| 29 | Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung | PLoS ONE | 2016 | 132 |
| 30 | Genome-wide association analysis identifies six new loci associated with forced vital capacity | Nature Genetics | 2014 | 131 |
| 31 | Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function | PLoS Genetics | 2012 | 130 |
| 32 | Decreased FOXP3 protein expression in patients with asthma | Allergy: European Journal of Allergy and Clinical Immunology | 2009 | 126 |
| 33 | Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD | Journal of Experimental Medicine | 2017 | 122 |
| 34 | ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle | Clinical and Translational Allergy | 2016 | 121 |
| 35 | Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine | Journal of Pathology | 2020 | 116 |
| 36 | Malignant pleural mesothelioma: The standard of care and challenges for future management | Critical Reviews in Oncology/Hematology | 2011 | 115 |
| 37 | Longitudinal follow-up of IgG anti-nucleocapsid antibodies in SARS-CoV-2 infected patients up to eight months after infection | Journal of Clinical Virology | 2021 | 112 |
| 38 | Lymphoid follicles in (very) severe COPD: beneficial or harmful? | European Respiratory Journal | 2009 | 111 |
| 39 | Targeting Interleukin-4 in Asthma: Lost in Translation? | American Journal of Respiratory Cell and Molecular Biology | 2012 | 111 |
| 40 | Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study | Respiratory Research | 2016 | 110 |
| 41 | Integrated FDG-PET/CT does not make invasive staging of the intrathoracic lymph nodes in non-small cell lung cancer redundant: a prospective study | Thorax | 2007 | 108 |
| 42 | EBUS-TBNA for the Clarification of PET Positive Intra-Thoracic Lymph Nodes—an International Multi-Centre Experience | Journal of Thoracic Oncology | 2009 | 108 |
| 43 | MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease | American Journal of Respiratory and Critical Care Medicine | 2017 | 108 |
| 44 | Chronic Obstructive Pulmonary Disease and the Risk of Stroke. The Rotterdam Study | American Journal of Respiratory and Critical Care Medicine | 2016 | 107 |
| 45 | Endoscopic Ultrasound Reduces Surgical Mediastinal Staging in Lung Cancer | American Journal of Respiratory and Critical Care Medicine | 2008 | 106 |
| 46 | Value of DCE-MRI and FDG-PET/CT in the prediction of response to preoperative chemotherapy with bevacizumab for colorectal liver metastases | British Journal of Cancer | 2012 | 105 |
| 47 | Effects of Pulmonary Rehabilitation in Patients With Restrictive Lung Diseases | Chest | 2010 | 103 |
| 48 | Statins, systemic inflammation and risk of death in COPD: The Rotterdam study | Pulmonary Pharmacology and Therapeutics | 2013 | 102 |
| 49 | Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis | Arthritis Research and Therapy | 2015 | 102 |
| 50 | Long-term Safety and Clinical Benefit of Mepolizumab in Patients With the Most Severe Eosinophilic Asthma: The COSMEX Study | Clinical Therapeutics | 2019 | 102 |
